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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VAV1
Full Name:
Proto-oncogene vav
Alias:
VAV; vav 1 guanine nucleotide exchange factor; Vav proto-oncogene
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
98314
Number AA:
845
UniProt ID:
P15498
International Prot ID:
IPI00011696
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Vav 1 guanine nucleotide exchange factor Y826 phosphosite-specific antibody AB-PN543#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN543#Vav 1 guanine nucleotide exchange factor (G823-V829, human) pY826 phosphopeptide - Powder PE-04AEO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEO99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
L
P
P
S
H
R
V
T
W
D
G
A
Q
V
C
Site 2
S67
V
N
L
R
P
Q
M
S
Q
F
L
C
L
K
N
Site 3
S91
E
K
F
G
L
K
R
S
E
L
F
E
A
F
D
Site 4
Y110
Q
D
F
G
K
V
I
Y
T
L
S
A
L
S
W
Site 5
T118
T
L
S
A
L
S
W
T
P
I
A
Q
N
R
G
Site 6
T131
R
G
I
M
P
F
P
T
E
E
E
S
V
G
D
Site 7
S135
P
F
P
T
E
E
E
S
V
G
D
E
D
I
Y
Site 8
Y142
S
V
G
D
E
D
I
Y
S
G
L
S
D
Q
I
Site 9
S143
V
G
D
E
D
I
Y
S
G
L
S
D
Q
I
D
Site 10
T152
L
S
D
Q
I
D
D
T
V
E
E
D
E
D
L
Site 11
Y160
V
E
E
D
E
D
L
Y
D
C
V
E
N
E
E
Site 12
Y174
E
A
E
G
D
E
I
Y
E
D
L
M
R
S
E
Site 13
S180
I
Y
E
D
L
M
R
S
E
P
V
S
M
P
P
Site 14
S184
L
M
R
S
E
P
V
S
M
P
P
K
M
T
E
Site 15
Y192
M
P
P
K
M
T
E
Y
D
K
R
C
C
C
L
Site 16
T205
C
L
R
E
I
Q
Q
T
E
E
K
Y
T
D
T
Site 17
Y209
I
Q
Q
T
E
E
K
Y
T
D
T
L
G
S
I
Site 18
T210
Q
Q
T
E
E
K
Y
T
D
T
L
G
S
I
Q
Site 19
T212
T
E
E
K
Y
T
D
T
L
G
S
I
Q
Q
H
Site 20
T248
E
D
L
L
R
V
H
T
H
F
L
K
E
M
K
Site 21
T260
E
M
K
E
A
L
G
T
P
G
A
A
N
L
Y
Site 22
Y267
T
P
G
A
A
N
L
Y
Q
V
F
I
K
Y
K
Site 23
Y280
Y
K
E
R
F
L
V
Y
G
R
Y
C
S
Q
V
Site 24
Y283
R
F
L
V
Y
G
R
Y
C
S
Q
V
E
S
A
Site 25
S285
L
V
Y
G
R
Y
C
S
Q
V
E
S
A
S
K
Site 26
S289
R
Y
C
S
Q
V
E
S
A
S
K
H
L
D
R
Site 27
S312
Q
M
K
L
E
E
C
S
Q
R
A
N
N
G
R
Site 28
T321
R
A
N
N
G
R
F
T
L
R
D
L
L
M
V
Site 29
Y336
P
M
Q
R
V
L
K
Y
H
L
L
L
Q
E
L
Site 30
T379
E
V
K
R
D
N
E
T
L
R
Q
I
T
N
F
Site 31
T384
N
E
T
L
R
Q
I
T
N
F
Q
L
S
I
E
Site 32
S389
Q
I
T
N
F
Q
L
S
I
E
N
L
D
Q
S
Site 33
S396
S
I
E
N
L
D
Q
S
L
A
H
Y
G
R
P
Site 34
Y400
L
D
Q
S
L
A
H
Y
G
R
P
K
I
D
G
Site 35
T412
I
D
G
E
L
K
I
T
S
V
E
R
R
S
K
Site 36
S413
D
G
E
L
K
I
T
S
V
E
R
R
S
K
M
Site 37
S418
I
T
S
V
E
R
R
S
K
M
D
R
Y
A
F
Site 38
Y423
R
R
S
K
M
D
R
Y
A
F
L
L
D
K
A
Site 39
S440
I
C
K
R
R
G
D
S
Y
D
L
K
D
F
V
Site 40
Y441
C
K
R
R
G
D
S
Y
D
L
K
D
F
V
N
Site 41
S451
K
D
F
V
N
L
H
S
F
Q
V
R
D
D
S
Site 42
S458
S
F
Q
V
R
D
D
S
S
G
D
R
D
N
K
Site 43
S459
F
Q
V
R
D
D
S
S
G
D
R
D
N
K
K
Site 44
Y507
E
M
A
I
S
N
I
Y
P
E
N
A
T
A
N
Site 45
Y541
M
L
L
R
G
T
F
Y
Q
G
Y
R
C
H
R
Site 46
Y544
R
G
T
F
Y
Q
G
Y
R
C
H
R
C
R
A
Site 47
T574
H
G
Q
D
F
P
G
T
M
K
K
D
K
L
H
Site 48
Y603
K
M
E
V
F
Q
E
Y
Y
G
L
P
P
P
P
Site 49
Y604
M
E
V
F
Q
E
Y
Y
G
L
P
P
P
P
G
Site 50
T628
P
G
D
I
V
E
L
T
K
A
E
A
E
Q
N
Site 51
Y658
P
C
N
R
V
K
P
Y
V
H
G
P
P
Q
D
Site 52
Y672
D
L
S
V
H
L
W
Y
A
G
P
M
E
R
A
Site 53
S683
M
E
R
A
G
A
E
S
I
L
A
N
R
S
D
Site 54
S689
E
S
I
L
A
N
R
S
D
G
T
F
L
V
R
Site 55
T692
L
A
N
R
S
D
G
T
F
L
V
R
Q
R
V
Site 56
T730
A
E
G
L
Y
R
I
T
E
K
K
A
F
R
G
Site 57
T739
K
K
A
F
R
G
L
T
E
L
V
E
F
Y
Q
Site 58
Y745
L
T
E
L
V
E
F
Y
Q
Q
N
S
L
K
D
Site 59
S756
S
L
K
D
C
F
K
S
L
D
T
T
L
Q
F
Site 60
T759
D
C
F
K
S
L
D
T
T
L
Q
F
P
F
K
Site 61
T760
C
F
K
S
L
D
T
T
L
Q
F
P
F
K
E
Site 62
S774
E
P
E
K
R
T
I
S
R
P
A
V
G
S
T
Site 63
S780
I
S
R
P
A
V
G
S
T
K
Y
F
G
T
A
Site 64
Y783
P
A
V
G
S
T
K
Y
F
G
T
A
K
A
R
Site 65
Y791
F
G
T
A
K
A
R
Y
D
F
C
A
R
D
R
Site 66
S799
D
F
C
A
R
D
R
S
E
L
S
L
K
E
G
Site 67
Y826
G
W
W
R
G
E
I
Y
G
R
V
G
W
F
P
Vav 1 guanine nucleotide exchange factor Y826 phosphosite-specific antibody AB-PN543#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN543#Vav 1 guanine nucleotide exchange factor (G823-V829, human) pY826 phosphopeptide - Powder PE-04AEO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEO99
Site 68
Y836
V
G
W
F
P
A
N
Y
V
E
E
D
Y
S
E
Site 69
Y841
A
N
Y
V
E
E
D
Y
S
E
Y
C
_
_
_
Site 70
S842
N
Y
V
E
E
D
Y
S
E
Y
C
_
_
_
_
Site 71
Y844
V
E
E
D
Y
S
E
Y
C
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation