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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CKB
Full Name:
Creatine kinase B-type
Alias:
CKBB; Creatine kinase, B chain; Creatine kinase, brain; KCRB
Type:
Amino Acid Metabolism - arginine and proline; Kinase (non-protein); EC 2.7.3.2
Mass (Da):
42644
Number AA:
381
UniProt ID:
P12277
International Prot ID:
IPI00022977
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004111
PhosphoSite+
KinaseNET
Biological Process:
GO:0006600
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
P
F
S
N
S
H
N
A
L
K
Site 2
T35
N
H
M
A
K
V
L
T
P
E
L
Y
A
E
L
Site 3
Y39
K
V
L
T
P
E
L
Y
A
E
L
R
A
K
S
Site 4
S46
Y
A
E
L
R
A
K
S
T
P
S
G
F
T
L
Site 5
T47
A
E
L
R
A
K
S
T
P
S
G
F
T
L
D
Site 6
S81
C
V
A
G
D
E
E
S
Y
E
V
F
K
D
L
Site 7
Y82
V
A
G
D
E
E
S
Y
E
V
F
K
D
L
F
Site 8
Y100
I
E
D
R
H
G
G
Y
K
P
S
D
E
H
K
Site 9
S103
R
H
G
G
Y
K
P
S
D
E
H
K
T
D
L
Site 10
T108
K
P
S
D
E
H
K
T
D
L
N
P
D
N
L
Site 11
Y125
G
D
D
L
D
P
N
Y
V
L
S
S
R
V
R
Site 12
S128
L
D
P
N
Y
V
L
S
S
R
V
R
T
G
R
Site 13
S129
D
P
N
Y
V
L
S
S
R
V
R
T
G
R
S
Site 14
T133
V
L
S
S
R
V
R
T
G
R
S
I
R
G
F
Site 15
S136
S
R
V
R
T
G
R
S
I
R
G
F
C
L
P
Site 16
S163
K
L
A
V
E
A
L
S
S
L
D
G
D
L
A
Site 17
S164
L
A
V
E
A
L
S
S
L
D
G
D
L
A
G
Site 18
Y173
D
G
D
L
A
G
R
Y
Y
A
L
K
S
M
T
Site 19
Y174
G
D
L
A
G
R
Y
Y
A
L
K
S
M
T
E
Site 20
S178
G
R
Y
Y
A
L
K
S
M
T
E
A
E
Q
Q
Site 21
S199
F
L
F
D
K
P
V
S
P
L
L
L
A
S
G
Site 22
S239
E
D
H
L
R
V
I
S
M
Q
K
G
G
N
M
Site 23
T258
T
R
F
C
T
G
L
T
Q
I
E
T
L
F
K
Site 24
T262
T
G
L
T
Q
I
E
T
L
F
K
S
K
D
Y
Site 25
Y269
T
L
F
K
S
K
D
Y
E
F
M
W
N
P
H
Site 26
Y279
M
W
N
P
H
L
G
Y
I
L
T
C
P
S
N
Site 27
T282
P
H
L
G
Y
I
L
T
C
P
S
N
L
G
T
Site 28
S285
G
Y
I
L
T
C
P
S
N
L
G
T
G
L
R
Site 29
T289
T
C
P
S
N
L
G
T
G
L
R
A
G
V
H
Site 30
S309
L
G
K
H
E
K
F
S
E
V
L
K
R
L
R
Site 31
T322
L
R
L
Q
K
R
G
T
G
G
V
D
T
A
A
Site 32
T327
R
G
T
G
G
V
D
T
A
A
V
G
G
V
F
Site 33
S345
N
A
D
R
L
G
F
S
E
V
E
L
V
Q
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation