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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAICS
Full Name:
Multifunctional protein ADE2
Alias:
ADE2; ADE2H1; ADE2PUR6; AIR carboxylase; AIRC; EC 4.1.1.21; EC 6.3.2.6; Multifunctional protein ADE2; Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase; PAIS; Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; PUR6; SAICAR synthetase
Type:
EC 4.1.1.21; Lyase; Ligase; Nucleotide Metabolism - purine; EC 6.3.2.6
Mass (Da):
47079
Number AA:
425
UniProt ID:
P22234
International Prot ID:
IPI00217223
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0004638
PhosphoSite+
KinaseNET
Biological Process:
GO:0006189
GO:0009113
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
K
K
L
Y
E
G
K
T
K
E
V
Y
E
L
L
Site 2
Y22
E
G
K
T
K
E
V
Y
E
L
L
D
S
P
G
Site 3
S27
E
V
Y
E
L
L
D
S
P
G
K
V
L
L
Q
Site 4
S35
P
G
K
V
L
L
Q
S
K
D
Q
I
T
A
G
Site 5
T40
L
Q
S
K
D
Q
I
T
A
G
N
A
A
R
K
Site 6
T84
F
T
R
K
C
G
E
T
A
F
I
A
P
Q
C
Site 7
T105
W
V
C
R
R
I
A
T
G
S
F
L
K
R
N
Site 8
S107
C
R
R
I
A
T
G
S
F
L
K
R
N
P
G
Site 9
Y122
V
K
E
G
Y
K
F
Y
P
P
K
V
E
L
F
Site 10
S219
D
S
W
R
L
W
P
S
G
D
R
S
Q
Q
K
Site 11
S223
L
W
P
S
G
D
R
S
Q
Q
K
D
K
Q
S
Site 12
S230
S
Q
Q
K
D
K
Q
S
Y
R
D
L
K
E
V
Site 13
Y231
Q
Q
K
D
K
Q
S
Y
R
D
L
K
E
V
T
Site 14
T238
Y
R
D
L
K
E
V
T
P
E
G
L
Q
M
V
Site 15
S262
R
V
E
L
L
L
K
S
E
S
Q
C
R
V
V
Site 16
T300
I
P
C
E
L
R
V
T
S
A
H
K
G
P
D
Site 17
S301
P
C
E
L
R
V
T
S
A
H
K
G
P
D
E
Site 18
T309
A
H
K
G
P
D
E
T
L
R
I
K
A
E
Y
Site 19
Y316
T
L
R
I
K
A
E
Y
E
G
D
G
I
P
T
Site 20
Y345
V
M
S
G
N
T
A
Y
P
V
I
S
C
P
P
Site 21
S349
N
T
A
Y
P
V
I
S
C
P
P
L
T
P
D
Site 22
T354
V
I
S
C
P
P
L
T
P
D
W
G
V
Q
D
Site 23
S364
W
G
V
Q
D
V
W
S
S
L
R
L
P
S
G
Site 24
S365
G
V
Q
D
V
W
S
S
L
R
L
P
S
G
L
Site 25
T376
P
S
G
L
G
C
S
T
V
L
S
P
E
G
S
Site 26
S394
A
A
Q
I
F
G
L
S
N
H
L
V
W
S
K
Site 27
S400
L
S
N
H
L
V
W
S
K
L
R
A
S
I
L
Site 28
S412
S
I
L
N
T
W
I
S
L
K
Q
A
D
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation