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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN3
Full Name:
Tyrosine-protein phosphatase non-receptor type 3
Alias:
EC 3.1.3.48; Protein tyrosine phosphatase, non-receptor type 3; Protein-tyrosine phosphatase H1; PTN3; PTPH1; PTP-H1
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
104030
Number AA:
913
UniProt ID:
P26045
International Prot ID:
IPI00289649
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008092
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0051045
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
R
I
N
N
I
R
T
S
E
L
P
K
E
K
T
Site 2
T25
S
E
L
P
K
E
K
T
R
S
E
V
I
C
S
Site 3
S27
L
P
K
E
K
T
R
S
E
V
I
C
S
I
H
Site 4
T42
F
L
D
G
V
V
Q
T
F
K
V
T
K
Q
D
Site 5
Y69
L
G
V
T
E
K
E
Y
F
G
L
Q
H
D
D
Site 6
S78
G
L
Q
H
D
D
D
S
V
D
S
P
R
W
L
Site 7
S81
H
D
D
D
S
V
D
S
P
R
W
L
E
A
S
Site 8
S88
S
P
R
W
L
E
A
S
K
A
I
R
K
Q
L
Site 9
T116
F
F
I
P
D
P
N
T
L
Q
Q
E
Q
T
R
Site 10
Y126
Q
E
Q
T
R
H
L
Y
F
L
Q
L
K
M
D
Site 11
Y161
V
Q
S
H
F
G
D
Y
N
S
S
I
H
H
P
Site 12
Y170
S
S
I
H
H
P
G
Y
L
S
D
S
H
F
I
Site 13
S172
I
H
H
P
G
Y
L
S
D
S
H
F
I
P
D
Site 14
S174
H
P
G
Y
L
S
D
S
H
F
I
P
D
Q
N
Site 15
T186
D
Q
N
E
D
F
L
T
K
V
E
S
L
H
E
Site 16
S190
D
F
L
T
K
V
E
S
L
H
E
Q
H
S
G
Site 17
S196
E
S
L
H
E
Q
H
S
G
L
K
Q
S
E
A
Site 18
S201
Q
H
S
G
L
K
Q
S
E
A
E
S
C
Y
I
Site 19
S205
L
K
Q
S
E
A
E
S
C
Y
I
N
I
A
R
Site 20
Y217
I
A
R
T
L
D
F
Y
G
V
E
L
H
S
G
Site 21
S223
F
Y
G
V
E
L
H
S
G
R
D
L
H
N
L
Site 22
Y291
V
A
F
N
M
L
N
Y
R
S
C
K
N
L
W
Site 23
T306
K
S
C
V
E
H
H
T
F
F
Q
A
K
K
L
Site 24
S322
P
Q
E
K
N
V
L
S
Q
Y
W
T
M
G
S
Site 25
Y324
E
K
N
V
L
S
Q
Y
W
T
M
G
S
R
N
Site 26
T326
N
V
L
S
Q
Y
W
T
M
G
S
R
N
T
K
Site 27
S335
G
S
R
N
T
K
K
S
V
N
N
Q
Y
C
K
Site 28
Y340
K
K
S
V
N
N
Q
Y
C
K
K
V
I
G
G
Site 29
S357
W
N
P
A
M
R
R
S
L
S
V
E
H
L
E
Site 30
S359
P
A
M
R
R
S
L
S
V
E
H
L
E
T
K
Site 31
T365
L
S
V
E
H
L
E
T
K
S
L
P
S
R
S
Site 32
S367
V
E
H
L
E
T
K
S
L
P
S
R
S
P
P
Site 33
S370
T
K
S
L
P
S
R
S
P
P
I
T
P
N
W
Site 34
S372
L
E
T
K
S
L
P
S
R
S
P
P
I
T
P
Site 35
T376
P
S
R
S
P
P
I
T
P
N
W
R
S
P
R
Site 36
S381
P
I
T
P
N
W
R
S
P
R
L
R
H
E
I
Site 37
S394
E
I
R
K
P
R
H
S
S
A
D
N
L
A
N
Site 38
S395
I
R
K
P
R
H
S
S
A
D
N
L
A
N
E
Site 39
T409
E
M
T
Y
I
T
E
T
E
D
V
F
Y
T
Y
Site 40
Y414
T
E
T
E
D
V
F
Y
T
Y
K
G
S
L
A
Site 41
T415
E
T
E
D
V
F
Y
T
Y
K
G
S
L
A
P
Site 42
S419
V
F
Y
T
Y
K
G
S
L
A
P
Q
D
S
D
Site 43
S425
G
S
L
A
P
Q
D
S
D
S
E
V
S
Q
N
Site 44
S427
L
A
P
Q
D
S
D
S
E
V
S
Q
N
R
S
Site 45
S430
Q
D
S
D
S
E
V
S
Q
N
R
S
P
H
Q
Site 46
S434
S
E
V
S
Q
N
R
S
P
H
Q
E
S
L
S
Site 47
S439
N
R
S
P
H
Q
E
S
L
S
E
N
N
P
A
Site 48
S441
S
P
H
Q
E
S
L
S
E
N
N
P
A
Q
S
Site 49
S448
S
E
N
N
P
A
Q
S
Y
L
T
Q
K
S
S
Site 50
Y449
E
N
N
P
A
Q
S
Y
L
T
Q
K
S
S
S
Site 51
T451
N
P
A
Q
S
Y
L
T
Q
K
S
S
S
S
V
Site 52
S454
Q
S
Y
L
T
Q
K
S
S
S
S
V
S
P
S
Site 53
S455
S
Y
L
T
Q
K
S
S
S
S
V
S
P
S
S
Site 54
S456
Y
L
T
Q
K
S
S
S
S
V
S
P
S
S
N
Site 55
S457
L
T
Q
K
S
S
S
S
V
S
P
S
S
N
A
Site 56
S459
Q
K
S
S
S
S
V
S
P
S
S
N
A
P
G
Site 57
S461
S
S
S
S
V
S
P
S
S
N
A
P
G
S
C
Site 58
S462
S
S
S
V
S
P
S
S
N
A
P
G
S
C
S
Site 59
S467
P
S
S
N
A
P
G
S
C
S
P
D
G
V
D
Site 60
S469
S
N
A
P
G
S
C
S
P
D
G
V
D
Q
Q
Site 61
T485
L
D
D
F
H
R
V
T
K
G
G
S
T
E
D
Site 62
T490
R
V
T
K
G
G
S
T
E
D
A
S
Q
Y
Y
Site 63
S494
G
G
S
T
E
D
A
S
Q
Y
Y
C
D
K
N
Site 64
Y496
S
T
E
D
A
S
Q
Y
Y
C
D
K
N
D
N
Site 65
Y507
K
N
D
N
G
D
S
Y
L
V
L
I
R
I
T
Site 66
S544
V
S
R
I
N
P
E
S
P
A
D
T
C
I
P
Site 67
T548
N
P
E
S
P
A
D
T
C
I
P
K
L
N
E
Site 68
S568
L
I
N
G
R
D
I
S
E
H
T
H
D
Q
V
Site 69
S582
V
V
M
F
I
K
A
S
R
E
S
H
S
R
E
Site 70
S585
F
I
K
A
S
R
E
S
H
S
R
E
L
A
L
Site 71
S601
I
R
R
R
A
V
R
S
F
A
D
F
K
S
E
Site 72
S607
R
S
F
A
D
F
K
S
E
D
E
L
N
Q
L
Site 73
T629
M
C
P
E
G
G
D
T
L
E
G
S
M
A
Q
Site 74
S633
G
G
D
T
L
E
G
S
M
A
Q
L
K
K
G
Site 75
Y654
L
I
Q
F
E
Q
L
Y
R
K
K
P
G
L
A
Site 76
T663
K
K
P
G
L
A
I
T
F
A
K
L
P
Q
N
Site 77
Y676
Q
N
L
D
K
N
R
Y
K
D
V
L
P
Y
D
Site 78
T684
K
D
V
L
P
Y
D
T
T
R
V
L
L
Q
G
Site 79
T685
D
V
L
P
Y
D
T
T
R
V
L
L
Q
G
N
Site 80
Y695
L
L
Q
G
N
E
D
Y
I
N
A
S
Y
V
N
Site 81
Y700
E
D
Y
I
N
A
S
Y
V
N
M
E
I
P
A
Site 82
T717
L
V
N
K
Y
I
A
T
Q
G
P
L
P
H
T
Site 83
T752
T
L
T
E
R
G
R
T
K
C
H
Q
Y
W
P
Site 84
Y757
G
R
T
K
C
H
Q
Y
W
P
D
P
P
D
V
Site 85
T780
Q
C
Q
S
E
D
C
T
I
A
Y
V
S
R
E
Site 86
T791
V
S
R
E
M
L
V
T
N
T
Q
T
G
E
E
Site 87
T802
T
G
E
E
H
T
V
T
H
L
Q
Y
V
A
W
Site 88
S818
D
H
G
V
P
D
D
S
S
D
F
L
E
F
V
Site 89
S819
H
G
V
P
D
D
S
S
D
F
L
E
F
V
N
Site 90
Y827
D
F
L
E
F
V
N
Y
V
R
S
L
R
V
D
Site 91
S830
E
F
V
N
Y
V
R
S
L
R
V
D
S
E
P
Site 92
S835
V
R
S
L
R
V
D
S
E
P
V
L
V
H
C
Site 93
Y869
T
E
R
N
L
P
I
Y
P
L
D
I
V
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation