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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BCKDHB
Full Name:
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Alias:
2-oxoisovalerate dehydrogenase beta; BCKDH E1-beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta; E1B; EC 1.2.4.4; ODBB
Type:
Enzyme - Dehydrogenase; Mitochondria
Mass (Da):
43122
Number AA:
392
UniProt ID:
P21953
International Prot ID:
IPI00011276
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005947
Uniprot
OncoNet
Molecular Function:
GO:0003863
GO:0016831
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0009083
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T41
G
F
L
H
P
A
A
T
V
E
D
A
A
Q
R
Site 2
T55
R
R
Q
V
A
H
F
T
F
Q
P
D
P
E
P
Site 3
Y65
P
D
P
E
P
R
E
Y
G
Q
T
Q
K
M
N
Site 4
T68
E
P
R
E
Y
G
Q
T
Q
K
M
N
L
F
Q
Site 5
S76
Q
K
M
N
L
F
Q
S
V
T
S
A
L
D
N
Site 6
S84
V
T
S
A
L
D
N
S
L
A
K
D
P
T
A
Site 7
T90
N
S
L
A
K
D
P
T
A
V
I
F
G
E
D
Site 8
Y114
T
V
G
L
R
D
K
Y
G
K
D
R
V
F
N
Site 9
T122
G
K
D
R
V
F
N
T
P
L
C
E
Q
G
I
Site 10
Y167
I
V
N
E
A
A
K
Y
R
Y
R
S
G
D
L
Site 11
S171
A
A
K
Y
R
Y
R
S
G
D
L
F
N
C
G
Site 12
S179
G
D
L
F
N
C
G
S
L
T
I
R
S
P
W
Site 13
Y195
C
V
G
H
G
A
L
Y
H
S
Q
S
P
E
A
Site 14
S197
G
H
G
A
L
Y
H
S
Q
S
P
E
A
F
F
Site 15
S199
G
A
L
Y
H
S
Q
S
P
E
A
F
F
A
H
Site 16
S227
Q
A
K
G
L
L
L
S
C
I
E
D
K
N
P
Site 17
Y256
E
E
V
P
I
E
P
Y
N
I
P
L
S
Q
A
Site 18
S261
E
P
Y
N
I
P
L
S
Q
A
E
V
I
Q
E
Site 19
T273
I
Q
E
G
S
D
V
T
L
V
A
W
G
T
Q
Site 20
S318
D
V
D
T
I
C
K
S
V
I
K
T
G
R
L
Site 21
S328
K
T
G
R
L
L
I
S
H
E
A
P
L
T
G
Site 22
S343
G
F
A
S
E
I
S
S
T
V
Q
E
E
C
F
Site 23
S358
L
N
L
E
A
P
I
S
R
V
C
G
Y
D
T
Site 24
Y363
P
I
S
R
V
C
G
Y
D
T
P
F
P
H
I
Site 25
T365
S
R
V
C
G
Y
D
T
P
F
P
H
I
F
E
Site 26
Y383
I
P
D
K
W
K
C
Y
D
A
L
R
K
M
I
Site 27
Y392
A
L
R
K
M
I
N
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation