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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cyclin B1
Full Name:
G2/mitotic-specific cyclin-B1
Alias:
CCN2; CCN-2; CCNB; CCNB1-RS1; CYCB; CYCB1
Type:
Protein-serine kinase regulatory subunit, activator, cyclin
Mass (Da):
48337
Number AA:
433
UniProt ID:
P14635
International Prot ID:
IPI00745793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000086
GO:0031145
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
L
R
V
T
R
N
S
K
I
N
A
E
N
K
Site 2
T29
A
G
A
K
R
V
P
T
A
P
A
A
T
S
K
Site 3
S35
P
T
A
P
A
A
T
S
K
P
G
L
R
P
R
Site 4
T43
K
P
G
L
R
P
R
T
A
L
G
D
I
G
N
Site 5
S69
M
K
K
E
A
K
P
S
A
T
G
K
V
I
D
Site 6
S116
P
V
K
E
E
K
L
S
P
E
P
I
L
V
D
Site 7
T124
P
E
P
I
L
V
D
T
A
S
P
S
P
M
E
Site 8
S126
P
I
L
V
D
T
A
S
P
S
P
M
E
T
S
Site 9
S128
L
V
D
T
A
S
P
S
P
M
E
T
S
G
C
Site 10
T132
A
S
P
S
P
M
E
T
S
G
C
A
P
A
E
Site 11
S133
S
P
S
P
M
E
T
S
G
C
A
P
A
E
E
Site 12
S147
E
D
L
C
Q
A
F
S
D
V
I
L
A
V
N
Site 13
Y170
D
P
N
L
C
S
E
Y
V
K
D
I
Y
A
Y
Site 14
Y175
S
E
Y
V
K
D
I
Y
A
Y
L
R
Q
L
E
Site 15
Y177
Y
V
K
D
I
Y
A
Y
L
R
Q
L
E
E
E
Site 16
Y191
E
Q
A
V
R
P
K
Y
L
L
G
R
E
V
T
Site 17
Y258
A
M
F
I
A
S
K
Y
E
E
M
Y
P
P
E
Site 18
Y262
A
S
K
Y
E
E
M
Y
P
P
E
I
G
D
F
Site 19
T276
F
A
F
V
T
D
N
T
Y
T
K
H
Q
I
R
Site 20
Y277
A
F
V
T
D
N
T
Y
T
K
H
Q
I
R
Q
Site 21
S310
L
H
F
L
R
R
A
S
K
I
G
E
V
D
V
Site 22
T321
E
V
D
V
E
Q
H
T
L
A
K
Y
L
M
E
Site 23
Y325
E
Q
H
T
L
A
K
Y
L
M
E
L
T
M
L
Site 24
T362
I
L
D
N
G
E
W
T
P
T
L
Q
H
Y
L
Site 25
T364
D
N
G
E
W
T
P
T
L
Q
H
Y
L
S
Y
Site 26
Y368
W
T
P
T
L
Q
H
Y
L
S
Y
T
E
E
S
Site 27
S370
P
T
L
Q
H
Y
L
S
Y
T
E
E
S
L
L
Site 28
Y371
T
L
Q
H
Y
L
S
Y
T
E
E
S
L
L
P
Site 29
T372
L
Q
H
Y
L
S
Y
T
E
E
S
L
L
P
V
Site 30
T399
Q
G
L
T
K
H
M
T
V
K
N
K
Y
A
T
Site 31
Y404
H
M
T
V
K
N
K
Y
A
T
S
K
H
A
K
Site 32
S407
V
K
N
K
Y
A
T
S
K
H
A
K
I
S
T
Site 33
S413
T
S
K
H
A
K
I
S
T
L
P
Q
L
N
S
Site 34
T414
S
K
H
A
K
I
S
T
L
P
Q
L
N
S
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation