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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANP-alpha R
Full Name:
Atrial natriuretic peptide receptor 1
Alias:
ANP-A; ANPRA; EC 4.6.1.2; GC-A; Guanylate cyclase; NPR1; NPRA
Type:
Guanylyl cyclase; Protein kinaseProtein-serine kinase (receptor, RGC group, RGC family
Mass (Da):
118919
Number AA:
1061
UniProt ID:
P16066
International Prot ID:
IPI00027200
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005525
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0006182
GO:0007166
GO:0030146
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
P
R
R
P
A
G
S
R
L
R
L
L
L
L
Site 2
S505
Q
L
E
K
E
L
A
S
E
L
W
R
V
R
W
Site 3
S519
W
E
D
V
E
P
S
S
L
E
R
H
L
R
S
Site 4
S526
S
L
E
R
H
L
R
S
A
G
S
R
L
T
L
Site 5
S529
R
H
L
R
S
A
G
S
R
L
T
L
S
G
R
Site 6
T532
R
S
A
G
S
R
L
T
L
S
G
R
G
S
N
Site 7
S534
A
G
S
R
L
T
L
S
G
R
G
S
N
Y
G
Site 8
S538
L
T
L
S
G
R
G
S
N
Y
G
S
L
L
T
Site 9
Y540
L
S
G
R
G
S
N
Y
G
S
L
L
T
T
E
Site 10
S542
G
R
G
S
N
Y
G
S
L
L
T
T
E
G
Q
Site 11
T545
S
N
Y
G
S
L
L
T
T
E
G
Q
F
Q
V
Site 12
T546
N
Y
G
S
L
L
T
T
E
G
Q
F
Q
V
F
Site 13
T612
P
P
N
I
C
I
L
T
E
Y
C
P
R
G
S
Site 14
S619
T
E
Y
C
P
R
G
S
L
Q
D
I
L
E
N
Site 15
S657
L
H
N
G
A
I
C
S
H
G
N
L
K
S
S
Site 16
S663
C
S
H
G
N
L
K
S
S
N
C
V
V
D
G
Site 17
S664
S
H
G
N
L
K
S
S
N
C
V
V
D
G
R
Site 18
Y679
F
V
L
K
I
T
D
Y
G
L
E
S
F
R
D
Site 19
S683
I
T
D
Y
G
L
E
S
F
R
D
L
D
P
E
Site 20
T694
L
D
P
E
Q
G
H
T
V
Y
A
K
K
L
W
Site 21
S711
P
E
L
L
R
M
A
S
P
P
V
R
G
S
Q
Site 22
S717
A
S
P
P
V
R
G
S
Q
A
G
D
V
Y
S
Site 23
S747
H
V
E
G
L
D
L
S
P
K
E
I
I
E
R
Site 24
T756
K
E
I
I
E
R
V
T
R
G
E
Q
P
P
F
Site 25
S766
E
Q
P
P
F
R
P
S
L
A
L
Q
S
H
L
Site 26
S771
R
P
S
L
A
L
Q
S
H
L
E
E
L
G
L
Site 27
T800
P
F
Q
Q
I
R
L
T
L
R
K
F
N
R
E
Site 28
S809
R
K
F
N
R
E
N
S
S
N
I
L
D
N
L
Site 29
S818
N
I
L
D
N
L
L
S
R
M
E
Q
Y
A
N
Site 30
T835
E
E
L
V
E
E
R
T
Q
A
Y
L
E
E
K
Site 31
S856
L
Y
Q
I
L
P
H
S
V
A
E
Q
L
K
R
Site 32
T866
E
Q
L
K
R
G
E
T
V
Q
A
E
A
F
D
Site 33
Y927
V
E
T
I
G
D
A
Y
M
V
V
S
G
L
P
Site 34
S958
A
L
L
D
A
V
R
S
F
R
I
R
H
R
P
Site 35
S1003
G
D
T
V
N
T
A
S
R
M
E
S
N
G
E
Site 36
S1007
N
T
A
S
R
M
E
S
N
G
E
A
L
K
I
Site 37
T1048
K
G
K
G
K
V
R
T
Y
W
L
L
G
E
R
Site 38
Y1049
G
K
G
K
V
R
T
Y
W
L
L
G
E
R
G
Site 39
S1057
W
L
L
G
E
R
G
S
S
T
R
G
_
_
_
Site 40
S1058
L
L
G
E
R
G
S
S
T
R
G
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation