KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Cdc25B
Full Name:
M-phase inducer phosphatase 2
Alias:
CDC25HU2; CDC25M2; Cell division cycle 25 B; EC 3.1.3.48; M-phase inducer phosphatase 2; MPIP2
Type:
Nuclear receptor co-regulator; EC 3.1.3.48; Protein phosphatase, dual-specificity
Mass (Da):
64987
Number AA:
580
UniProt ID:
P30305
International Prot ID:
IPI00216511
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0008284
Phosida
TranscriptoNet
STRING
Kinexus Products
Cell division cycle 25B phosphatase pan-specific antibody AB-NP002-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP002-2#Cell division cycle 25B phosphatase pan-specific antibody AB-NP002-2P#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP002-2P#Cell division cycle 25B phosphatase pan-specific antibody AB-NP002-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP002-3#Cell division cycle 25B phosphatase (M1-L14, human) peptide - Powder PE-01ASW95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ASW95#Cell division cycle 25B phosphatase (G394-G407, human) peptide - Powder PE-01ASX90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ASX90#Cell division cycle 25B phosphatase (A549-R562, human) peptide - Powder PE-01ASY75#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ASY75#Cell division cycle 25B phosphatase (A549-R562, human) peptide - Powder PE-01ASY75#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ASY75
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
Q
P
E
P
A
P
G
S
A
L
S
P
A
G
V
Site 2
S15
P
A
P
G
S
A
L
S
P
A
G
V
C
G
G
Site 3
S42
G
S
H
G
L
L
G
S
P
V
R
A
A
A
S
Site 4
S50
P
V
R
A
A
A
S
S
P
V
T
T
L
T
Q
Site 5
T53
A
A
A
S
S
P
V
T
T
L
T
Q
T
M
H
Site 6
T54
A
A
S
S
P
V
T
T
L
T
Q
T
M
H
D
Site 7
T56
S
S
P
V
T
T
L
T
Q
T
M
H
D
L
A
Site 8
T58
P
V
T
T
L
T
Q
T
M
H
D
L
A
G
L
Site 9
S67
H
D
L
A
G
L
G
S
E
T
P
K
S
Q
V
Site 10
T69
L
A
G
L
G
S
E
T
P
K
S
Q
V
G
T
Site 11
S72
L
G
S
E
T
P
K
S
Q
V
G
T
L
L
F
Site 12
T76
T
P
K
S
Q
V
G
T
L
L
F
R
S
R
S
Site 13
S81
V
G
T
L
L
F
R
S
R
S
R
L
T
H
L
Site 14
S83
T
L
L
F
R
S
R
S
R
L
T
H
L
S
L
Site 15
T86
F
R
S
R
S
R
L
T
H
L
S
L
S
R
R
Site 16
S89
R
S
R
L
T
H
L
S
L
S
R
R
A
S
E
Site 17
S91
R
L
T
H
L
S
L
S
R
R
A
S
E
S
S
Site 18
S95
L
S
L
S
R
R
A
S
E
S
S
L
S
S
E
Site 19
S97
L
S
R
R
A
S
E
S
S
L
S
S
E
S
S
Site 20
S98
S
R
R
A
S
E
S
S
L
S
S
E
S
S
E
Site 21
S100
R
A
S
E
S
S
L
S
S
E
S
S
E
S
S
Site 22
S101
A
S
E
S
S
L
S
S
E
S
S
E
S
S
D
Site 23
S103
E
S
S
L
S
S
E
S
S
E
S
S
D
A
G
Site 24
S104
S
S
L
S
S
E
S
S
E
S
S
D
A
G
L
Site 25
S106
L
S
S
E
S
S
E
S
S
D
A
G
L
C
M
Site 26
S107
S
S
E
S
S
E
S
S
D
A
G
L
C
M
D
Site 27
S115
D
A
G
L
C
M
D
S
P
S
P
M
D
P
H
Site 28
S117
G
L
C
M
D
S
P
S
P
M
D
P
H
M
A
Site 29
T127
D
P
H
M
A
E
Q
T
F
E
Q
A
I
Q
A
Site 30
S151
F
A
I
R
R
F
Q
S
M
P
V
R
L
L
G
Site 31
S160
P
V
R
L
L
G
H
S
P
V
L
R
N
I
T
Site 32
T167
S
P
V
L
R
N
I
T
N
S
Q
A
P
D
G
Site 33
S169
V
L
R
N
I
T
N
S
Q
A
P
D
G
R
R
Site 34
S178
A
P
D
G
R
R
K
S
E
A
G
S
G
A
A
Site 35
S182
R
R
K
S
E
A
G
S
G
A
A
S
S
S
G
Site 36
S186
E
A
G
S
G
A
A
S
S
S
G
E
D
K
E
Site 37
S187
A
G
S
G
A
A
S
S
S
G
E
D
K
E
N
Site 38
S188
G
S
G
A
A
S
S
S
G
E
D
K
E
N
D
Site 39
T206
F
K
M
P
W
K
P
T
H
P
S
S
T
H
A
Site 40
S209
P
W
K
P
T
H
P
S
S
T
H
A
L
A
E
Site 41
S210
W
K
P
T
H
P
S
S
T
H
A
L
A
E
W
Site 42
S219
H
A
L
A
E
W
A
S
R
R
E
A
F
A
Q
Site 43
S229
E
A
F
A
Q
R
P
S
S
A
P
D
L
M
C
Site 44
S230
A
F
A
Q
R
P
S
S
A
P
D
L
M
C
L
Site 45
S238
A
P
D
L
M
C
L
S
P
D
R
K
M
E
V
Site 46
S249
K
M
E
V
E
E
L
S
P
L
A
L
G
R
F
Site 47
S257
P
L
A
L
G
R
F
S
L
T
P
A
E
G
D
Site 48
T259
A
L
G
R
F
S
L
T
P
A
E
G
D
T
E
Site 49
T265
L
T
P
A
E
G
D
T
E
E
D
D
G
F
V
Site 50
S291
A
V
P
P
G
M
E
S
L
I
S
A
P
L
V
Site 51
T300
I
S
A
P
L
V
K
T
L
E
K
E
E
E
K
Site 52
S321
K
C
Q
R
L
F
R
S
P
S
M
P
C
S
V
Site 53
S323
Q
R
L
F
R
S
P
S
M
P
C
S
V
I
R
Site 54
S327
R
S
P
S
M
P
C
S
V
I
R
P
I
L
K
Site 55
T344
E
R
P
Q
D
R
D
T
P
V
Q
N
K
R
R
Site 56
S353
V
Q
N
K
R
R
R
S
V
T
P
P
E
E
Q
Site 57
T355
N
K
R
R
R
S
V
T
P
P
E
E
Q
Q
E
Site 58
S375
A
R
V
L
R
S
K
S
L
C
H
D
E
I
E
Site 59
S387
E
I
E
N
L
L
D
S
D
H
R
E
L
I
G
Site 60
Y396
H
R
E
L
I
G
D
Y
S
K
A
F
L
L
Q
Site 61
S397
R
E
L
I
G
D
Y
S
K
A
F
L
L
Q
T
Site 62
T404
S
K
A
F
L
L
Q
T
V
D
G
K
H
Q
D
Site 63
Y414
G
K
H
Q
D
L
K
Y
I
S
P
E
T
M
V
Site 64
S416
H
Q
D
L
K
Y
I
S
P
E
T
M
V
A
L
Site 65
Y442
F
V
I
V
D
C
R
Y
P
Y
E
Y
E
G
G
Site 66
Y444
I
V
D
C
R
Y
P
Y
E
Y
E
G
G
H
I
Site 67
Y446
D
C
R
Y
P
Y
E
Y
E
G
G
H
I
K
T
Site 68
S465
P
L
E
R
D
A
E
S
F
L
L
K
S
P
I
Site 69
Y511
R
D
R
A
V
N
D
Y
P
S
L
Y
Y
P
E
Site 70
S513
R
A
V
N
D
Y
P
S
L
Y
Y
P
E
M
Y
Site 71
Y515
V
N
D
Y
P
S
L
Y
Y
P
E
M
Y
I
L
Site 72
Y516
N
D
Y
P
S
L
Y
Y
P
E
M
Y
I
L
K
Site 73
Y520
S
L
Y
Y
P
E
M
Y
I
L
K
G
G
Y
K
Site 74
Y526
M
Y
I
L
K
G
G
Y
K
E
F
F
P
Q
H
Site 75
Y542
N
F
C
E
P
Q
D
Y
R
P
M
N
H
E
A
Site 76
T556
A
F
K
D
E
L
K
T
F
R
L
K
T
R
S
Site 77
T561
L
K
T
F
R
L
K
T
R
S
W
A
G
E
R
Site 78
S563
T
F
R
L
K
T
R
S
W
A
G
E
R
S
R
Site 79
S569
R
S
W
A
G
E
R
S
R
R
E
L
C
S
R
Site 80
S575
R
S
R
R
E
L
C
S
R
L
Q
D
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation