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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DKFZp779A1753
Full Name:
Microtubule-associated protein 4
Alias:
Type:
Mass (Da):
Number AA:
492
UniProt ID:
P27816
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005874
GO:0005875
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0007026
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
L
S
L
A
D
A
L
T
E
P
S
P
D
I
E
Site 2
S14
A
D
A
L
T
E
P
S
P
D
I
E
G
E
I
Site 3
T28
I
K
R
D
F
I
A
T
L
E
A
E
A
F
D
Site 4
T41
F
D
D
V
V
G
E
T
V
G
K
T
D
Y
I
Site 5
T45
V
G
E
T
V
G
K
T
D
Y
I
P
L
L
D
Site 6
Y47
E
T
V
G
K
T
D
Y
I
P
L
L
D
V
D
Site 7
T57
L
L
D
V
D
E
K
T
G
N
S
E
S
K
K
Site 8
S60
V
D
E
K
T
G
N
S
E
S
K
K
K
P
C
Site 9
S62
E
K
T
G
N
S
E
S
K
K
K
P
C
S
E
Site 10
S68
E
S
K
K
K
P
C
S
E
T
S
Q
I
E
D
Site 11
T70
K
K
K
P
C
S
E
T
S
Q
I
E
D
T
P
Site 12
S71
K
K
P
C
S
E
T
S
Q
I
E
D
T
P
S
Site 13
T76
E
T
S
Q
I
E
D
T
P
S
S
K
P
T
L
Site 14
S78
S
Q
I
E
D
T
P
S
S
K
P
T
L
L
A
Site 15
S79
Q
I
E
D
T
P
S
S
K
P
T
L
L
A
N
Site 16
T82
D
T
P
S
S
K
P
T
L
L
A
N
G
G
H
Site 17
S94
G
G
H
G
V
E
G
S
D
T
T
G
S
P
T
Site 18
T96
H
G
V
E
G
S
D
T
T
G
S
P
T
E
F
Site 19
T97
G
V
E
G
S
D
T
T
G
S
P
T
E
F
L
Site 20
S99
E
G
S
D
T
T
G
S
P
T
E
F
L
E
E
Site 21
T101
S
D
T
T
G
S
P
T
E
F
L
E
E
K
M
Site 22
Y110
F
L
E
E
K
M
A
Y
Q
E
Y
P
N
S
Q
Site 23
Y113
E
K
M
A
Y
Q
E
Y
P
N
S
Q
N
W
P
Site 24
Y144
Q
T
D
P
F
K
M
Y
H
D
D
D
L
A
D
Site 25
S163
S
S
A
T
A
D
T
S
I
F
A
G
Q
N
D
Site 26
S175
Q
N
D
P
L
K
D
S
Y
G
M
S
P
C
N
Site 27
Y176
N
D
P
L
K
D
S
Y
G
M
S
P
C
N
T
Site 28
S179
L
K
D
S
Y
G
M
S
P
C
N
T
A
V
V
Site 29
S191
A
V
V
P
Q
G
W
S
V
E
A
L
N
S
P
Site 30
S197
W
S
V
E
A
L
N
S
P
H
S
E
S
F
V
Site 31
S200
E
A
L
N
S
P
H
S
E
S
F
V
S
P
E
Site 32
S202
L
N
S
P
H
S
E
S
F
V
S
P
E
A
V
Site 33
S205
P
H
S
E
S
F
V
S
P
E
A
V
A
E
P
Site 34
T216
V
A
E
P
P
Q
P
T
A
V
P
L
E
L
A
Site 35
S230
A
K
E
I
E
M
A
S
E
E
R
P
P
A
Q
Site 36
T247
E
I
M
M
G
L
K
T
T
D
M
A
P
S
K
Site 37
S253
K
T
T
D
M
A
P
S
K
E
T
E
M
A
L
Site 38
T256
D
M
A
P
S
K
E
T
E
M
A
L
A
K
D
Site 39
S280
A
L
A
K
D
M
E
S
P
T
K
L
D
V
T
Site 40
T282
A
K
D
M
E
S
P
T
K
L
D
V
T
L
A
Site 41
T287
S
P
T
K
L
D
V
T
L
A
K
D
M
Q
P
Site 42
S295
L
A
K
D
M
Q
P
S
M
E
S
D
M
A
L
Site 43
T324
V
K
D
V
R
W
P
T
E
T
D
V
S
S
A
Site 44
T326
D
V
R
W
P
T
E
T
D
V
S
S
A
K
N
Site 45
S329
W
P
T
E
T
D
V
S
S
A
K
N
V
V
L
Site 46
T340
N
V
V
L
P
T
E
T
E
V
A
P
A
K
D
Site 47
T349
V
A
P
A
K
D
V
T
L
L
K
E
T
E
R
Site 48
T354
D
V
T
L
L
K
E
T
E
R
A
S
P
I
K
Site 49
S358
L
K
E
T
E
R
A
S
P
I
K
M
D
L
A
Site 50
S367
I
K
M
D
L
A
P
S
K
D
M
G
P
P
K
Site 51
T380
P
K
E
N
K
K
E
T
E
R
A
S
P
I
K
Site 52
S384
K
K
E
T
E
R
A
S
P
I
K
M
D
L
A
Site 53
S414
A
K
D
L
V
L
L
S
E
I
E
V
A
Q
A
Site 54
S426
A
Q
A
N
D
I
I
S
S
T
E
I
S
S
A
Site 55
S427
Q
A
N
D
I
I
S
S
T
E
I
S
S
A
E
Site 56
T428
A
N
D
I
I
S
S
T
E
I
S
S
A
E
K
Site 57
S431
I
I
S
S
T
E
I
S
S
A
E
K
V
A
L
Site 58
S440
A
E
K
V
A
L
S
S
E
T
E
V
A
L
A
Site 59
T442
K
V
A
L
S
S
E
T
E
V
A
L
A
R
D
Site 60
T451
V
A
L
A
R
D
M
T
L
P
P
E
T
N
V
Site 61
T484
D
M
A
Q
L
P
E
T
E
I
A
P
A
K
D
Site 62
S495
P
A
K
D
V
A
P
S
T
V
K
E
V
G
L
Site 63
T496
A
K
D
V
A
P
S
T
V
K
E
V
G
L
L
Site 64
S507
V
G
L
L
K
D
M
S
P
L
S
E
T
E
M
Site 65
S510
L
K
D
M
S
P
L
S
E
T
E
M
A
L
G
Site 66
T512
D
M
S
P
L
S
E
T
E
M
A
L
G
K
D
Site 67
T521
M
A
L
G
K
D
V
T
P
P
P
E
T
E
V
Site 68
T526
D
V
T
P
P
P
E
T
E
V
V
L
I
K
N
Site 69
T545
P
E
M
E
V
A
L
T
E
D
Q
V
P
A
L
Site 70
T554
D
Q
V
P
A
L
K
T
E
A
P
L
A
K
D
Site 71
T565
L
A
K
D
G
V
L
T
L
A
N
N
V
T
P
Site 72
T571
L
T
L
A
N
N
V
T
P
A
K
D
V
P
P
Site 73
S580
A
K
D
V
P
P
L
S
E
T
E
A
T
P
V
Site 74
T582
D
V
P
P
L
S
E
T
E
A
T
P
V
P
I
Site 75
T585
P
L
S
E
T
E
A
T
P
V
P
I
K
D
M
Site 76
T597
K
D
M
E
I
A
Q
T
Q
K
G
I
S
E
D
Site 77
S602
A
Q
T
Q
K
G
I
S
E
D
S
H
L
E
S
Site 78
S605
Q
K
G
I
S
E
D
S
H
L
E
S
L
Q
D
Site 79
S609
S
E
D
S
H
L
E
S
L
Q
D
V
G
Q
S
Site 80
T620
V
G
Q
S
A
A
P
T
F
M
I
S
P
E
T
Site 81
S624
A
A
P
T
F
M
I
S
P
E
T
I
T
G
T
Site 82
T627
T
F
M
I
S
P
E
T
I
T
G
T
G
K
K
Site 83
T629
M
I
S
P
E
T
I
T
G
T
G
K
K
C
S
Site 84
T631
S
P
E
T
I
T
G
T
G
K
K
C
S
L
P
Site 85
S636
T
G
T
G
K
K
C
S
L
P
A
E
E
D
S
Site 86
S643
S
L
P
A
E
E
D
S
V
L
E
K
L
G
E
Site 87
S656
G
E
R
K
P
C
N
S
Q
P
S
E
L
S
S
Site 88
S659
K
P
C
N
S
Q
P
S
E
L
S
S
E
T
S
Site 89
S662
N
S
Q
P
S
E
L
S
S
E
T
S
G
I
A
Site 90
S663
S
Q
P
S
E
L
S
S
E
T
S
G
I
A
R
Site 91
S666
S
E
L
S
S
E
T
S
G
I
A
R
P
E
E
Site 92
T681
G
R
P
V
V
S
G
T
G
N
D
I
T
T
P
Site 93
T686
S
G
T
G
N
D
I
T
T
P
P
N
K
E
L
Site 94
T687
G
T
G
N
D
I
T
T
P
P
N
K
E
L
P
Site 95
S696
P
N
K
E
L
P
P
S
P
E
K
K
T
K
P
Site 96
T706
K
K
T
K
P
L
A
T
T
Q
P
A
K
T
S
Site 97
T712
A
T
T
Q
P
A
K
T
S
T
S
K
A
K
T
Site 98
T714
T
Q
P
A
K
T
S
T
S
K
A
K
T
Q
P
Site 99
T719
T
S
T
S
K
A
K
T
Q
P
T
S
L
P
K
Site 100
T722
S
K
A
K
T
Q
P
T
S
L
P
K
Q
P
A
Site 101
S723
K
A
K
T
Q
P
T
S
L
P
K
Q
P
A
P
Site 102
S745
K
K
P
M
S
L
A
S
G
L
V
P
A
A
P
Site 103
S760
P
K
R
P
A
V
A
S
A
R
P
S
I
L
P
Site 104
S764
A
V
A
S
A
R
P
S
I
L
P
S
K
D
V
Site 105
S768
A
R
P
S
I
L
P
S
K
D
V
K
P
K
P
Site 106
S787
K
A
P
E
K
R
A
S
P
S
K
P
A
S
A
Site 107
S789
P
E
K
R
A
S
P
S
K
P
A
S
A
P
A
Site 108
S793
A
S
P
S
K
P
A
S
A
P
A
S
R
S
G
Site 109
S797
K
P
A
S
A
P
A
S
R
S
G
S
K
S
T
Site 110
S799
A
S
A
P
A
S
R
S
G
S
K
S
T
Q
T
Site 111
S801
A
P
A
S
R
S
G
S
K
S
T
Q
T
V
A
Site 112
S803
A
S
R
S
G
S
K
S
T
Q
T
V
A
K
T
Site 113
T804
S
R
S
G
S
K
S
T
Q
T
V
A
K
T
T
Site 114
T806
S
G
S
K
S
T
Q
T
V
A
K
T
T
T
A
Site 115
T810
S
T
Q
T
V
A
K
T
T
T
A
A
A
V
A
Site 116
T811
T
Q
T
V
A
K
T
T
T
A
A
A
V
A
S
Site 117
T812
Q
T
V
A
K
T
T
T
A
A
A
V
A
S
T
Site 118
S818
T
T
A
A
A
V
A
S
T
G
P
S
S
R
S
Site 119
S822
A
V
A
S
T
G
P
S
S
R
S
P
S
T
L
Site 120
S823
V
A
S
T
G
P
S
S
R
S
P
S
T
L
L
Site 121
S825
S
T
G
P
S
S
R
S
P
S
T
L
L
P
K
Site 122
S827
G
P
S
S
R
S
P
S
T
L
L
P
K
K
P
Site 123
T828
P
S
S
R
S
P
S
T
L
L
P
K
K
P
T
Site 124
S853
V
K
K
M
T
A
K
S
V
P
A
D
L
S
R
Site 125
S859
K
S
V
P
A
D
L
S
R
P
K
S
T
S
T
Site 126
S863
A
D
L
S
R
P
K
S
T
S
T
S
S
M
K
Site 127
S865
L
S
R
P
K
S
T
S
T
S
S
M
K
K
T
Site 128
S867
R
P
K
S
T
S
T
S
S
M
K
K
T
T
T
Site 129
S868
P
K
S
T
S
T
S
S
M
K
K
T
T
T
L
Site 130
T872
S
T
S
S
M
K
K
T
T
T
L
S
G
T
A
Site 131
T873
T
S
S
M
K
K
T
T
T
L
S
G
T
A
P
Site 132
T874
S
S
M
K
K
T
T
T
L
S
G
T
A
P
A
Site 133
S876
M
K
K
T
T
T
L
S
G
T
A
P
A
A
G
Site 134
T878
K
T
T
T
L
S
G
T
A
P
A
A
G
V
V
Site 135
T892
V
P
S
R
V
K
A
T
P
M
P
S
R
P
S
Site 136
S896
V
K
A
T
P
M
P
S
R
P
S
T
T
P
F
Site 137
S899
T
P
M
P
S
R
P
S
T
T
P
F
I
D
K
Site 138
T900
P
M
P
S
R
P
S
T
T
P
F
I
D
K
K
Site 139
T901
M
P
S
R
P
S
T
T
P
F
I
D
K
K
P
Site 140
S910
F
I
D
K
K
P
T
S
A
K
P
S
S
T
T
Site 141
S914
K
P
T
S
A
K
P
S
S
T
T
P
R
L
S
Site 142
S915
P
T
S
A
K
P
S
S
T
T
P
R
L
S
R
Site 143
T916
T
S
A
K
P
S
S
T
T
P
R
L
S
R
L
Site 144
T917
S
A
K
P
S
S
T
T
P
R
L
S
R
L
A
Site 145
S921
S
S
T
T
P
R
L
S
R
L
A
T
N
T
S
Site 146
T925
P
R
L
S
R
L
A
T
N
T
S
A
P
D
L
Site 147
T927
L
S
R
L
A
T
N
T
S
A
P
D
L
K
N
Site 148
S928
S
R
L
A
T
N
T
S
A
P
D
L
K
N
V
Site 149
S937
P
D
L
K
N
V
R
S
K
V
G
S
T
E
N
Site 150
S941
N
V
R
S
K
V
G
S
T
E
N
I
K
H
Q
Site 151
T942
V
R
S
K
V
G
S
T
E
N
I
K
H
Q
P
Site 152
T960
R
A
K
V
E
K
K
T
E
A
A
A
T
T
R
Site 153
T965
K
K
T
E
A
A
A
T
T
R
K
P
E
S
N
Site 154
S971
A
T
T
R
K
P
E
S
N
A
V
T
K
T
A
Site 155
T975
K
P
E
S
N
A
V
T
K
T
A
G
P
I
A
Site 156
T977
E
S
N
A
V
T
K
T
A
G
P
I
A
S
A
Site 157
S983
K
T
A
G
P
I
A
S
A
Q
K
Q
P
A
G
Site 158
S996
A
G
K
V
Q
I
V
S
K
K
V
S
Y
S
H
Site 159
S1000
Q
I
V
S
K
K
V
S
Y
S
H
I
Q
S
K
Site 160
Y1001
I
V
S
K
K
V
S
Y
S
H
I
Q
S
K
C
Site 161
S1002
V
S
K
K
V
S
Y
S
H
I
Q
S
K
C
G
Site 162
S1006
V
S
Y
S
H
I
Q
S
K
C
G
S
K
D
N
Site 163
S1033
Q
N
K
K
V
D
I
S
K
V
S
S
K
C
G
Site 164
S1036
K
V
D
I
S
K
V
S
S
K
C
G
S
K
A
Site 165
S1037
V
D
I
S
K
V
S
S
K
C
G
S
K
A
N
Site 166
S1041
K
V
S
S
K
C
G
S
K
A
N
I
K
H
K
Site 167
S1058
G
G
D
V
K
I
E
S
Q
K
L
N
F
K
E
Site 168
S1073
K
A
Q
A
K
V
G
S
L
D
N
V
G
H
L
Site 169
T1088
P
A
G
G
A
V
K
T
E
G
G
G
S
E
A
Site 170
S1093
V
K
T
E
G
G
G
S
E
A
P
L
C
P
G
Site 171
S1110
A
G
E
E
P
A
I
S
E
A
A
P
E
A
G
Site 172
S1121
P
E
A
G
A
P
T
S
A
S
G
L
N
G
H
Site 173
S1123
A
G
A
P
T
S
A
S
G
L
N
G
H
P
T
Site 174
T1130
S
G
L
N
G
H
P
T
L
S
G
G
G
D
Q
Site 175
S1132
L
N
G
H
P
T
L
S
G
G
G
D
Q
R
E
Site 176
S1145
R
E
A
Q
T
L
D
S
Q
I
Q
E
T
S
I
Site 177
T1150
L
D
S
Q
I
Q
E
T
S
I
_
_
_
_
_
Site 178
S1151
D
S
Q
I
Q
E
T
S
I
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation