|
|
|
|
|
|
|
|
|
|
|
|
Protein Info
|
|
|
|
|
|
Short Name:
|
CDK2
|
|
Full Name:
|
Cell division protein kinase 2
|
|
Alias:
|
Cyclin-dependent kinase 2; EC 2.7.11.22; Kinase Cdk2; P33 protein kinase
|
|
Type:
|
EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK1 subfamily; CDK/CDK1 subfamily
|
|
Mass (Da):
|
33930
|
|
Number AA:
|
298
|
|
UniProt ID:
|
P24941
|
|
International Prot ID:
|
IPI00031681
|
|
Sequence:
|
Retrieve full protein sequence
|
|
|
|
|
GO Terms
|
|
External Links
|
Internal Links
|
|
|
|
|
|
Cellular Component:
|
GO:0000307
GO:0005829
|
Uniprot
|
OncoNet
|
|
Molecular Function:
|
GO:0005524
GO:0004693
GO:0042802
|
PhosphoSite+
|
KinaseNET
|
|
|
Biological Process:
|
GO:0006260
GO:0000086
GO:0051301
|
Phosida
|
TranscriptoNet
|
|
|
|
|
STRING
|
Kinexus Products
Cyclin-dependent protein-serine kinase 2 T160 phosphosite-specific antibody AB-PK568#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK568#RNA polymerase II-CT KinSub - heptapeptide repeat from C-terminus peptide; CDKtide protein kinase substrate peptide - Powder PE-01ADN95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADN95#CDK1-3 Selectide - CDK1 (CDC2) protein kinase substrate peptide - Powder PE-01BGO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BGO99#Cyclin-dependent protein-serine kinase 2 (R157-V163, human) pT160 phosphopeptide - Powder PE-04ADY95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADY95#Cyclin-dependent protein-serine kinase 2 (P155-V163, human) pT158+pY159+pT160 phosphopeptide - Powder PE-04ASK95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ASK95#Cyclin-dependent protein-serine kinase 2 (E162-A170, human) pT165+pY168 phosphopeptide - Powder PE-04ASL01#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ASL01
|
|
|
|
|
Info Box
|
|
A variety of parameters were considered in the selection of putative P-sites.
Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score
is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr
or P-Tyr sites. The Maximum KInase Score provides the calculated score for
highest match of 500 human protein kinases for the amino acid sequence
surrounding the target P-site as determined with Kinase Substrate Predictor V2.
The Sum KInase Score provides the additive sum of the positive individual Kinase
Substrate Predictor V2 scores from 500 human protein kinases. The Conservation
Score is the average of the percent similarity of the human P-site with the
equivalent P-site in 20 other diverse species. Click the coloured buttons below
to retrieve this and other information in the Info Box, or click the orange
buttons for relevant links. |
|
| Phosphosites | |
| |
| | | -7 | -6 | -5 | -4 | -3 | -2 | -1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Expt. conf. | Effect | Kinase | PPase | Kinexus Products | | Ref. | Evol. | Kinase Pred. | P-site Match |
| | Site 1 | T14 | V | E | K | I | G | E | G | T | Y | G | V | V | Y | K | A | |  | |  | | | |  | | | |
| | Site 2 | Y15 | E | K | I | G | E | G | T | Y | G | V | V | Y | K | A | R | | | | | | | | | | | |
| | Site 3 | Y19 | E | G | T | Y | G | V | V | Y | K | A | R | N | K | L | T | | | | | | | | | | | |
| | Site 4 | T39 | L | K | K | I | R | L | D | T | E | T | E | G | V | P | S | | | | | | | | | | | |
| | Site 5 | T41 | K | I | R | L | D | T | E | T | E | G | V | P | S | T | A | |  | | | | | | | | | |
| | Site 6 | S46 | T | E | T | E | G | V | P | S | T | A | I | R | E | I | S | | | | | | | | | | | |
| | Site 7 | T47 | E | T | E | G | V | P | S | T | A | I | R | E | I | S | L | | | | | | | | | | | |
| | Site 8 | S53 | S | T | A | I | R | E | I | S | L | L | K | E | L | N | H | | | | | | | | | | | |
| | Site 9 | T72 | K | L | L | D | V | I | H | T | E | N | K | L | Y | L | V | | | | | | | | | | | |
| | Site 10 | Y77 | I | H | T | E | N | K | L | Y | L | V | F | E | F | L | H | | | | | | | | | | | |
| | Site 11 | T137 | P | Q | N | L | L | I | N | T | E | G | A | I | K | L | A | | | | | | | | | | | |
| | Site 12 | T158 | A | F | G | V | P | V | R | T | Y | T | H | E | V | V | T | | | | | |  Cyclin-dependent protein-serine kinase 2 (P155-V163, human) pT158+pY159+pT160 phosphopeptide - Powder PE-04ASK95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ASK95 | | | | | |
| | Site 13 | Y159 | F | G | V | P | V | R | T | Y | T | H | E | V | V | T | L | | | | | | Cyclin-dependent protein-serine kinase 2 (P155-V163, human) pT158+pY159+pT160 phosphopeptide - Powder PE-04ASK95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ASK95 | | | | | |
| | Site 14 | T160 | G | V | P | V | R | T | Y | T | H | E | V | V | T | L | W | | | | | | Cyclin-dependent protein-serine kinase 2 T160 phosphosite-specific antibody AB-PK568#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK568#Cyclin-dependent protein-serine kinase 2 (R157-V163, human) pT160 phosphopeptide - Powder PE-04ADY95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADY95#Cyclin-dependent protein-serine kinase 2 (P155-V163, human) pT158+pY159+pT160 phosphopeptide - Powder PE-04ASK95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ASK95 | | | | | |
| | Site 15 | T165 | T | Y | T | H | E | V | V | T | L | W | Y | R | A | P | E | | | | | | Cyclin-dependent protein-serine kinase 2 (E162-A170, human) pT165+pY168 phosphopeptide - Powder PE-04ASL01#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ASL01 | | | | | |
| | Site 16 | Y168 | H | E | V | V | T | L | W | Y | R | A | P | E | I | L | L | | | | | | Cyclin-dependent protein-serine kinase 2 (E162-A170, human) pT165+pY168 phosphopeptide - Powder PE-04ASL01#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ASL01 | | | | | |
| | Site 17 | Y179 | E | I | L | L | G | C | K | Y | Y | S | T | A | V | D | I | | | | | | | | | | | |
| | Site 18 | S207 | R | A | L | F | P | G | D | S | E | I | D | Q | L | F | R | | | | | | | | | | | |
| | Site 19 | T221 | R | I | F | R | T | L | G | T | P | D | E | V | V | W | P | | | | | | | | | | | |
| | Site 20 | Y236 | G | V | T | S | M | P | D | Y | K | P | S | F | P | K | W | | | | | | | | | | | |
| | Site 21 | S239 | S | M | P | D | Y | K | P | S | F | P | K | W | A | R | Q | | | | | | | | | | | |
| | Site 22 | S249 | K | W | A | R | Q | D | F | S | K | V | V | P | P | L | D | | | | | | | | | | | |
| | Site 23 | S261 | P | L | D | E | D | G | R | S | L | L | S | Q | M | L | H | | | | | | | | | | | |
| | Site 24 | S264 | E | D | G | R | S | L | L | S | Q | M | L | H | Y | D | P | | | | | | | | | | | |
| | Site 25 | Y269 | L | L | S | Q | M | L | H | Y | D | P | N | K | R | I | S | | | | | | | | | | | |
| | Site 26 | S276 | Y | D | P | N | K | R | I | S | A | K | A | A | L | A | H | | | | | | | | | | | |
| | Site 27 | T290 | H | P | F | F | Q | D | V | T | K | P | V | P | H | L | R | | | | | | | | | | | |
|
|
|
|
|
|
|
|
Legend
|
|
|
|
Confirmed in mammals
|
|
Confirmed in related proteins or other species
|
|
|
Predicted by Kinexus P-Site Prediction algorithm
|
|
|
No data/link available
|
|
|
Link available
|
|
|
Products available
|
|
|
|
|
|
|