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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WEE2
Full Name:
Wee1-like protein kinase 2
Alias:
FLJ16107; WEE1 2; WEE1B; Wee1b; Wee1B kinase; Wee1-like protein kinase 1B; Wee2
Type:
EC 2.7.10.2; Protein kinase, Ser/Thr (non-receptor); Other group; WEE family
Mass (Da):
62925
Number AA:
567
UniProt ID:
P0C1S8
International Prot ID:
IPI00745231
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004715
PhosphoSite+
KinaseNET
Biological Process:
GO:0007067
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
R
Q
K
L
N
F
S
Y
C
E
E
T
E
I
Site 2
S33
G
Q
K
K
V
E
E
S
R
E
A
S
S
Q
T
Site 3
S37
V
E
E
S
R
E
A
S
S
Q
T
P
E
K
G
Site 4
S38
E
E
S
R
E
A
S
S
Q
T
P
E
K
G
E
Site 5
T40
S
R
E
A
S
S
Q
T
P
E
K
G
E
V
Q
Site 6
S49
E
K
G
E
V
Q
D
S
E
A
K
G
T
P
P
Site 7
T54
Q
D
S
E
A
K
G
T
P
P
W
T
P
L
S
Site 8
T58
A
K
G
T
P
P
W
T
P
L
S
N
V
H
E
Site 9
S61
T
P
P
W
T
P
L
S
N
V
H
E
L
D
T
Site 10
S69
N
V
H
E
L
D
T
S
S
E
K
D
K
E
S
Site 11
S70
V
H
E
L
D
T
S
S
E
K
D
K
E
S
P
Site 12
S76
S
S
E
K
D
K
E
S
P
D
Q
I
L
R
T
Site 13
T83
S
P
D
Q
I
L
R
T
P
V
S
H
P
L
K
Site 14
S86
Q
I
L
R
T
P
V
S
H
P
L
K
C
P
E
Site 15
T94
H
P
L
K
C
P
E
T
P
A
Q
P
D
S
R
Site 16
S100
E
T
P
A
Q
P
D
S
R
S
K
L
L
P
S
Site 17
S102
P
A
Q
P
D
S
R
S
K
L
L
P
S
D
S
Site 18
S107
S
R
S
K
L
L
P
S
D
S
P
S
T
P
K
Site 19
S109
S
K
L
L
P
S
D
S
P
S
T
P
K
T
M
Site 20
S111
L
L
P
S
D
S
P
S
T
P
K
T
M
L
S
Site 21
T112
L
P
S
D
S
P
S
T
P
K
T
M
L
S
R
Site 22
T115
D
S
P
S
T
P
K
T
M
L
S
R
L
V
I
Site 23
S118
S
T
P
K
T
M
L
S
R
L
V
I
S
P
T
Site 24
T125
S
R
L
V
I
S
P
T
G
K
L
P
S
R
G
Site 25
S130
S
P
T
G
K
L
P
S
R
G
P
K
H
L
K
Site 26
T139
G
P
K
H
L
K
L
T
P
A
P
L
K
D
E
Site 27
T159
L
V
N
I
N
P
F
T
P
E
S
Y
K
K
L
Site 28
S162
I
N
P
F
T
P
E
S
Y
K
K
L
F
L
Q
Site 29
T202
K
R
C
V
L
R
E
T
N
M
A
S
R
Y
E
Site 30
Y208
E
T
N
M
A
S
R
Y
E
K
E
F
L
E
V
Site 31
T225
I
G
V
G
E
F
G
T
V
Y
K
C
I
K
R
Site 32
Y227
V
G
E
F
G
T
V
Y
K
C
I
K
R
L
D
Site 33
Y238
K
R
L
D
G
C
V
Y
A
I
K
R
S
M
K
Site 34
T246
A
I
K
R
S
M
K
T
F
T
E
L
S
N
E
Site 35
S251
M
K
T
F
T
E
L
S
N
E
N
S
A
L
H
Site 36
S255
T
E
L
S
N
E
N
S
A
L
H
E
V
Y
A
Site 37
Y275
H
H
P
H
V
V
R
Y
Y
S
S
W
A
E
D
Site 38
Y276
H
P
H
V
V
R
Y
Y
S
S
W
A
E
D
D
Site 39
Y291
H
M
I
I
Q
N
E
Y
C
N
G
G
S
L
Q
Site 40
S302
G
S
L
Q
A
A
I
S
E
N
T
K
S
G
N
Site 41
S307
A
I
S
E
N
T
K
S
G
N
H
F
E
E
P
Site 42
S353
F
I
C
H
K
M
Q
S
E
S
S
G
V
I
E
Site 43
S386
G
D
L
G
H
A
T
S
I
N
K
P
K
V
E
Site 44
S397
P
K
V
E
E
G
D
S
R
F
L
A
N
E
I
Site 45
Y409
N
E
I
L
Q
E
D
Y
R
H
L
P
K
A
D
Site 46
T435
A
G
A
E
S
L
P
T
N
G
A
A
W
H
H
Site 47
S456
P
D
V
P
Q
E
L
S
E
S
F
S
S
L
L
Site 48
S458
V
P
Q
E
L
S
E
S
F
S
S
L
L
K
N
Site 49
S460
Q
E
L
S
E
S
F
S
S
L
L
K
N
M
I
Site 50
S461
E
L
S
E
S
F
S
S
L
L
K
N
M
I
Q
Site 51
S476
P
D
A
E
Q
R
P
S
A
A
A
L
A
R
N
Site 52
S489
R
N
T
V
L
R
P
S
L
G
K
T
E
E
L
Site 53
T493
L
R
P
S
L
G
K
T
E
E
L
Q
Q
Q
L
Site 54
T507
L
N
L
E
K
F
K
T
A
T
L
E
R
E
L
Site 55
T509
L
E
K
F
K
T
A
T
L
E
R
E
L
R
E
Site 56
S522
R
E
A
Q
Q
A
Q
S
P
Q
G
Y
T
H
H
Site 57
Y526
Q
A
Q
S
P
Q
G
Y
T
H
H
G
D
T
G
Site 58
T532
G
Y
T
H
H
G
D
T
G
V
S
G
T
H
T
Site 59
S535
H
H
G
D
T
G
V
S
G
T
H
T
G
S
R
Site 60
T537
G
D
T
G
V
S
G
T
H
T
G
S
R
S
T
Site 61
T539
T
G
V
S
G
T
H
T
G
S
R
S
T
K
R
Site 62
S541
V
S
G
T
H
T
G
S
R
S
T
K
R
L
V
Site 63
S543
G
T
H
T
G
S
R
S
T
K
R
L
V
G
G
Site 64
T544
T
H
T
G
S
R
S
T
K
R
L
V
G
G
K
Site 65
S552
K
R
L
V
G
G
K
S
A
R
S
S
S
F
T
Site 66
S555
V
G
G
K
S
A
R
S
S
S
F
T
S
G
E
Site 67
S556
G
G
K
S
A
R
S
S
S
F
T
S
G
E
R
Site 68
S557
G
K
S
A
R
S
S
S
F
T
S
G
E
R
E
Site 69
T559
S
A
R
S
S
S
F
T
S
G
E
R
E
P
L
Site 70
S560
A
R
S
S
S
F
T
S
G
E
R
E
P
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation