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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCM3
Full Name:
DNA replication licensing factor MCM3
Alias:
DNA replication licensing factor MCM3; MCMD; MCMD3; Minichromosome maintenance complex component 3; P102 protein; P1-MCM3; RLF beta subunit
Type:
DNA binding protein
Mass (Da):
90981
Number AA:
808
UniProt ID:
P25205
International Prot ID:
IPI00013214
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005658
GO:0005813
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0017111
PhosphoSite+
KinaseNET
Biological Process:
GO:0006270
GO:0007049
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
A
G
T
V
V
L
D
D
V
E
Site 2
Y19
L
R
E
A
Q
R
D
Y
L
D
F
L
D
D
E
Site 3
Y32
D
E
E
D
Q
G
I
Y
Q
S
K
V
R
E
L
Site 4
S34
E
D
Q
G
I
Y
Q
S
K
V
R
E
L
I
S
Site 5
S41
S
K
V
R
E
L
I
S
D
N
Q
Y
R
L
I
Site 6
Y45
E
L
I
S
D
N
Q
Y
R
L
I
V
N
V
N
Site 7
T90
F
V
A
S
I
D
A
T
Y
A
K
Q
Y
E
E
Site 8
Y91
V
A
S
I
D
A
T
Y
A
K
Q
Y
E
E
F
Site 9
Y99
A
K
Q
Y
E
E
F
Y
V
G
L
E
G
S
F
Site 10
S105
F
Y
V
G
L
E
G
S
F
G
S
K
H
V
S
Site 11
S108
G
L
E
G
S
F
G
S
K
H
V
S
P
R
T
Site 12
S112
S
F
G
S
K
H
V
S
P
R
T
L
T
S
C
Site 13
T115
S
K
H
V
S
P
R
T
L
T
S
C
F
L
S
Site 14
S144
V
R
P
K
V
V
R
S
V
H
Y
C
P
A
T
Site 15
T154
Y
C
P
A
T
K
K
T
I
E
R
R
Y
S
D
Site 16
Y159
K
K
T
I
E
R
R
Y
S
D
L
T
T
L
V
Site 17
S160
K
T
I
E
R
R
Y
S
D
L
T
T
L
V
A
Site 18
T163
E
R
R
Y
S
D
L
T
T
L
V
A
F
P
S
Site 19
T164
R
R
Y
S
D
L
T
T
L
V
A
F
P
S
S
Site 20
S170
T
T
L
V
A
F
P
S
S
S
V
Y
P
T
K
Site 21
S171
T
L
V
A
F
P
S
S
S
V
Y
P
T
K
D
Site 22
S172
L
V
A
F
P
S
S
S
V
Y
P
T
K
D
E
Site 23
Y174
A
F
P
S
S
S
V
Y
P
T
K
D
E
E
N
Site 24
T176
P
S
S
S
V
Y
P
T
K
D
E
E
N
N
P
Site 25
S191
L
E
T
E
Y
G
L
S
V
Y
K
D
H
Q
T
Site 26
T198
S
V
Y
K
D
H
Q
T
I
T
I
Q
E
M
P
Site 27
S216
P
A
G
Q
L
P
R
S
V
D
V
I
L
D
D
Site 28
T240
D
R
V
Q
V
V
G
T
Y
R
C
L
P
G
K
Site 29
Y241
R
V
Q
V
V
G
T
Y
R
C
L
P
G
K
K
Site 30
S253
G
K
K
G
G
Y
T
S
G
T
F
R
T
V
L
Site 31
T255
K
G
G
Y
T
S
G
T
F
R
T
V
L
I
A
Site 32
T258
Y
T
S
G
T
F
R
T
V
L
I
A
C
N
V
Site 33
S275
M
S
K
D
A
Q
P
S
F
S
A
E
D
I
A
Site 34
S288
I
A
K
I
K
K
F
S
K
T
R
S
K
D
I
Site 35
T290
K
I
K
K
F
S
K
T
R
S
K
D
I
F
D
Site 36
S292
K
K
F
S
K
T
R
S
K
D
I
F
D
Q
L
Site 37
S306
L
A
K
S
L
A
P
S
I
H
G
H
D
Y
V
Site 38
Y312
P
S
I
H
G
H
D
Y
V
K
K
A
I
L
C
Site 39
S352
G
D
P
S
V
A
K
S
Q
L
L
R
Y
V
L
Site 40
Y357
A
K
S
Q
L
L
R
Y
V
L
C
T
A
P
R
Site 41
T368
T
A
P
R
A
I
P
T
T
G
R
G
S
S
G
Site 42
T369
A
P
R
A
I
P
T
T
G
R
G
S
S
G
V
Site 43
S374
P
T
T
G
R
G
S
S
G
V
G
L
T
A
A
Site 44
T420
K
M
S
D
M
D
R
T
A
I
H
E
V
M
E
Site 45
Y456
L
A
A
A
N
P
V
Y
G
R
Y
D
Q
Y
K
Site 46
Y462
V
Y
G
R
Y
D
Q
Y
K
T
P
M
E
N
I
Site 47
T464
G
R
Y
D
Q
Y
K
T
P
M
E
N
I
G
L
Site 48
S474
E
N
I
G
L
Q
D
S
L
L
S
R
F
D
L
Site 49
S498
P
E
Q
D
R
E
I
S
D
H
V
L
R
M
H
Site 50
Y507
H
V
L
R
M
H
R
Y
R
A
P
G
E
Q
D
Site 51
T529
S
A
V
D
I
L
A
T
D
D
P
N
F
S
Q
Site 52
S535
A
T
D
D
P
N
F
S
Q
E
D
Q
Q
D
T
Site 53
T542
S
Q
E
D
Q
Q
D
T
Q
I
Y
E
K
H
D
Site 54
Y545
D
Q
Q
D
T
Q
I
Y
E
K
H
D
N
L
L
Site 55
Y589
L
T
Q
E
S
A
T
Y
I
A
E
E
Y
S
R
Site 56
Y594
A
T
Y
I
A
E
E
Y
S
R
L
R
S
Q
D
Site 57
S595
T
Y
I
A
E
E
Y
S
R
L
R
S
Q
D
S
Site 58
S599
E
E
Y
S
R
L
R
S
Q
D
S
M
S
S
D
Site 59
S602
S
R
L
R
S
Q
D
S
M
S
S
D
T
A
R
Site 60
S604
L
R
S
Q
D
S
M
S
S
D
T
A
R
T
S
Site 61
S605
R
S
Q
D
S
M
S
S
D
T
A
R
T
S
P
Site 62
T607
Q
D
S
M
S
S
D
T
A
R
T
S
P
V
T
Site 63
S611
S
S
D
T
A
R
T
S
P
V
T
A
R
T
L
Site 64
T614
T
A
R
T
S
P
V
T
A
R
T
L
E
T
L
Site 65
T617
T
S
P
V
T
A
R
T
L
E
T
L
I
R
L
Site 66
T626
E
T
L
I
R
L
A
T
A
H
A
K
A
R
M
Site 67
S634
A
H
A
K
A
R
M
S
K
T
V
D
L
Q
D
Site 68
T636
A
K
A
R
M
S
K
T
V
D
L
Q
D
A
E
Site 69
Y651
E
A
V
E
L
V
Q
Y
A
Y
F
K
K
V
L
Site 70
Y653
V
E
L
V
Q
Y
A
Y
F
K
K
V
L
E
K
Site 71
S668
E
K
K
R
K
K
R
S
E
D
E
S
E
T
E
Site 72
S672
K
K
R
S
E
D
E
S
E
T
E
D
E
E
E
Site 73
T674
R
S
E
D
E
S
E
T
E
D
E
E
E
K
S
Site 74
S681
T
E
D
E
E
E
K
S
Q
E
D
Q
E
Q
K
Site 75
T694
Q
K
R
K
R
R
K
T
R
Q
P
D
A
K
D
Site 76
S704
P
D
A
K
D
G
D
S
Y
D
P
Y
D
F
S
Site 77
Y705
D
A
K
D
G
D
S
Y
D
P
Y
D
F
S
D
Site 78
Y708
D
G
D
S
Y
D
P
Y
D
F
S
D
T
E
E
Site 79
S711
S
Y
D
P
Y
D
F
S
D
T
E
E
E
M
P
Site 80
T713
D
P
Y
D
F
S
D
T
E
E
E
M
P
Q
V
Site 81
T722
E
E
M
P
Q
V
H
T
P
K
T
A
D
S
Q
Site 82
T725
P
Q
V
H
T
P
K
T
A
D
S
Q
E
T
K
Site 83
S728
H
T
P
K
T
A
D
S
Q
E
T
K
E
S
Q
Site 84
S734
D
S
Q
E
T
K
E
S
Q
K
V
E
L
S
E
Site 85
S740
E
S
Q
K
V
E
L
S
E
S
R
L
K
A
F
Site 86
S742
Q
K
V
E
L
S
E
S
R
L
K
A
F
K
V
Site 87
T769
S
I
G
M
N
R
L
T
E
S
I
N
R
D
S
Site 88
S771
G
M
N
R
L
T
E
S
I
N
R
D
S
E
E
Site 89
S776
T
E
S
I
N
R
D
S
E
E
P
F
S
S
V
Site 90
S781
R
D
S
E
E
P
F
S
S
V
E
I
Q
A
A
Site 91
S782
D
S
E
E
P
F
S
S
V
E
I
Q
A
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation