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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cyclin D1
Full Name:
G1/S-specific cyclin-D1
Alias:
BCL1; CCND1; CYL-1; G1,S-specific cyclin D1; PRAD1
Type:
Protein-serine kinase regulatory subunit, activator, cyclin
Mass (Da):
33729
Number AA:
295
UniProt ID:
P24385
International Prot ID:
IPI00028098
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000307
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0019901
PhosphoSite+
KinaseNET
Biological Process:
GO:0031571
GO:0000082
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
L
L
C
C
E
V
E
T
I
R
R
A
Y
P
D
Site 2
Y17
V
E
T
I
R
R
A
Y
P
D
A
N
L
L
N
Site 3
T37
A
M
L
K
A
E
E
T
C
A
P
S
V
S
Y
Site 4
S90
N
Y
L
D
R
F
L
S
L
E
P
V
K
K
S
Site 5
Y127
T
A
E
K
L
C
I
Y
T
D
N
S
I
R
P
Site 6
S131
L
C
I
Y
T
D
N
S
I
R
P
E
E
L
L
Site 7
S166
D
F
I
E
H
F
L
S
K
M
P
E
A
E
E
Site 8
S197
A
T
D
V
K
F
I
S
N
P
P
S
M
V
A
Site 9
S219
V
Q
G
L
N
L
R
S
P
N
N
F
L
S
Y
Site 10
S225
R
S
P
N
N
F
L
S
Y
Y
R
L
T
R
F
Site 11
Y226
S
P
N
N
F
L
S
Y
Y
R
L
T
R
F
L
Site 12
Y227
P
N
N
F
L
S
Y
Y
R
L
T
R
F
L
S
Site 13
S234
Y
R
L
T
R
F
L
S
R
V
I
K
C
D
P
Site 14
S258
I
E
A
L
L
E
S
S
L
R
Q
A
Q
Q
N
Site 15
T286
E
E
V
D
L
A
C
T
P
T
D
V
R
D
V
Site 16
T288
V
D
L
A
C
T
P
T
D
V
R
D
V
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation