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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CTPS
Full Name:
CTP synthase 1
Alias:
CTP synthase; CTP synthetase; PYRG; PYRG1; UTP--ammonia ligase
Type:
Nucleotide Metabolism - pyrimidine; EC 6.3.4.2; Ligase
Mass (Da):
66690
Number AA:
591
UniProt ID:
P17812
International Prot ID:
IPI00290142
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0044424
GO:0044444
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003883
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006241
GO:0006541
GO:0042493
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
Site 2
Y42
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
Site 3
T49
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
Site 4
S51
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
Site 5
Y53
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
Site 6
Y74
V
D
L
D
L
G
N
Y
E
R
F
L
D
I
R
Site 7
T83
R
F
L
D
I
R
L
T
K
D
N
N
L
T
T
Site 8
Y94
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
Site 9
Y96
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
Site 10
Y106
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
Site 11
T110
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
Site 12
S181
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
Site 13
S187
V
S
L
V
P
Q
P
S
S
T
G
E
Q
K
T
Site 14
S188
S
L
V
P
Q
P
S
S
T
G
E
Q
K
T
K
Site 15
T194
S
S
T
G
E
Q
K
T
K
P
T
Q
N
S
V
Site 16
S200
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
Site 17
T224
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
Site 18
S225
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
Site 19
Y265
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
Site 20
Y292
W
K
E
M
A
D
R
Y
D
R
L
L
E
T
C
Site 21
Y307
S
I
A
L
V
G
K
Y
T
K
F
S
D
S
Y
Site 22
S313
K
Y
T
K
F
S
D
S
Y
A
S
V
I
K
A
Site 23
Y314
Y
T
K
F
S
D
S
Y
A
S
V
I
K
A
L
Site 24
S316
K
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
Site 25
S339
L
E
I
K
Y
I
D
S
A
D
L
E
P
I
T
Site 26
T346
S
A
D
L
E
P
I
T
S
Q
E
E
P
V
R
Site 27
S347
A
D
L
E
P
I
T
S
Q
E
E
P
V
R
Y
Site 28
Y354
S
Q
E
E
P
V
R
Y
H
E
A
W
Q
K
L
Site 29
T378
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
Site 30
S421
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
Site 31
T427
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
Site 32
T428
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
Site 33
T455
M
R
L
G
K
R
R
T
L
F
Q
T
K
N
S
Site 34
T459
K
R
R
T
L
F
Q
T
K
N
S
V
M
R
K
Site 35
S462
T
L
F
Q
T
K
N
S
V
M
R
K
L
Y
G
Site 36
Y468
N
S
V
M
R
K
L
Y
G
D
A
D
Y
L
E
Site 37
Y473
K
L
Y
G
D
A
D
Y
L
E
E
R
H
R
H
Site 38
Y525
P
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
Site 39
S531
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
Site 40
S537
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
Site 41
Y540
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
Site 42
S552
L
A
S
V
G
R
L
S
H
Y
L
Q
K
G
C
Site 43
Y554
S
V
G
R
L
S
H
Y
L
Q
K
G
C
R
L
Site 44
S562
L
Q
K
G
C
R
L
S
P
R
D
T
Y
S
D
Site 45
T566
C
R
L
S
P
R
D
T
Y
S
D
R
S
G
S
Site 46
Y567
R
L
S
P
R
D
T
Y
S
D
R
S
G
S
S
Site 47
S568
L
S
P
R
D
T
Y
S
D
R
S
G
S
S
S
Site 48
S571
R
D
T
Y
S
D
R
S
G
S
S
S
P
D
S
Site 49
S573
T
Y
S
D
R
S
G
S
S
S
P
D
S
E
I
Site 50
S574
Y
S
D
R
S
G
S
S
S
P
D
S
E
I
T
Site 51
S575
S
D
R
S
G
S
S
S
P
D
S
E
I
T
E
Site 52
S578
S
G
S
S
S
P
D
S
E
I
T
E
L
K
F
Site 53
T581
S
S
P
D
S
E
I
T
E
L
K
F
P
S
I
Site 54
S587
I
T
E
L
K
F
P
S
I
N
H
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation