PhosphoNET

           
Protein Info 
   
Short Name:  En-2
Full Name:  Homeobox protein engrailed-2
Alias: 
Type:  Transcription protein
Mass (Da):  34211
Number AA:  333
UniProt ID:  P19622
International Prot ID:  IPI00020031
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0043565  GO:0003700   PhosphoSite+ KinaseNET
Biological Process:  GO:0006355  GO:0030901  GO:0048666 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S23EGQRQPESSPGGGSG
Site 2S24GQRQPESSPGGGSGG
Site 3S29ESSPGGGSGGGGGSS
Site 4S36SGGGGGSSPGEADTG
Site 5T42SSPGEADTGRRRALM
Site 6T87GRRKDAGTCCAGAGG
Site 7S107AGGEGGASGAEGGGG
Site 8S118GGGGAGGSEQLLGSG
Site 9S124GSEQLLGSGSREPRQ
Site 10S126EQLLGSGSREPRQNP
Site 11S148GPLPAAGSDSPGDGE
Site 12S150LPAAGSDSPGDGEGG
Site 13S158PGDGEGGSKTLSLHG
Site 14T160DGEGGSKTLSLHGGA
Site 15S162EGGSKTLSLHGGAKK
Site 16S180PGGPLDGSLKARGLG
Site 17S192GLGGGDLSVSSDSDS
Site 18S194GGGDLSVSSDSDSSQ
Site 19S195GGDLSVSSDSDSSQA
Site 20S197DLSVSSDSDSSQAGA
Site 21S199SVSSDSDSSQAGANL
Site 22S200VSSDSDSSQAGANLG
Site 23Y222AWVYCTRYSDRPSSG
Site 24S223WVYCTRYSDRPSSGP
Site 25S227TRYSDRPSSGPRSRK
Site 26S228RYSDRPSSGPRSRKP
Site 27S232RPSSGPRSRKPKKKN
Site 28T249KEDKRPRTAFTAEQL
Site 29T270FQTNRYLTEQRRQSL
Site 30S276LTEQRRQSLAQELSL
Site 31S282QSLAQELSLNESQIK
Site 32S286QELSLNESQIKIWFQ
Site 33Y319HLMAQGLYNHSTTAK
Site 34S322AQGLYNHSTTAKEGK
Site 35T323QGLYNHSTTAKEGKS
Site 36S330TTAKEGKSDSE____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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