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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP3A5
Full Name:
Cytochrome P450 3A5
Alias:
CP35; CP3A1; CP3A5; CP3AB; CYP3A1; CYPIIIA5; Cytochrome P450 HLp2; Cytochrome P450, family 3, subfamily A, polypeptide 5; Cytochrome P450-PCN3; HLp2; P450PCN3; P450-PCN3; PCN3
Type:
Xenobiotic Metabolism - drug metabolism - other enzymes; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - linoleic acid
Mass (Da):
57109
Number AA:
502
UniProt ID:
P20815
International Prot ID:
IPI00025831
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0070330
GO:0009055
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0009822
GO:0042737
GO:0070989
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
L
Y
L
Y
G
T
R
T
H
G
L
F
K
R
L
Site 2
S52
P
L
L
G
N
V
L
S
Y
R
Q
G
L
W
K
Site 3
Y68
D
T
E
C
Y
K
K
Y
G
K
M
W
G
T
Y
Site 4
T74
K
Y
G
K
M
W
G
T
Y
E
G
Q
L
P
V
Site 5
Y75
Y
G
K
M
W
G
T
Y
E
G
Q
L
P
V
L
Site 6
T92
T
D
P
D
V
I
R
T
V
L
V
K
E
C
Y
Site 7
Y99
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
Site 8
T103
K
E
C
Y
S
V
F
T
N
R
R
S
L
G
P
Site 9
S119
G
F
M
K
S
A
I
S
L
A
E
D
E
E
W
Site 10
S131
E
E
W
K
R
I
R
S
L
L
S
P
T
F
T
Site 11
S134
K
R
I
R
S
L
L
S
P
T
F
T
S
G
K
Site 12
T136
I
R
S
L
L
S
P
T
F
T
S
G
K
L
K
Site 13
T138
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
Site 14
S139
L
L
S
P
T
F
T
S
G
K
L
K
E
M
F
Site 15
S195
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
Site 16
S206
P
Q
D
P
F
V
E
S
T
K
K
F
L
K
F
Site 17
T245
V
S
L
F
P
K
D
T
I
N
F
L
S
K
S
Site 18
S250
K
D
T
I
N
F
L
S
K
S
V
N
R
M
K
Site 19
S252
T
I
N
F
L
S
K
S
V
N
R
M
K
K
S
Site 20
S278
F
L
Q
L
M
I
D
S
Q
N
S
K
E
T
E
Site 21
S281
L
M
I
D
S
Q
N
S
K
E
T
E
S
H
K
Site 22
S286
Q
N
S
K
E
T
E
S
H
K
A
L
S
D
L
Site 23
S291
T
E
S
H
K
A
L
S
D
L
E
L
A
A
Q
Site 24
Y347
P
N
K
A
P
P
T
Y
D
A
V
V
Q
M
E
Site 25
S392
G
V
F
I
P
K
G
S
M
V
V
I
P
T
Y
Site 26
Y399
S
M
V
V
I
P
T
Y
A
L
H
H
D
P
K
Site 27
Y407
A
L
H
H
D
P
K
Y
W
T
E
P
E
E
F
Site 28
S420
E
F
R
P
E
R
F
S
K
K
K
D
S
I
D
Site 29
S425
R
F
S
K
K
K
D
S
I
D
P
Y
I
Y
T
Site 30
Y429
K
K
D
S
I
D
P
Y
I
Y
T
P
F
G
T
Site 31
Y431
D
S
I
D
P
Y
I
Y
T
P
F
G
T
G
P
Site 32
T432
S
I
D
P
Y
I
Y
T
P
F
G
T
G
P
R
Site 33
S463
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Site 34
T470
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
D
Site 35
S494
P
I
V
L
K
V
D
S
R
D
G
T
L
S
G
Site 36
T498
K
V
D
S
R
D
G
T
L
S
G
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation