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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Wee1
Full Name:
Wee1-like protein kinase
Alias:
EC 2.7.10.2; Kinase WEE1; WEE1; WEE1A; WEE1hu
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.10.2; Other group; WEE family
Mass (Da):
71597
Number AA:
646
UniProt ID:
P30291
International Prot ID:
IPI00025830
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004715
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Wee1 protein-tyrosine kinase S642 phosphosite-specific antibody AB-PK854#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK854#Wee1 protein-tyrosine kinase (L361-P388, human) peptide - Powder PE-01AQR90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AQR90#Wee1 protein-tyrosine kinase (R639-I645, human) pS642 phosphopeptide - Powder PE-04AQN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQN99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
L
R
Q
K
L
I
F
S
P
C
S
D
C
E
E
Site 2
S31
K
L
I
F
S
P
C
S
D
C
E
E
E
E
E
Site 3
S45
E
E
E
E
E
E
G
S
G
H
S
T
G
E
D
Site 4
S48
E
E
E
G
S
G
H
S
T
G
E
D
S
A
F
Site 5
T49
E
E
G
S
G
H
S
T
G
E
D
S
A
F
Q
Site 6
S53
G
H
S
T
G
E
D
S
A
F
Q
E
P
D
S
Site 7
S60
S
A
F
Q
E
P
D
S
P
L
P
P
A
R
S
Site 8
S67
S
P
L
P
P
A
R
S
P
T
E
P
G
P
E
Site 9
T69
L
P
P
A
R
S
P
T
E
P
G
P
E
R
R
Site 10
S78
P
G
P
E
R
R
R
S
P
G
P
A
P
G
S
Site 11
S85
S
P
G
P
A
P
G
S
P
G
E
L
E
E
D
Site 12
S113
G
G
G
A
E
G
D
S
W
E
E
E
G
F
G
Site 13
S121
W
E
E
E
G
F
G
S
S
S
P
V
K
S
P
Site 14
S122
E
E
E
G
F
G
S
S
S
P
V
K
S
P
A
Site 15
S123
E
E
G
F
G
S
S
S
P
V
K
S
P
A
A
Site 16
S127
G
S
S
S
P
V
K
S
P
A
A
P
Y
F
L
Site 17
Y132
V
K
S
P
A
A
P
Y
F
L
G
S
S
F
S
Site 18
S136
A
A
P
Y
F
L
G
S
S
F
S
P
V
R
C
Site 19
S137
A
P
Y
F
L
G
S
S
F
S
P
V
R
C
G
Site 20
S139
Y
F
L
G
S
S
F
S
P
V
R
C
G
G
P
Site 21
S150
C
G
G
P
G
D
A
S
P
R
G
C
G
A
R
Site 22
S165
R
A
G
E
G
R
R
S
P
R
P
D
H
P
G
Site 23
T173
P
R
P
D
H
P
G
T
P
P
H
K
T
F
R
Site 24
T178
P
G
T
P
P
H
K
T
F
R
K
L
R
L
F
Site 25
T187
R
K
L
R
L
F
D
T
P
H
T
P
K
S
L
Site 26
T190
R
L
F
D
T
P
H
T
P
K
S
L
L
S
K
Site 27
S193
D
T
P
H
T
P
K
S
L
L
S
K
A
R
G
Site 28
S196
H
T
P
K
S
L
L
S
K
A
R
G
I
D
S
Site 29
S203
S
K
A
R
G
I
D
S
S
S
V
K
L
R
G
Site 30
S204
K
A
R
G
I
D
S
S
S
V
K
L
R
G
S
Site 31
S205
A
R
G
I
D
S
S
S
V
K
L
R
G
S
S
Site 32
S211
S
S
V
K
L
R
G
S
S
L
F
M
D
T
E
Site 33
S212
S
V
K
L
R
G
S
S
L
F
M
D
T
E
K
Site 34
T217
G
S
S
L
F
M
D
T
E
K
S
G
K
R
E
Site 35
S220
L
F
M
D
T
E
K
S
G
K
R
E
F
D
V
Site 36
T230
R
E
F
D
V
R
Q
T
P
Q
V
N
I
N
P
Site 37
T239
Q
V
N
I
N
P
F
T
P
D
S
L
L
L
H
Site 38
S242
I
N
P
F
T
P
D
S
L
L
L
H
S
S
G
Site 39
S248
D
S
L
L
L
H
S
S
G
Q
C
R
R
R
K
Site 40
Y258
C
R
R
R
K
R
T
Y
W
N
D
S
C
G
E
Site 41
Y272
E
D
M
E
A
S
D
Y
E
L
E
D
E
T
R
Site 42
T285
T
R
P
A
K
R
I
T
I
T
E
S
N
M
K
Site 43
S289
K
R
I
T
I
T
E
S
N
M
K
S
R
Y
T
Site 44
S293
I
T
E
S
N
M
K
S
R
Y
T
T
E
F
H
Site 45
Y295
E
S
N
M
K
S
R
Y
T
T
E
F
H
E
L
Site 46
T296
S
N
M
K
S
R
Y
T
T
E
F
H
E
L
E
Site 47
T297
N
M
K
S
R
Y
T
T
E
F
H
E
L
E
K
Site 48
S307
H
E
L
E
K
I
G
S
G
E
F
G
S
V
F
Site 49
S312
I
G
S
G
E
F
G
S
V
F
K
C
V
K
R
Site 50
Y325
K
R
L
D
G
C
I
Y
A
I
K
R
S
K
K
Site 51
Y348
Q
N
A
L
R
E
V
Y
A
H
A
V
L
G
Q
Site 52
Y362
Q
H
S
H
V
V
R
Y
F
S
A
W
A
E
D
Site 53
Y378
H
M
L
I
Q
N
E
Y
C
N
G
G
S
L
A
Site 54
S383
N
E
Y
C
N
G
G
S
L
A
D
A
I
S
E
Site 55
S389
G
S
L
A
D
A
I
S
E
N
Y
R
I
M
S
Site 56
S396
S
E
N
Y
R
I
M
S
Y
F
K
E
A
E
L
Site 57
Y397
E
N
Y
R
I
M
S
Y
F
K
E
A
E
L
K
Site 58
S419
R
G
L
R
Y
I
H
S
M
S
L
V
H
M
D
Site 59
S435
K
P
S
N
I
F
I
S
R
T
S
I
P
N
A
Site 60
S438
N
I
F
I
S
R
T
S
I
P
N
A
A
S
E
Site 61
T468
I
G
D
L
G
H
V
T
R
I
S
S
P
Q
V
Site 62
S471
L
G
H
V
T
R
I
S
S
P
Q
V
E
E
G
Site 63
S472
G
H
V
T
R
I
S
S
P
Q
V
E
E
G
D
Site 64
S480
P
Q
V
E
E
G
D
S
R
F
L
A
N
E
V
Site 65
T493
E
V
L
Q
E
N
Y
T
H
L
P
K
A
D
I
Site 66
S539
P
R
I
P
Q
V
L
S
Q
E
F
T
E
L
L
Site 67
S559
P
D
P
E
R
R
P
S
A
M
A
L
V
K
H
Site 68
S571
V
K
H
S
V
L
L
S
A
S
R
K
S
A
E
Site 69
S576
L
L
S
A
S
R
K
S
A
E
Q
L
R
I
E
Site 70
T620
L
F
T
D
R
M
A
T
R
S
T
T
Q
S
N
Site 71
S622
T
D
R
M
A
T
R
S
T
T
Q
S
N
R
T
Site 72
T623
D
R
M
A
T
R
S
T
T
Q
S
N
R
T
S
Site 73
T624
R
M
A
T
R
S
T
T
Q
S
N
R
T
S
R
Site 74
S626
A
T
R
S
T
T
Q
S
N
R
T
S
R
L
I
Site 75
S630
T
T
Q
S
N
R
T
S
R
L
I
G
K
K
M
Site 76
S640
I
G
K
K
M
N
R
S
V
S
L
T
I
Y
_
Site 77
S642
K
K
M
N
R
S
V
S
L
T
I
Y
_
_
_
Wee1 protein-tyrosine kinase S642 phosphosite-specific antibody AB-PK854#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK854#Wee1 protein-tyrosine kinase (R639-I645, human) pS642 phosphopeptide - Powder PE-04AQN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQN99
Site 78
Y646
R
S
V
S
L
T
I
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation