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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cdc25C
Full Name:
M-phase inducer phosphatase 3
Alias:
CDC25; CDC25M1; Cell division cycle 25 C; EC 3.1.3.48; M-phase inducer phosphatase 3; MPI1B; MPIP3
Type:
EC 3.1.3.48; Protein phosphatase, dual-specificity
Mass (Da):
53365
Number AA:
473
UniProt ID:
P30307
International Prot ID:
IPI00216683
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0050699
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0051301
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Cell division cycle 25C phosphatase pan-specific antibody AB-NP003-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP003-2#Cell division cycle 25C phosphatase pan-specific antibody AB-NP003-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP003-3#Cell division cycle 25C phosphatase (M1-E12, human) peptide - Powder PE-01AZQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AZQ95#Cell division cycle 25C phosphatase (E275-C290, human) peptide - Powder PE-01AZR99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AZR99#Cell division cycle 25C phosphatase (R458-S472, human) peptide - Powder PE-01AZS95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AZS95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
T
E
L
F
S
S
T
R
E
E
G
S
S
Site 2
T9
S
T
E
L
F
S
S
T
R
E
E
G
S
S
G
Site 3
S14
S
S
T
R
E
E
G
S
S
G
S
G
P
S
F
Site 4
S15
S
T
R
E
E
G
S
S
G
S
G
P
S
F
R
Site 5
S17
R
E
E
G
S
S
G
S
G
P
S
F
R
S
N
Site 6
S20
G
S
S
G
S
G
P
S
F
R
S
N
Q
R
K
Site 7
S23
G
S
G
P
S
F
R
S
N
Q
R
K
M
L
N
Site 8
T37
N
L
L
L
E
R
D
T
S
F
T
V
C
P
D
Site 9
S38
L
L
L
E
R
D
T
S
F
T
V
C
P
D
V
Site 10
T40
L
E
R
D
T
S
F
T
V
C
P
D
V
P
R
Site 11
T48
V
C
P
D
V
P
R
T
P
V
G
K
F
L
G
Site 12
S57
V
G
K
F
L
G
D
S
A
N
L
S
I
L
S
Site 13
S61
L
G
D
S
A
N
L
S
I
L
S
G
G
T
P
Site 14
S64
S
A
N
L
S
I
L
S
G
G
T
P
K
R
C
Site 15
T67
L
S
I
L
S
G
G
T
P
K
R
C
L
D
L
Site 16
S75
P
K
R
C
L
D
L
S
N
L
S
S
G
E
I
Site 17
S79
L
D
L
S
N
L
S
S
G
E
I
T
A
T
Q
Site 18
T83
N
L
S
S
G
E
I
T
A
T
Q
L
T
T
S
Site 19
T85
S
S
G
E
I
T
A
T
Q
L
T
T
S
A
D
Site 20
T96
T
S
A
D
L
D
E
T
G
H
L
D
S
S
G
Site 21
S102
E
T
G
H
L
D
S
S
G
L
Q
E
V
H
L
Site 22
S122
D
Q
H
L
M
K
C
S
P
A
Q
L
L
C
S
Site 23
S129
S
P
A
Q
L
L
C
S
T
P
N
G
L
D
R
Site 24
T130
P
A
Q
L
L
C
S
T
P
N
G
L
D
R
G
Site 25
S146
R
K
R
D
A
M
C
S
S
S
A
N
K
E
N
Site 26
S148
R
D
A
M
C
S
S
S
A
N
K
E
N
D
N
Site 27
S161
D
N
G
N
L
V
D
S
E
M
K
Y
L
G
S
Site 28
Y165
L
V
D
S
E
M
K
Y
L
G
S
P
I
T
T
Site 29
S168
S
E
M
K
Y
L
G
S
P
I
T
T
V
P
K
Site 30
T171
K
Y
L
G
S
P
I
T
T
V
P
K
L
D
K
Site 31
T172
Y
L
G
S
P
I
T
T
V
P
K
L
D
K
N
Site 32
S191
E
D
Q
A
E
E
I
S
D
E
L
M
E
F
S
Site 33
S198
S
D
E
L
M
E
F
S
L
K
D
Q
E
A
K
Site 34
S207
K
D
Q
E
A
K
V
S
R
S
G
L
Y
R
S
Site 35
S209
Q
E
A
K
V
S
R
S
G
L
Y
R
S
P
S
Site 36
Y212
K
V
S
R
S
G
L
Y
R
S
P
S
M
P
E
Site 37
S214
S
R
S
G
L
Y
R
S
P
S
M
P
E
N
L
Site 38
S216
S
G
L
Y
R
S
P
S
M
P
E
N
L
N
R
Site 39
T236
V
E
K
F
K
D
N
T
I
P
D
K
V
K
K
Site 40
Y245
P
D
K
V
K
K
K
Y
F
S
G
Q
G
K
L
Site 41
S247
K
V
K
K
K
Y
F
S
G
Q
G
K
L
R
K
Site 42
S263
L
C
L
K
K
T
V
S
L
C
D
I
T
I
T
Site 43
S277
T
Q
M
L
E
E
D
S
N
Q
G
H
L
I
G
Site 44
T294
S
K
V
C
A
L
P
T
V
S
G
K
H
Q
D
Site 45
Y304
G
K
H
Q
D
L
K
Y
V
N
P
E
T
V
A
Site 46
Y326
Q
G
L
I
E
K
F
Y
V
I
D
C
R
Y
P
Site 47
Y332
F
Y
V
I
D
C
R
Y
P
Y
E
Y
L
G
G
Site 48
Y334
V
I
D
C
R
Y
P
Y
E
Y
L
G
G
H
I
Site 49
Y336
D
C
R
Y
P
Y
E
Y
L
G
G
H
I
Q
G
Site 50
Y348
I
Q
G
A
L
N
L
Y
S
Q
E
E
L
F
N
Site 51
S349
Q
G
A
L
N
L
Y
S
Q
E
E
L
F
N
F
Site 52
S397
C
L
R
E
E
D
R
S
L
N
Q
Y
P
A
L
Site 53
Y401
E
D
R
S
L
N
Q
Y
P
A
L
Y
Y
P
E
Site 54
Y406
N
Q
Y
P
A
L
Y
Y
P
E
L
Y
I
L
K
Site 55
Y410
A
L
Y
Y
P
E
L
Y
I
L
K
G
G
Y
R
Site 56
Y416
L
Y
I
L
K
G
G
Y
R
D
F
F
P
E
Y
Site 57
Y423
Y
R
D
F
F
P
E
Y
M
E
L
C
E
P
Q
Site 58
T442
M
H
H
Q
D
H
K
T
E
L
L
R
C
R
S
Site 59
S449
T
E
L
L
R
C
R
S
Q
S
K
V
Q
E
G
Site 60
S451
L
L
R
C
R
S
Q
S
K
V
Q
E
G
E
R
Site 61
S472
A
L
L
V
K
D
M
S
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation