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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GFAP
Full Name:
Glial fibrillary acidic protein
Alias:
FLJ45472; glial fibrillary acidic protein; Glial fibrillary acidic protein, astrocyte; intermediate filament protein
Type:
Cytoskeletal protein
Mass (Da):
49880
Number AA:
432
UniProt ID:
P14136
International Prot ID:
IPI00025363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Glial fibrillary acidic protein pan-specific antibody AB-NN260-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN260-1#Glial fibrillary acidic protein pan-specific antibody AB-NN260-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN260-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
E
R
R
R
I
T
S
A
A
R
R
S
Y
Site 2
S8
M
E
R
R
R
I
T
S
A
A
R
R
S
Y
V
Site 3
S13
I
T
S
A
A
R
R
S
Y
V
S
S
G
E
M
Site 4
Y14
T
S
A
A
R
R
S
Y
V
S
S
G
E
M
M
Site 5
S16
A
A
R
R
S
Y
V
S
S
G
E
M
M
V
G
Site 6
S17
A
R
R
S
Y
V
S
S
G
E
M
M
V
G
G
Site 7
T35
G
R
R
L
G
P
G
T
R
L
S
L
A
R
M
Site 8
S38
L
G
P
G
T
R
L
S
L
A
R
M
P
P
P
Site 9
T48
R
M
P
P
P
L
P
T
R
V
D
F
S
L
A
Site 10
S68
G
F
K
E
T
R
A
S
E
R
A
E
M
M
E
Site 11
S82
E
L
N
D
R
F
A
S
Y
I
E
K
V
R
F
Site 12
Y83
L
N
D
R
F
A
S
Y
I
E
K
V
R
F
L
Site 13
T110
Q
L
R
A
K
E
P
T
K
L
A
D
V
Y
Q
Site 14
Y116
P
T
K
L
A
D
V
Y
Q
A
E
L
R
E
L
Site 15
T131
R
L
R
L
D
Q
L
T
A
N
S
A
R
L
E
Site 16
T150
N
L
A
Q
D
L
A
T
V
R
Q
K
L
Q
D
Site 17
Y172
A
E
N
N
L
A
A
Y
R
Q
E
A
D
E
A
Site 18
T180
R
Q
E
A
D
E
A
T
L
A
R
L
D
L
E
Site 19
S192
D
L
E
R
K
I
E
S
L
E
E
E
I
R
F
Site 20
T232
D
V
A
K
P
D
L
T
A
A
L
K
E
I
R
Site 21
Y242
L
K
E
I
R
T
Q
Y
E
A
M
A
S
S
N
Site 22
Y257
M
H
E
A
E
E
W
Y
R
S
K
F
A
D
L
Site 23
S259
E
A
E
E
W
Y
R
S
K
F
A
D
L
T
D
Site 24
T265
R
S
K
F
A
D
L
T
D
A
A
A
R
N
A
Site 25
Y285
A
K
H
E
A
N
D
Y
R
R
Q
L
Q
S
L
Site 26
S291
D
Y
R
R
Q
L
Q
S
L
T
C
D
L
E
S
Site 27
T293
R
R
Q
L
Q
S
L
T
C
D
L
E
S
L
R
Site 28
S298
S
L
T
C
D
L
E
S
L
R
G
T
N
E
S
Site 29
T302
D
L
E
S
L
R
G
T
N
E
S
L
E
R
Q
Site 30
S305
S
L
R
G
T
N
E
S
L
E
R
Q
M
R
E
Site 31
S323
R
H
V
R
E
A
A
S
Y
Q
E
A
L
A
R
Site 32
Y324
H
V
R
E
A
A
S
Y
Q
E
A
L
A
R
L
Site 33
S337
R
L
E
E
E
G
Q
S
L
K
D
E
M
A
R
Site 34
Y349
M
A
R
H
L
Q
E
Y
Q
D
L
L
N
V
K
Site 35
Y366
L
D
I
E
I
A
T
Y
R
K
L
L
E
G
E
Site 36
T378
E
G
E
E
N
R
I
T
I
P
V
Q
T
F
S
Site 37
T383
R
I
T
I
P
V
Q
T
F
S
N
L
Q
I
R
Site 38
S385
T
I
P
V
Q
T
F
S
N
L
Q
I
R
E
T
Site 39
T392
S
N
L
Q
I
R
E
T
S
L
D
T
K
S
V
Site 40
S393
N
L
Q
I
R
E
T
S
L
D
T
K
S
V
S
Site 41
T396
I
R
E
T
S
L
D
T
K
S
V
S
E
G
H
Site 42
S398
E
T
S
L
D
T
K
S
V
S
E
G
H
L
K
Site 43
S400
S
L
D
T
K
S
V
S
E
G
H
L
K
R
N
Site 44
T412
K
R
N
I
V
V
K
T
V
E
M
R
D
G
E
Site 45
S424
D
G
E
V
I
K
E
S
K
Q
E
H
K
D
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation