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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XRCC1
Full Name:
DNA repair protein XRCC1
Alias:
DNA-repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1; XRC1
Type:
DNA repair protein
Mass (Da):
69526
Number AA:
633
UniProt ID:
P18887
International Prot ID:
IPI00002564
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003684
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
I
R
L
R
H
V
V
S
C
S
S
Q
D
S
T
Site 2
S13
L
R
H
V
V
S
C
S
S
Q
D
S
T
H
C
Site 3
S14
R
H
V
V
S
C
S
S
Q
D
S
T
H
C
A
Site 4
S17
V
S
C
S
S
Q
D
S
T
H
C
A
E
N
L
Site 5
T18
S
C
S
S
Q
D
S
T
H
C
A
E
N
L
L
Site 6
T29
E
N
L
L
K
A
D
T
Y
R
K
W
R
A
A
Site 7
Y30
N
L
L
K
A
D
T
Y
R
K
W
R
A
A
K
Site 8
S44
K
A
G
E
K
T
I
S
V
V
L
Q
L
E
K
Site 9
S57
E
K
E
E
Q
I
H
S
V
D
I
G
N
D
G
Site 10
Y84
G
G
A
G
E
Q
D
Y
E
V
L
L
V
T
S
Site 11
S95
L
V
T
S
S
F
M
S
P
S
E
S
R
S
G
Site 12
S97
T
S
S
F
M
S
P
S
E
S
R
S
G
S
N
Site 13
S99
S
F
M
S
P
S
E
S
R
S
G
S
N
P
N
Site 14
S101
M
S
P
S
E
S
R
S
G
S
N
P
N
R
V
Site 15
S103
P
S
E
S
R
S
G
S
N
P
N
R
V
R
M
Site 16
S133
D
R
V
K
I
V
C
S
Q
P
Y
S
K
D
S
Site 17
Y136
K
I
V
C
S
Q
P
Y
S
K
D
S
P
F
G
Site 18
S137
I
V
C
S
Q
P
Y
S
K
D
S
P
F
G
L
Site 19
S140
S
Q
P
Y
S
K
D
S
P
F
G
L
S
F
V
Site 20
S145
K
D
S
P
F
G
L
S
F
V
R
F
H
S
P
Site 21
S151
L
S
F
V
R
F
H
S
P
P
D
K
D
E
A
Site 22
T166
E
A
P
S
Q
K
V
T
V
T
K
L
G
Q
F
Site 23
S181
R
V
K
E
E
D
E
S
A
N
S
L
R
P
G
Site 24
S184
E
E
D
E
S
A
N
S
L
R
P
G
A
L
F
Site 25
S193
R
P
G
A
L
F
F
S
R
I
N
K
T
S
P
Site 26
T198
F
F
S
R
I
N
K
T
S
P
V
T
A
S
D
Site 27
S199
F
S
R
I
N
K
T
S
P
V
T
A
S
D
P
Site 28
T202
I
N
K
T
S
P
V
T
A
S
D
P
A
G
P
Site 29
S204
K
T
S
P
V
T
A
S
D
P
A
G
P
S
Y
Site 30
S210
A
S
D
P
A
G
P
S
Y
A
A
A
T
L
Q
Site 31
Y211
S
D
P
A
G
P
S
Y
A
A
A
T
L
Q
A
Site 32
S223
L
Q
A
S
S
A
A
S
S
A
S
P
V
S
R
Site 33
S224
Q
A
S
S
A
A
S
S
A
S
P
V
S
R
A
Site 34
S226
S
S
A
A
S
S
A
S
P
V
S
R
A
I
G
Site 35
S229
A
S
S
A
S
P
V
S
R
A
I
G
S
T
S
Site 36
S234
P
V
S
R
A
I
G
S
T
S
K
P
Q
E
S
Site 37
T235
V
S
R
A
I
G
S
T
S
K
P
Q
E
S
P
Site 38
S236
S
R
A
I
G
S
T
S
K
P
Q
E
S
P
K
Site 39
S241
S
T
S
K
P
Q
E
S
P
K
G
K
R
K
L
Site 40
T257
L
N
Q
E
E
K
K
T
P
S
K
P
P
A
Q
Site 41
S259
Q
E
E
K
K
T
P
S
K
P
P
A
Q
L
S
Site 42
S266
S
K
P
P
A
Q
L
S
P
S
V
P
K
R
P
Site 43
S268
P
P
A
Q
L
S
P
S
V
P
K
R
P
K
L
Site 44
T279
R
P
K
L
P
A
P
T
R
T
P
A
T
A
P
Site 45
T281
K
L
P
A
P
T
R
T
P
A
T
A
P
V
P
Site 46
T284
A
P
T
R
T
P
A
T
A
P
V
P
A
R
A
Site 47
T296
A
R
A
Q
G
A
V
T
G
K
P
R
G
E
G
Site 48
T304
G
K
P
R
G
E
G
T
E
P
R
R
P
R
A
Site 49
S336
G
F
Q
N
P
F
R
S
E
L
R
D
K
A
L
Site 50
T358
P
D
W
T
R
D
S
T
H
L
I
C
A
F
A
Site 51
S371
F
A
N
T
P
K
Y
S
Q
V
L
G
L
G
G
Site 52
S398
R
M
R
R
R
L
P
S
R
R
Y
L
M
A
G
Site 53
Y401
R
R
L
P
S
R
R
Y
L
M
A
G
P
G
S
Site 54
S408
Y
L
M
A
G
P
G
S
S
S
E
E
D
E
A
Site 55
S409
L
M
A
G
P
G
S
S
S
E
E
D
E
A
S
Site 56
S410
M
A
G
P
G
S
S
S
E
E
D
E
A
S
H
Site 57
S416
S
S
E
E
D
E
A
S
H
S
G
G
S
G
D
Site 58
S418
E
E
D
E
A
S
H
S
G
G
S
G
D
E
A
Site 59
S421
E
A
S
H
S
G
G
S
G
D
E
A
P
K
L
Site 60
T440
P
Q
T
K
T
K
P
T
Q
A
A
G
P
S
S
Site 61
S446
P
T
Q
A
A
G
P
S
S
P
Q
K
P
P
T
Site 62
S447
T
Q
A
A
G
P
S
S
P
Q
K
P
P
T
P
Site 63
T453
S
S
P
Q
K
P
P
T
P
E
E
T
K
A
A
Site 64
T457
K
P
P
T
P
E
E
T
K
A
A
S
P
V
L
Site 65
S461
P
E
E
T
K
A
A
S
P
V
L
Q
E
D
I
Site 66
S475
I
D
I
E
G
V
Q
S
E
G
Q
D
N
G
A
Site 67
S485
Q
D
N
G
A
E
D
S
G
D
T
E
D
E
L
Site 68
T488
G
A
E
D
S
G
D
T
E
D
E
L
R
R
V
Site 69
Y515
E
E
N
G
E
D
P
Y
A
G
S
T
D
E
N
Site 70
S518
G
E
D
P
Y
A
G
S
T
D
E
N
T
D
S
Site 71
T519
E
D
P
Y
A
G
S
T
D
E
N
T
D
S
E
Site 72
T523
A
G
S
T
D
E
N
T
D
S
E
E
H
Q
E
Site 73
S525
S
T
D
E
N
T
D
S
E
E
H
Q
E
P
P
Site 74
Y551
Q
G
K
H
F
F
L
Y
G
E
F
P
G
D
E
Site 75
Y565
E
R
R
K
L
I
R
Y
V
T
A
F
N
G
E
Site 76
T567
R
K
L
I
R
Y
V
T
A
F
N
G
E
L
E
Site 77
Y576
F
N
G
E
L
E
D
Y
M
S
D
R
V
Q
F
Site 78
S578
G
E
L
E
D
Y
M
S
D
R
V
Q
F
V
I
Site 79
S593
T
A
Q
E
W
D
P
S
F
E
E
A
L
M
D
Site 80
S603
E
A
L
M
D
N
P
S
L
A
F
V
R
P
R
Site 81
Y613
F
V
R
P
R
W
I
Y
S
C
N
E
K
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation