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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE4A
Full Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Alias:
DPDE2; PDE46; Phosphodiesterase 4A, cAMP-specific; Phosphodiesterase E2 dunce
Type:
EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase
Mass (Da):
98143
Number AA:
886
UniProt ID:
P27815
International Prot ID:
IPI00020973
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0004115
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
E
P
P
T
V
P
S
E
R
S
L
Site 2
S8
M
E
P
P
T
V
P
S
E
R
S
L
S
L
S
Site 3
S11
P
T
V
P
S
E
R
S
L
S
L
S
L
P
G
Site 4
S13
V
P
S
E
R
S
L
S
L
S
L
P
G
P
R
Site 5
S15
S
E
R
S
L
S
L
S
L
P
G
P
R
E
G
Site 6
T25
G
P
R
E
G
Q
A
T
L
K
P
P
P
Q
H
Site 7
T39
H
L
W
R
Q
P
R
T
P
I
R
I
Q
Q
R
Site 8
Y48
I
R
I
Q
Q
R
G
Y
S
D
S
A
E
R
A
Site 9
S49
R
I
Q
Q
R
G
Y
S
D
S
A
E
R
A
E
Site 10
S51
Q
Q
R
G
Y
S
D
S
A
E
R
A
E
R
E
Site 11
S74
R
A
D
A
M
D
T
S
D
R
P
G
L
R
T
Site 12
T81
S
D
R
P
G
L
R
T
T
R
M
S
W
P
S
Site 13
T82
D
R
P
G
L
R
T
T
R
M
S
W
P
S
S
Site 14
S85
G
L
R
T
T
R
M
S
W
P
S
S
F
H
G
Site 15
S88
T
T
R
M
S
W
P
S
S
F
H
G
T
G
T
Site 16
S89
T
R
M
S
W
P
S
S
F
H
G
T
G
T
G
Site 17
T93
W
P
S
S
F
H
G
T
G
T
G
S
G
G
A
Site 18
T95
S
S
F
H
G
T
G
T
G
S
G
G
A
G
G
Site 19
S97
F
H
G
T
G
T
G
S
G
G
A
G
G
G
S
Site 20
S104
S
G
G
A
G
G
G
S
S
R
R
F
E
A
E
Site 21
S105
G
G
A
G
G
G
S
S
R
R
F
E
A
E
N
Site 22
T115
F
E
A
E
N
G
P
T
P
S
P
G
R
S
P
Site 23
S117
A
E
N
G
P
T
P
S
P
G
R
S
P
L
D
Site 24
S121
P
T
P
S
P
G
R
S
P
L
D
S
Q
A
S
Site 25
S125
P
G
R
S
P
L
D
S
Q
A
S
P
G
L
V
Site 26
S140
L
H
A
G
A
A
T
S
Q
R
R
E
S
F
L
Site 27
S145
A
T
S
Q
R
R
E
S
F
L
Y
R
S
D
S
Site 28
Y148
Q
R
R
E
S
F
L
Y
R
S
D
S
D
Y
D
Site 29
S150
R
E
S
F
L
Y
R
S
D
S
D
Y
D
M
S
Site 30
S152
S
F
L
Y
R
S
D
S
D
Y
D
M
S
P
K
Site 31
Y154
L
Y
R
S
D
S
D
Y
D
M
S
P
K
T
M
Site 32
S157
S
D
S
D
Y
D
M
S
P
K
T
M
S
R
N
Site 33
T160
D
Y
D
M
S
P
K
T
M
S
R
N
S
S
V
Site 34
S162
D
M
S
P
K
T
M
S
R
N
S
S
V
T
S
Site 35
S165
P
K
T
M
S
R
N
S
S
V
T
S
E
A
H
Site 36
S166
K
T
M
S
R
N
S
S
V
T
S
E
A
H
A
Site 37
S169
S
R
N
S
S
V
T
S
E
A
H
A
E
D
L
Site 38
T179
H
A
E
D
L
I
V
T
P
F
A
Q
V
L
A
Site 39
S187
P
F
A
Q
V
L
A
S
L
R
S
V
R
S
N
Site 40
S193
A
S
L
R
S
V
R
S
N
F
S
L
L
T
N
Site 41
S196
R
S
V
R
S
N
F
S
L
L
T
N
V
P
V
Site 42
T199
R
S
N
F
S
L
L
T
N
V
P
V
P
S
N
Site 43
S205
L
T
N
V
P
V
P
S
N
K
R
S
P
L
G
Site 44
S209
P
V
P
S
N
K
R
S
P
L
G
G
P
T
P
Site 45
T215
R
S
P
L
G
G
P
T
P
V
C
K
A
T
L
Site 46
T221
P
T
P
V
C
K
A
T
L
S
E
E
T
C
Q
Site 47
S223
P
V
C
K
A
T
L
S
E
E
T
C
Q
Q
L
Site 48
T234
C
Q
Q
L
A
R
E
T
L
E
E
L
D
W
C
Site 49
T250
E
Q
L
E
T
M
Q
T
Y
R
S
V
S
E
M
Site 50
Y251
Q
L
E
T
M
Q
T
Y
R
S
V
S
E
M
A
Site 51
S253
E
T
M
Q
T
Y
R
S
V
S
E
M
A
S
H
Site 52
S255
M
Q
T
Y
R
S
V
S
E
M
A
S
H
K
F
Site 53
S259
R
S
V
S
E
M
A
S
H
K
F
K
R
M
L
Site 54
T271
R
M
L
N
R
E
L
T
H
L
S
E
M
S
R
Site 55
S274
N
R
E
L
T
H
L
S
E
M
S
R
S
G
N
Site 56
S279
H
L
S
E
M
S
R
S
G
N
Q
V
S
E
Y
Site 57
S284
S
R
S
G
N
Q
V
S
E
Y
I
S
T
T
F
Site 58
Y286
S
G
N
Q
V
S
E
Y
I
S
T
T
F
L
D
Site 59
S288
N
Q
V
S
E
Y
I
S
T
T
F
L
D
K
Q
Site 60
S302
Q
N
E
V
E
I
P
S
P
T
M
K
E
R
E
Site 61
T304
E
V
E
I
P
S
P
T
M
K
E
R
E
K
Q
Site 62
S319
Q
A
P
R
P
R
P
S
Q
P
P
P
P
P
V
Site 63
S333
V
P
H
L
Q
P
M
S
Q
I
T
G
L
K
K
Site 64
S344
G
L
K
K
L
M
H
S
N
S
L
N
N
S
N
Site 65
S346
K
K
L
M
H
S
N
S
L
N
N
S
N
I
P
Site 66
S350
H
S
N
S
L
N
N
S
N
I
P
R
F
G
V
Site 67
T359
I
P
R
F
G
V
K
T
D
Q
E
E
L
L
A
Site 68
Y396
R
S
L
T
C
I
M
Y
M
I
F
Q
E
R
D
Site 69
T421
T
M
V
T
Y
M
L
T
L
E
D
H
Y
H
A
Site 70
Y426
M
L
T
L
E
D
H
Y
H
A
D
V
A
Y
H
Site 71
Y432
H
Y
H
A
D
V
A
Y
H
N
S
L
H
A
A
Site 72
S526
C
D
I
F
Q
N
L
S
K
R
Q
R
Q
S
L
Site 73
S532
L
S
K
R
Q
R
Q
S
L
R
K
M
V
I
D
Site 74
T551
T
D
M
S
K
H
M
T
L
L
A
D
L
K
T
Site 75
S567
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
Site 76
S568
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Site 77
S577
V
L
L
L
D
N
Y
S
D
R
I
Q
V
L
R
Site 78
S593
M
V
H
C
A
D
L
S
N
P
T
K
P
L
E
Site 79
Y602
P
T
K
P
L
E
L
Y
R
Q
W
T
D
R
I
Site 80
T606
L
E
L
Y
R
Q
W
T
D
R
I
M
A
E
F
Site 81
S628
R
E
R
G
M
E
I
S
P
M
C
D
K
H
T
Site 82
T635
S
P
M
C
D
K
H
T
A
S
V
E
K
S
Q
Site 83
S637
M
C
D
K
H
T
A
S
V
E
K
S
Q
V
G
Site 84
S641
H
T
A
S
V
E
K
S
Q
V
G
F
I
D
Y
Site 85
T671
D
A
Q
E
I
L
D
T
L
E
D
N
R
D
W
Site 86
Y679
L
E
D
N
R
D
W
Y
Y
S
A
I
R
Q
S
Site 87
Y680
E
D
N
R
D
W
Y
Y
S
A
I
R
Q
S
P
Site 88
S681
D
N
R
D
W
Y
Y
S
A
I
R
Q
S
P
S
Site 89
S686
Y
Y
S
A
I
R
Q
S
P
S
P
P
P
E
E
Site 90
S688
S
A
I
R
Q
S
P
S
P
P
P
E
E
E
S
Site 91
S695
S
P
P
P
E
E
E
S
R
G
P
G
H
P
P
Site 92
S722
E
E
E
E
E
E
I
S
M
A
Q
I
P
C
T
Site 93
S755
A
T
I
A
W
E
A
S
P
A
Q
E
S
L
E
Site 94
S769
E
V
M
A
Q
E
A
S
L
E
A
E
L
E
A
Site 95
S797
P
V
A
P
D
E
F
S
S
R
E
E
F
V
V
Site 96
T826
P
L
L
P
A
W
R
T
L
S
V
S
E
H
A
Site 97
S828
L
P
A
W
R
T
L
S
V
S
E
H
A
P
G
Site 98
S830
A
W
R
T
L
S
V
S
E
H
A
P
G
L
P
Site 99
T870
A
G
T
F
G
E
D
T
S
A
L
P
A
P
G
Site 100
S871
G
T
F
G
E
D
T
S
A
L
P
A
P
G
G
Site 101
S881
P
A
P
G
G
G
G
S
G
G
D
P
T
_
_
Site 102
T886
G
G
S
G
G
D
P
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation