KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ITPKA
Full Name:
Inositol-trisphosphate 3-kinase A
Alias:
Inositol 1,4,5-trisphosphate 3-kinase A
Type:
Kinase, lipid
Mass (Da):
51009
Number AA:
461
UniProt ID:
P23677
International Prot ID:
IPI00012538
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005516
GO:0008440
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
P
G
G
A
R
P
C
S
P
G
L
E
R
A
P
Site 2
S30
L
E
R
A
P
R
R
S
V
G
E
L
R
L
L
Site 3
T83
A
P
V
I
P
Q
L
T
V
T
A
E
E
P
D
Site 4
T94
E
E
P
D
V
P
P
T
S
P
G
P
P
E
R
Site 5
S95
E
P
D
V
P
P
T
S
P
G
P
P
E
R
E
Site 6
S111
D
C
L
P
A
A
G
S
S
H
L
Q
Q
P
R
Site 7
S121
L
Q
Q
P
R
R
L
S
T
S
S
V
S
S
T
Site 8
T122
Q
Q
P
R
R
L
S
T
S
S
V
S
S
T
G
Site 9
S123
Q
P
R
R
L
S
T
S
S
V
S
S
T
G
S
Site 10
S124
P
R
R
L
S
T
S
S
V
S
S
T
G
S
S
Site 11
S126
R
L
S
T
S
S
V
S
S
T
G
S
S
S
L
Site 12
T128
S
T
S
S
V
S
S
T
G
S
S
S
L
L
E
Site 13
S130
S
S
V
S
S
T
G
S
S
S
L
L
E
D
S
Site 14
S131
S
V
S
S
T
G
S
S
S
L
L
E
D
S
E
Site 15
S132
V
S
S
T
G
S
S
S
L
L
E
D
S
E
D
Site 16
S137
S
S
S
L
L
E
D
S
E
D
D
L
L
S
D
Site 17
S143
D
S
E
D
D
L
L
S
D
S
E
S
R
S
R
Site 18
S145
E
D
D
L
L
S
D
S
E
S
R
S
R
G
N
Site 19
S147
D
L
L
S
D
S
E
S
R
S
R
G
N
V
Q
Site 20
S149
L
S
D
S
E
S
R
S
R
G
N
V
Q
L
E
Site 21
S180
M
V
N
L
P
V
I
S
P
F
K
K
R
Y
A
Site 22
Y186
I
S
P
F
K
K
R
Y
A
W
V
Q
L
A
G
Site 23
S197
Q
L
A
G
H
T
G
S
F
K
A
A
G
T
S
Site 24
S212
G
L
I
L
K
R
C
S
E
P
E
R
Y
C
L
Site 25
Y217
R
C
S
E
P
E
R
Y
C
L
A
R
L
M
A
Site 26
Y245
V
E
R
D
G
E
S
Y
L
Q
L
Q
D
L
L
Site 27
Y270
C
K
M
G
V
R
T
Y
L
E
E
E
L
T
K
Site 28
T276
T
Y
L
E
E
E
L
T
K
A
R
E
R
P
K
Site 29
Y289
P
K
L
R
K
D
M
Y
K
K
M
L
A
V
D
Site 30
T311
E
H
A
Q
R
A
V
T
K
P
R
Y
M
Q
W
Site 31
Y315
R
A
V
T
K
P
R
Y
M
Q
W
R
E
G
I
Site 32
S323
M
Q
W
R
E
G
I
S
S
S
T
T
L
G
F
Site 33
S324
Q
W
R
E
G
I
S
S
S
T
T
L
G
F
R
Site 34
S325
W
R
E
G
I
S
S
S
T
T
L
G
F
R
I
Site 35
T327
E
G
I
S
S
S
T
T
L
G
F
R
I
E
G
Site 36
S343
K
K
A
D
G
S
C
S
T
D
F
K
T
T
R
Site 37
T348
S
C
S
T
D
F
K
T
T
R
S
R
E
Q
V
Site 38
S351
T
D
F
K
T
T
R
S
R
E
Q
V
L
R
V
Site 39
Y373
D
E
E
V
L
R
R
Y
L
N
R
L
Q
Q
I
Site 40
T383
R
L
Q
Q
I
R
D
T
L
E
V
S
E
F
F
Site 41
S387
I
R
D
T
L
E
V
S
E
F
F
R
R
H
E
Site 42
S398
R
R
H
E
V
I
G
S
S
L
L
F
V
H
D
Site 43
T421
L
I
D
F
G
K
T
T
P
L
P
D
G
Q
I
Site 44
Y444
E
G
N
R
E
D
G
Y
L
L
G
L
D
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation