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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN6
Full Name:
Tyrosine-protein phosphatase non-receptor type 6
Alias:
70Z-SHP; EC 3.1.3.48; HCP; HCPH; PTN6; PTP1C; SH-PTP1
Type:
Protein-tyrosine phosphatase
Mass (Da):
67561
Number AA:
595
UniProt ID:
P29350
International Prot ID:
IPI00218604
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016020
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0006915
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
W
F
H
R
D
L
S
G
L
D
A
E
T
L
Site 2
S26
K
G
R
G
V
H
G
S
F
L
A
R
P
S
R
Site 3
S32
G
S
F
L
A
R
P
S
R
K
N
Q
G
D
F
Site 4
S40
R
K
N
Q
G
D
F
S
L
S
V
R
V
G
D
Site 5
S42
N
Q
G
D
F
S
L
S
V
R
V
G
D
Q
V
Site 6
T50
V
R
V
G
D
Q
V
T
H
I
R
I
Q
N
S
Site 7
S57
T
H
I
R
I
Q
N
S
G
D
F
Y
D
L
Y
Site 8
Y61
I
Q
N
S
G
D
F
Y
D
L
Y
G
G
E
K
Site 9
Y64
S
G
D
F
Y
D
L
Y
G
G
E
K
F
A
T
Site 10
T71
Y
G
G
E
K
F
A
T
L
T
E
L
V
E
Y
Site 11
T73
G
E
K
F
A
T
L
T
E
L
V
E
Y
Y
T
Site 12
Y78
T
L
T
E
L
V
E
Y
Y
T
Q
Q
Q
G
V
Site 13
Y79
L
T
E
L
V
E
Y
Y
T
Q
Q
Q
G
V
L
Site 14
T92
V
L
Q
D
R
D
G
T
I
I
H
L
K
Y
P
Site 15
Y98
G
T
I
I
H
L
K
Y
P
L
N
C
S
D
P
Site 16
S103
L
K
Y
P
L
N
C
S
D
P
T
S
E
R
W
Site 17
T106
P
L
N
C
S
D
P
T
S
E
R
W
Y
H
G
Site 18
Y111
D
P
T
S
E
R
W
Y
H
G
H
M
S
G
G
Site 19
T132
Q
A
K
G
E
P
W
T
F
L
V
R
E
S
L
Site 20
S138
W
T
F
L
V
R
E
S
L
S
Q
P
G
D
F
Site 21
S148
Q
P
G
D
F
V
L
S
V
L
S
D
Q
P
K
Site 22
S151
D
F
V
L
S
V
L
S
D
Q
P
K
A
G
P
Site 23
S160
Q
P
K
A
G
P
G
S
P
L
R
V
T
H
I
Site 24
T165
P
G
S
P
L
R
V
T
H
I
K
V
M
C
E
Site 25
T177
M
C
E
G
G
R
Y
T
V
G
G
L
E
T
F
Site 26
S186
G
G
L
E
T
F
D
S
L
T
D
L
V
E
H
Site 27
T188
L
E
T
F
D
S
L
T
D
L
V
E
H
F
K
Site 28
S203
K
T
G
I
E
E
A
S
G
A
F
V
Y
L
R
Site 29
Y208
E
A
S
G
A
F
V
Y
L
R
Q
P
Y
Y
A
Site 30
Y213
F
V
Y
L
R
Q
P
Y
Y
A
T
R
V
N
A
Site 31
Y214
V
Y
L
R
Q
P
Y
Y
A
T
R
V
N
A
A
Site 32
T239
K
K
Q
E
S
E
D
T
A
K
A
G
F
W
E
Site 33
S250
G
F
W
E
E
F
E
S
L
Q
K
Q
E
V
K
Site 34
Y276
E
N
K
G
K
N
R
Y
K
N
I
L
P
F
D
Site 35
S285
N
I
L
P
F
D
H
S
R
V
I
L
Q
G
R
Site 36
S294
V
I
L
Q
G
R
D
S
N
I
P
G
S
D
Y
Site 37
S299
R
D
S
N
I
P
G
S
D
Y
I
N
A
N
Y
Site 38
Y301
S
N
I
P
G
S
D
Y
I
N
A
N
Y
I
K
Site 39
Y306
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
Site 40
T320
G
P
D
E
N
A
K
T
Y
I
A
S
Q
G
C
Site 41
Y321
P
D
E
N
A
K
T
Y
I
A
S
Q
G
C
L
Site 42
T350
N
S
R
V
I
V
M
T
T
R
E
V
E
K
G
Site 43
Y364
G
R
N
K
C
V
P
Y
W
P
E
V
G
M
Q
Site 44
Y374
E
V
G
M
Q
R
A
Y
G
P
Y
S
V
T
N
Site 45
Y377
M
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
Site 46
S378
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
H
Site 47
T387
T
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
Site 48
T388
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
L
Site 49
Y390
G
E
H
D
T
T
E
Y
K
L
R
T
L
Q
V
Site 50
T394
T
T
E
Y
K
L
R
T
L
Q
V
S
P
L
D
Site 51
S398
K
L
R
T
L
Q
V
S
P
L
D
N
G
D
L
Site 52
S424
W
P
D
H
G
V
P
S
E
P
G
G
V
L
S
Site 53
S431
S
E
P
G
G
V
L
S
F
L
D
Q
I
N
Q
Site 54
S442
Q
I
N
Q
R
Q
E
S
L
P
H
A
G
P
I
Site 55
S496
Q
M
V
R
A
Q
R
S
G
M
V
Q
T
E
A
Site 56
Y505
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
Site 57
Y509
E
A
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
Site 58
S528
K
K
L
E
V
L
Q
S
Q
K
G
Q
E
S
E
Site 59
S534
Q
S
Q
K
G
Q
E
S
E
Y
G
N
I
T
Y
Site 60
Y536
Q
K
G
Q
E
S
E
Y
G
N
I
T
Y
P
P
Site 61
T540
E
S
E
Y
G
N
I
T
Y
P
P
A
M
K
N
Site 62
Y541
S
E
Y
G
N
I
T
Y
P
P
A
M
K
N
A
Site 63
S553
K
N
A
H
A
K
A
S
R
T
S
S
K
H
K
Site 64
T555
A
H
A
K
A
S
R
T
S
S
K
H
K
E
D
Site 65
S556
H
A
K
A
S
R
T
S
S
K
H
K
E
D
V
Site 66
S557
A
K
A
S
R
T
S
S
K
H
K
E
D
V
Y
Site 67
Y564
S
K
H
K
E
D
V
Y
E
N
L
H
T
K
N
Site 68
T569
D
V
Y
E
N
L
H
T
K
N
K
R
E
E
K
Site 69
S582
E
K
V
K
K
Q
R
S
A
D
K
E
K
S
K
Site 70
S588
R
S
A
D
K
E
K
S
K
G
S
L
K
R
K
Site 71
S591
D
K
E
K
S
K
G
S
L
K
R
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation