KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
BCKDHA
Full Name:
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
Alias:
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; BCKDE1A; EC 1.2.4.4; ODBA
Type:
EC 1.2.4.4; Lyase; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Oxidoreductase
Mass (Da):
50471
Number AA:
445
UniProt ID:
P12694
International Prot ID:
IPI00025100
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005947
Uniprot
OncoNet
Molecular Function:
GO:0003863
GO:0003826
GO:0016831
PhosphoSite+
KinaseNET
Biological Process:
GO:0009083
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
G
A
R
G
L
A
R
S
H
P
P
R
Q
Q
Q
Site 2
S47
R
Q
Q
Q
Q
F
S
S
L
D
D
K
P
Q
F
Site 3
S92
Q
G
Q
I
I
N
P
S
E
D
P
H
L
P
K
Site 4
Y106
K
E
K
V
L
K
L
Y
K
S
M
T
L
L
N
Site 5
T110
L
K
L
Y
K
S
M
T
L
L
N
T
M
D
R
Site 6
T114
K
S
M
T
L
L
N
T
M
D
R
I
L
Y
E
Site 7
Y120
N
T
M
D
R
I
L
Y
E
S
Q
R
Q
G
R
Site 8
S122
M
D
R
I
L
Y
E
S
Q
R
Q
G
R
I
S
Site 9
S129
S
Q
R
Q
G
R
I
S
F
Y
M
T
N
Y
G
Site 10
Y131
R
Q
G
R
I
S
F
Y
M
T
N
Y
G
E
E
Site 11
T133
G
R
I
S
F
Y
M
T
N
Y
G
E
E
G
T
Site 12
Y135
I
S
F
Y
M
T
N
Y
G
E
E
G
T
H
V
Site 13
Y195
G
R
Q
M
P
V
H
Y
G
C
K
E
R
H
F
Site 14
S242
Y
F
G
E
G
A
A
S
E
G
D
A
H
A
G
Site 15
Y269
F
F
C
R
N
N
G
Y
A
I
S
T
P
T
S
Site 16
S272
R
N
N
G
Y
A
I
S
T
P
T
S
E
Q
Y
Site 17
T273
N
N
G
Y
A
I
S
T
P
T
S
E
Q
Y
R
Site 18
S276
Y
A
I
S
T
P
T
S
E
Q
Y
R
G
D
G
Site 19
S295
G
P
G
Y
G
I
M
S
I
R
V
D
G
N
D
Site 20
Y307
G
N
D
V
F
A
V
Y
N
A
T
K
E
A
R
Site 21
Y331
F
L
I
E
A
M
T
Y
R
I
G
H
H
S
T
Site 22
S337
T
Y
R
I
G
H
H
S
T
S
D
D
S
S
A
Site 23
T338
Y
R
I
G
H
H
S
T
S
D
D
S
S
A
Y
Site 24
S339
R
I
G
H
H
S
T
S
D
D
S
S
A
Y
R
Site 25
S342
H
H
S
T
S
D
D
S
S
A
Y
R
S
V
D
Site 26
S343
H
S
T
S
D
D
S
S
A
Y
R
S
V
D
E
Site 27
Y345
T
S
D
D
S
S
A
Y
R
S
V
D
E
V
N
Site 28
S347
D
D
S
S
A
Y
R
S
V
D
E
V
N
Y
W
Site 29
Y353
R
S
V
D
E
V
N
Y
W
D
K
Q
D
H
P
Site 30
S362
D
K
Q
D
H
P
I
S
R
L
R
H
Y
L
L
Site 31
Y367
P
I
S
R
L
R
H
Y
L
L
S
Q
G
W
W
Site 32
S370
R
L
R
H
Y
L
L
S
Q
G
W
W
D
E
E
Site 33
S386
E
K
A
W
R
K
Q
S
R
R
K
V
M
E
A
Site 34
S410
P
N
P
N
L
L
F
S
D
V
Y
Q
E
M
P
Site 35
Y413
N
L
L
F
S
D
V
Y
Q
E
M
P
A
Q
L
Site 36
S426
Q
L
R
K
Q
Q
E
S
L
A
R
H
L
Q
T
Site 37
Y434
L
A
R
H
L
Q
T
Y
G
E
H
Y
P
L
D
Site 38
Y438
L
Q
T
Y
G
E
H
Y
P
L
D
H
F
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation