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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKACbeta
Full Name:
cAMP-dependent protein kinase catalytic subunit beta
Alias:
EC 2.7.11.11; KAPB; KAPB1; KAPCB; PKA C-beta; PKA-beta
Type:
Protein-serine kinase, AGC group, PKA family
Mass (Da):
40492
Number AA:
350
UniProt ID:
P22694
International Prot ID:
IPI00395654
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005952
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004691
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007188
GO:0034199
GO:0009755
Phosida
TranscriptoNet
STRING
Kinexus Products
CREB1 (123-135) KinSub - cyclic-AMP response element binding protein-1 (K123-R135, human) peptide; Crebtide protein kinase substrate peptide - Powder PE-01ACP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACP95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
A
A
T
A
K
K
G
S
E
V
E
S
V
K
E
Site 2
S15
K
K
G
S
E
V
E
S
V
K
E
F
L
A
K
Site 3
T49
E
D
F
E
R
K
K
T
L
G
T
G
S
F
G
Site 4
Y69
K
H
K
A
T
E
Q
Y
Y
A
M
K
I
L
D
Site 5
Y70
H
K
A
T
E
Q
Y
Y
A
M
K
I
L
D
K
Site 6
Y109
P
F
L
V
R
L
E
Y
A
F
K
D
N
S
N
Site 7
Y118
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
Site 8
Y123
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
Site 9
S131
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
Site 10
S140
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
Site 11
S160
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
Site 12
Y165
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
Site 13
T196
A
K
R
V
K
G
R
T
W
T
L
C
G
T
P
Site 14
T198
R
V
K
G
R
T
W
T
L
C
G
T
P
E
Y
Site 15
T202
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
Site 16
Y205
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
Site 17
Y248
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
Site 18
S253
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
Site 19
S260
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
Site 20
S264
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
Site 21
T279
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
Site 22
S290
G
N
L
K
N
G
V
S
D
I
K
T
H
K
W
Site 23
T294
N
G
V
S
D
I
K
T
H
K
W
F
A
T
T
Site 24
Y307
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
Site 25
S322
F
I
P
K
F
R
G
S
G
D
T
S
N
F
D
Site 26
T325
K
F
R
G
S
G
D
T
S
N
F
D
D
Y
E
Site 27
S326
F
R
G
S
G
D
T
S
N
F
D
D
Y
E
E
Site 28
Y331
D
T
S
N
F
D
D
Y
E
E
E
D
I
R
V
Site 29
S339
E
E
E
D
I
R
V
S
I
T
E
K
C
A
K
Site 30
T341
E
D
I
R
V
S
I
T
E
K
C
A
K
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation