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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRKAR2B
Full Name:
cAMP-dependent protein kinase type II-beta regulatory subunit
Alias:
KAP3; PKA R2-beta; PRKAR2; Protein kinase, cAMP-dependent, regulatory, type II, beta
Type:
Protein-serine kinase regulatory subunit
Mass (Da):
46302
Number AA:
418
UniProt ID:
P31323
International Prot ID:
IPI00554752
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005952
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0030552
GO:0008603
PhosphoSite+
KinaseNET
Biological Process:
GO:0034199
GO:0009755
GO:0001932
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
T
E
L
L
Q
G
F
T
V
E
V
L
R
H
Q
Site 2
T48
Q
E
N
E
R
K
G
T
A
R
F
G
H
E
G
Site 3
T69
G
A
A
A
G
G
G
T
P
S
K
G
V
N
F
Site 4
S71
A
A
G
G
G
T
P
S
K
G
V
N
F
A
E
Site 5
S83
F
A
E
E
P
M
Q
S
D
S
E
D
G
E
E
Site 6
S85
E
E
P
M
Q
S
D
S
E
D
G
E
E
E
E
Site 7
S114
N
R
F
T
R
R
A
S
V
C
A
E
A
Y
N
Site 8
Y120
A
S
V
C
A
E
A
Y
N
P
D
E
E
E
D
Site 9
T138
S
R
I
I
H
P
K
T
D
D
Q
R
N
R
L
Site 10
S164
N
L
D
P
E
Q
M
S
Q
V
L
D
A
M
F
Site 11
Y192
G
D
D
G
D
N
F
Y
V
I
D
R
G
T
F
Site 12
Y202
D
R
G
T
F
D
I
Y
V
K
C
D
G
V
G
Site 13
Y215
V
G
R
C
V
G
N
Y
D
N
R
G
S
F
G
Site 14
S220
G
N
Y
D
N
R
G
S
F
G
E
L
A
L
M
Site 15
T235
Y
N
T
P
R
A
A
T
I
T
A
T
S
P
G
Site 16
Y267
N
A
K
K
R
K
M
Y
E
S
F
I
E
S
L
Site 17
S269
K
K
R
K
M
Y
E
S
F
I
E
S
L
P
F
Site 18
S279
E
S
L
P
F
L
K
S
L
E
F
S
E
R
L
Site 19
S283
F
L
K
S
L
E
F
S
E
R
L
K
V
V
D
Site 20
S312
A
Q
G
D
S
A
D
S
F
F
I
V
E
S
G
Site 21
T324
E
S
G
E
V
K
I
T
M
K
R
K
G
K
S
Site 22
S331
T
M
K
R
K
G
K
S
E
V
E
E
N
G
A
Site 23
S345
A
V
E
I
A
R
C
S
R
G
Q
Y
F
G
E
Site 24
T357
F
G
E
L
A
L
V
T
N
K
P
R
A
A
S
Site 25
S364
T
N
K
P
R
A
A
S
A
H
A
I
G
T
V
Site 26
Y399
M
K
R
N
I
A
T
Y
E
E
Q
L
V
A
L
Site 27
T417
N
M
D
I
V
E
P
T
A
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation