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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LCT
Full Name:
Lactase-phlorizin hydrolase
Alias:
EC 3.2.1.108; EC 3.2.1.62; LAC; Lactase; Lactase-glycosylceramidase; LPH; LPH1; Phlorizin hydrolase
Type:
Hydrolase; EC 3.2.1.108; Carbohydrate Metabolism - galactose; EC 3.2.1.62
Mass (Da):
218603
Number AA:
1972
UniProt ID:
P09848
International Prot ID:
IPI00017648
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0043169
GO:0017042
GO:0000016
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S321
F
D
I
N
E
F
L
S
C
S
S
S
S
K
K
Site 2
S324
N
E
F
L
S
C
S
S
S
S
K
K
S
M
S
Site 3
S326
F
L
S
C
S
S
S
S
K
K
S
M
S
C
S
Site 4
T539
D
R
V
K
L
W
V
T
F
H
E
P
W
V
M
Site 5
Y551
W
V
M
S
Y
A
G
Y
G
T
G
Q
H
P
P
Site 6
S834
K
S
R
T
P
R
K
S
A
Y
F
F
T
S
I
Site 7
Y836
R
T
P
R
K
S
A
Y
F
F
T
S
I
I
E
Site 8
T839
R
K
S
A
Y
F
F
T
S
I
I
E
K
N
G
Site 9
S840
K
S
A
Y
F
F
T
S
I
I
E
K
N
G
F
Site 10
Y974
R
A
L
K
V
K
A
Y
R
F
S
I
S
W
S
Site 11
Y1068
M
T
F
N
E
P
M
Y
L
A
W
L
G
Y
G
Site 12
Y1303
I
N
E
A
L
K
A
Y
R
L
D
G
I
D
L
Site 13
Y1313
D
G
I
D
L
R
G
Y
V
A
W
S
L
M
D
Site 14
T1725
G
S
F
W
L
K
M
T
P
F
G
F
R
R
I
Site 15
Y1903
C
G
L
A
F
L
S
Y
K
Y
C
K
R
S
K
Site 16
Y1905
L
A
F
L
S
Y
K
Y
C
K
R
S
K
Q
G
Site 17
S1909
S
Y
K
Y
C
K
R
S
K
Q
G
K
T
Q
R
Site 18
T1914
K
R
S
K
Q
G
K
T
Q
R
S
Q
Q
E
L
Site 19
S1917
K
Q
G
K
T
Q
R
S
Q
Q
E
L
S
P
V
Site 20
S1922
Q
R
S
Q
Q
E
L
S
P
V
S
S
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation