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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv1.4
Full Name:
Potassium voltage-gated channel subfamily A member 4
Alias:
2; HBK4; HK1; HPCN2; HUKII; HuKII; KCNA4; KCNA4L; Potassium voltage-gated channel, shaker-related subfamily, member 4; Voltage-gated potassium channel subunit Kv1.4
Type:
Channel protein, potassium
Mass (Da):
73288
Number AA:
653
UniProt ID:
P22459
International Prot ID:
IPI00304582
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0005515
GO:0005249
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
A
M
V
S
A
E
S
S
G
C
N
S
H
M
P
Site 2
Y19
G
C
N
S
H
M
P
Y
G
Y
A
A
Q
A
R
Site 3
S36
E
R
E
R
L
A
H
S
R
R
A
A
A
R
A
Site 4
S57
A
V
E
G
S
G
G
S
G
G
G
S
H
H
H
Site 5
S61
S
G
G
S
G
G
G
S
H
H
H
H
Q
S
R
Site 6
S73
Q
S
R
G
A
C
T
S
H
D
P
Q
S
S
R
Site 7
S78
C
T
S
H
D
P
Q
S
S
R
G
S
R
E
E
Site 8
S82
D
P
Q
S
S
R
G
S
R
E
E
E
A
T
R
Site 9
T88
G
S
R
E
E
E
A
T
R
S
E
K
K
K
A
Site 10
S90
R
E
E
E
A
T
R
S
E
K
K
K
A
H
Y
Site 11
Y97
S
E
K
K
K
A
H
Y
R
Q
S
S
F
P
H
Site 12
S100
K
K
A
H
Y
R
Q
S
S
F
P
H
C
S
D
Site 13
S101
K
A
H
Y
R
Q
S
S
F
P
H
C
S
D
L
Site 14
S106
Q
S
S
F
P
H
C
S
D
L
M
P
S
G
S
Site 15
S111
H
C
S
D
L
M
P
S
G
S
E
E
K
I
L
Site 16
S113
S
D
L
M
P
S
G
S
E
E
K
I
L
R
E
Site 17
S122
E
K
I
L
R
E
L
S
E
E
E
E
D
E
E
Site 18
Y141
E
E
E
E
G
R
F
Y
Y
S
E
D
D
H
G
Site 19
Y142
E
E
E
G
R
F
Y
Y
S
E
D
D
H
G
D
Site 20
S152
D
D
H
G
D
E
C
S
Y
T
D
L
L
P
Q
Site 21
Y153
D
H
G
D
E
C
S
Y
T
D
L
L
P
Q
D
Site 22
T154
H
G
D
E
C
S
Y
T
D
L
L
P
Q
D
E
Site 23
S167
D
E
G
G
G
G
Y
S
S
V
R
Y
S
D
C
Site 24
S168
E
G
G
G
G
Y
S
S
V
R
Y
S
D
C
C
Site 25
Y171
G
G
Y
S
S
V
R
Y
S
D
C
C
E
R
V
Site 26
S172
G
Y
S
S
V
R
Y
S
D
C
C
E
R
V
V
Site 27
S183
E
R
V
V
I
N
V
S
G
L
R
F
E
T
Q
Site 28
T189
V
S
G
L
R
F
E
T
Q
M
K
T
L
A
Q
Site 29
T193
R
F
E
T
Q
M
K
T
L
A
Q
F
P
E
T
Site 30
T200
T
L
A
Q
F
P
E
T
L
L
G
D
P
E
K
Site 31
T209
L
G
D
P
E
K
R
T
Q
Y
F
D
P
L
R
Site 32
Y211
D
P
E
K
R
T
Q
Y
F
D
P
L
R
N
E
Site 33
Y219
F
D
P
L
R
N
E
Y
F
F
D
R
N
R
P
Site 34
S227
F
F
D
R
N
R
P
S
F
D
A
I
L
Y
Y
Site 35
Y233
P
S
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
Site 36
Y234
S
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
L
Site 37
Y235
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
L
K
Site 38
S237
A
I
L
Y
Y
Y
Q
S
G
G
R
L
K
R
P
Site 39
T253
N
V
P
F
D
I
F
T
E
E
V
K
F
Y
Q
Site 40
Y259
F
T
E
E
V
K
F
Y
Q
L
G
E
E
A
L
Site 41
Y299
Q
I
W
L
L
F
E
Y
P
E
S
S
D
P
A
Site 42
S302
L
L
F
E
Y
P
E
S
S
D
P
A
R
G
I
Site 43
S303
L
F
E
Y
P
E
S
S
D
P
A
R
G
I
A
Site 44
T354
H
G
G
L
L
N
D
T
S
A
P
H
L
E
N
Site 45
S355
G
G
L
L
N
D
T
S
A
P
H
L
E
N
S
Site 46
S458
V
F
R
I
F
K
L
S
R
H
S
K
G
L
Q
Site 47
S461
I
F
K
L
S
R
H
S
K
G
L
Q
I
L
G
Site 48
T470
G
L
Q
I
L
G
H
T
L
R
A
S
M
R
E
Site 49
T506
A
E
A
D
E
P
T
T
H
F
Q
S
I
P
D
Site 50
S561
L
P
V
P
V
I
V
S
N
F
N
Y
F
Y
H
Site 51
Y565
V
I
V
S
N
F
N
Y
F
Y
H
R
E
T
E
Site 52
Y567
V
S
N
F
N
Y
F
Y
H
R
E
T
E
N
E
Site 53
S585
Q
L
T
Q
N
A
V
S
C
P
Y
L
P
S
N
Site 54
Y588
Q
N
A
V
S
C
P
Y
L
P
S
N
L
L
K
Site 55
S591
V
S
C
P
Y
L
P
S
N
L
L
K
K
F
R
Site 56
S599
N
L
L
K
K
F
R
S
S
T
S
S
S
L
G
Site 57
S600
L
L
K
K
F
R
S
S
T
S
S
S
L
G
D
Site 58
T601
L
K
K
F
R
S
S
T
S
S
S
L
G
D
K
Site 59
S602
K
K
F
R
S
S
T
S
S
S
L
G
D
K
S
Site 60
S603
K
F
R
S
S
T
S
S
S
L
G
D
K
S
E
Site 61
S604
F
R
S
S
T
S
S
S
L
G
D
K
S
E
Y
Site 62
S609
S
S
S
L
G
D
K
S
E
Y
L
E
M
E
E
Site 63
Y611
S
L
G
D
K
S
E
Y
L
E
M
E
E
G
V
Site 64
S621
M
E
E
G
V
K
E
S
L
C
A
K
E
E
K
Site 65
S636
C
Q
A
K
G
D
D
S
E
T
D
K
N
N
C
Site 66
T638
A
K
G
D
D
S
E
T
D
K
N
N
C
S
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation