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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDIA3
Full Name:
Protein disulfide-isomerase A3
Alias:
Disulfide isomerase ER-60; ERp57; ERp60; PDA3
Type:
Enzyme, disulphide isomerase
Mass (Da):
56782
Number AA:
505
UniProt ID:
P30101
International Prot ID:
IPI00025252
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005788
GO:0016023
Uniprot
OncoNet
Molecular Function:
GO:0003756
GO:0003824
GO:0004175
PhosphoSite+
KinaseNET
Biological Process:
GO:0006605
GO:0006606
GO:0006621
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein disulfide-isomerase A3 pan-specific antibody AB-NN040-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN040-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
A
S
D
V
L
E
L
T
D
D
N
F
E
S
R
Site 2
S37
L
T
D
D
N
F
E
S
R
I
S
D
T
G
S
Site 3
S40
D
N
F
E
S
R
I
S
D
T
G
S
A
G
L
Site 4
Y67
C
K
R
L
A
P
E
Y
E
A
A
A
T
R
L
Site 5
T72
P
E
Y
E
A
A
A
T
R
L
K
G
I
V
P
Site 6
Y95
N
T
N
T
C
N
K
Y
G
V
S
G
Y
P
T
Site 7
Y100
N
K
Y
G
V
S
G
Y
P
T
L
K
I
F
R
Site 8
T102
Y
G
V
S
G
Y
P
T
L
K
I
F
R
D
G
Site 9
Y115
D
G
E
E
A
G
A
Y
D
G
P
R
T
A
D
Site 10
T120
G
A
Y
D
G
P
R
T
A
D
G
I
V
S
H
Site 11
S126
R
T
A
D
G
I
V
S
H
L
K
K
Q
A
G
Site 12
S136
K
K
Q
A
G
P
A
S
V
P
L
R
T
E
E
Site 13
T141
P
A
S
V
P
L
R
T
E
E
E
F
K
K
F
Site 14
S150
E
E
F
K
K
F
I
S
D
K
D
A
S
I
V
Site 15
S163
I
V
G
F
F
D
D
S
F
S
E
A
H
S
E
Site 16
S165
G
F
F
D
D
S
F
S
E
A
H
S
E
F
L
Site 17
S169
D
S
F
S
E
A
H
S
E
F
L
K
A
A
S
Site 18
Y182
A
S
N
L
R
D
N
Y
R
F
A
H
T
N
V
Site 19
Y196
V
E
S
L
V
N
E
Y
D
D
N
G
E
G
I
Site 20
S209
G
I
I
L
F
R
P
S
H
L
T
N
K
F
E
Site 21
T212
L
F
R
P
S
H
L
T
N
K
F
E
D
K
T
Site 22
T219
T
N
K
F
E
D
K
T
V
A
Y
T
E
Q
K
Site 23
T223
E
D
K
T
V
A
Y
T
E
Q
K
M
T
S
G
Site 24
Y264
G
K
D
L
L
I
A
Y
Y
D
V
D
Y
E
K
Site 25
Y265
K
D
L
L
I
A
Y
Y
D
V
D
Y
E
K
N
Site 26
Y269
I
A
Y
Y
D
V
D
Y
E
K
N
A
K
G
S
Site 27
Y278
K
N
A
K
G
S
N
Y
W
R
N
R
V
M
M
Site 28
S303
K
L
N
F
A
V
A
S
R
K
T
F
S
H
E
Site 29
T306
F
A
V
A
S
R
K
T
F
S
H
E
L
S
D
Site 30
S308
V
A
S
R
K
T
F
S
H
E
L
S
D
F
G
Site 31
S312
K
T
F
S
H
E
L
S
D
F
G
L
E
S
T
Site 32
S343
F
V
M
Q
E
E
F
S
R
D
G
K
A
L
E
Site 33
Y356
L
E
R
F
L
Q
D
Y
F
D
G
N
L
K
R
Site 34
Y364
F
D
G
N
L
K
R
Y
L
K
S
E
P
I
P
Site 35
S367
N
L
K
R
Y
L
K
S
E
P
I
P
E
S
N
Site 36
S373
K
S
E
P
I
P
E
S
N
D
G
P
V
K
V
Site 37
Y402
K
D
V
L
I
E
F
Y
A
P
W
C
G
H
C
Site 38
Y416
C
K
N
L
E
P
K
Y
K
E
L
G
E
K
L
Site 39
S424
K
E
L
G
E
K
L
S
K
D
P
N
I
V
I
Site 40
T437
V
I
A
K
M
D
A
T
A
N
D
V
P
S
P
Site 41
S443
A
T
A
N
D
V
P
S
P
Y
E
V
R
G
F
Site 42
Y445
A
N
D
V
P
S
P
Y
E
V
R
G
F
P
T
Site 43
T452
Y
E
V
R
G
F
P
T
I
Y
F
S
P
A
N
Site 44
Y454
V
R
G
F
P
T
I
Y
F
S
P
A
N
K
K
Site 45
S456
G
F
P
T
I
Y
F
S
P
A
N
K
K
L
N
Site 46
Y467
K
K
L
N
P
K
K
Y
E
G
G
R
E
L
S
Site 47
S474
Y
E
G
G
R
E
L
S
D
F
I
S
Y
L
Q
Site 48
S478
R
E
L
S
D
F
I
S
Y
L
Q
R
E
A
T
Site 49
Y479
E
L
S
D
F
I
S
Y
L
Q
R
E
A
T
N
Site 50
T485
S
Y
L
Q
R
E
A
T
N
P
P
V
I
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation