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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
G6PD
Full Name:
Glucose-6-phosphate 1-dehydrogenase
Alias:
G6PD1; Glucose-6-phosphate dehydrogenase
Type:
EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase; Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation
Mass (Da):
59257
Number AA:
515
UniProt ID:
P11413
International Prot ID:
IPI00216008
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
GO:0009898
Uniprot
OncoNet
Molecular Function:
GO:0050661
GO:0005536
GO:0004345
PhosphoSite+
KinaseNET
Biological Process:
GO:0034599
GO:0006695
GO:0001816
Phosida
TranscriptoNet
STRING
Kinexus Products
Glucose-6-phosphate 1-dehydrogenase Y401 phosphosite-specific antibody AB-PN515#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN515#Glucose-6-phosphate 1-dehydrogenase (E398-M404, human) pY401 phosphopeptide - Powder PE-04ACV80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ACV80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T76
G
Y
A
R
S
R
L
T
V
A
D
I
R
K
Q
Site 2
S84
V
A
D
I
R
K
Q
S
E
P
F
F
K
A
T
Site 3
T91
S
E
P
F
F
K
A
T
P
E
E
K
L
K
L
Site 4
S106
E
D
F
F
A
R
N
S
Y
V
A
G
Q
Y
D
Site 5
Y107
D
F
F
A
R
N
S
Y
V
A
G
Q
Y
D
D
Site 6
Y112
N
S
Y
V
A
G
Q
Y
D
D
A
A
S
Y
Q
Site 7
S117
G
Q
Y
D
D
A
A
S
Y
Q
R
L
N
S
H
Site 8
Y118
Q
Y
D
D
A
A
S
Y
Q
R
L
N
S
H
M
Site 9
S123
A
S
Y
Q
R
L
N
S
H
M
N
A
L
H
L
Site 10
S132
M
N
A
L
H
L
G
S
Q
A
N
R
L
F
Y
Site 11
S179
P
F
G
R
D
L
Q
S
S
D
R
L
S
N
H
Site 12
S180
F
G
R
D
L
Q
S
S
D
R
L
S
N
H
I
Site 13
S184
L
Q
S
S
D
R
L
S
N
H
I
S
S
L
F
Site 14
S188
D
R
L
S
N
H
I
S
S
L
F
R
E
D
Q
Site 15
S189
R
L
S
N
H
I
S
S
L
F
R
E
D
Q
I
Site 16
Y197
L
F
R
E
D
Q
I
Y
R
I
D
H
Y
L
G
Site 17
Y202
Q
I
Y
R
I
D
H
Y
L
G
K
E
M
V
Q
Site 18
T243
T
F
K
E
P
F
G
T
E
G
R
G
G
Y
F
Site 19
Y249
G
T
E
G
R
G
G
Y
F
D
E
F
G
I
I
Site 20
S278
V
A
M
E
K
P
A
S
T
N
S
D
D
V
R
Site 21
S281
E
K
P
A
S
T
N
S
D
D
V
R
D
E
K
Site 22
S296
V
K
V
L
K
C
I
S
E
V
Q
A
N
N
V
Site 23
Y308
N
N
V
V
L
G
Q
Y
V
G
N
P
D
G
E
Site 24
T319
P
D
G
E
G
E
A
T
K
G
Y
L
D
D
P
Site 25
Y322
E
G
E
A
T
K
G
Y
L
D
D
P
T
V
P
Site 26
T327
K
G
Y
L
D
D
P
T
V
P
R
G
S
T
T
Site 27
S332
D
P
T
V
P
R
G
S
T
T
A
T
F
A
A
Site 28
Y401
V
Q
P
N
E
A
V
Y
T
K
M
M
T
K
K
Glucose-6-phosphate 1-dehydrogenase Y401 phosphosite-specific antibody AB-PN515#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN515#Glucose-6-phosphate 1-dehydrogenase (E398-M404, human) pY401 phosphopeptide - Powder PE-04ACV80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ACV80
Site 29
T402
Q
P
N
E
A
V
Y
T
K
M
M
T
K
K
P
Site 30
S418
M
F
F
N
P
E
E
S
E
L
D
L
T
Y
G
Site 31
T423
E
E
S
E
L
D
L
T
Y
G
N
R
Y
K
N
Site 32
Y424
E
S
E
L
D
L
T
Y
G
N
R
Y
K
N
V
Site 33
Y428
D
L
T
Y
G
N
R
Y
K
N
V
K
L
P
D
Site 34
S455
S
Q
M
H
F
V
R
S
D
E
L
R
E
A
W
Site 35
T466
R
E
A
W
R
I
F
T
P
L
L
H
Q
I
E
Site 36
Y482
E
K
P
K
P
I
P
Y
I
Y
G
S
R
G
P
Site 37
Y484
P
K
P
I
P
Y
I
Y
G
S
R
G
P
T
E
Site 38
S486
P
I
P
Y
I
Y
G
S
R
G
P
T
E
A
D
Site 39
T490
I
Y
G
S
R
G
P
T
E
A
D
E
L
M
K
Site 40
Y503
M
K
R
V
G
F
Q
Y
E
G
T
Y
K
W
V
Site 41
T506
V
G
F
Q
Y
E
G
T
Y
K
W
V
N
P
H
Site 42
Y507
G
F
Q
Y
E
G
T
Y
K
W
V
N
P
H
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation