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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SFN
Full Name:
14-3-3 protein sigma
Alias:
1433S; 143S; Epithelial cell marker protein 1; HME1; Stratifin
Type:
Adapter/scaffold protein, 14-3-3 family
Mass (Da):
27774
Number AA:
248
UniProt ID:
P31947
International Prot ID:
IPI00013890
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005615
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0019904
GO:0008426
PhosphoSite+
KinaseNET
Biological Process:
GO:0008630
GO:0043154
GO:0006469
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
R
A
S
L
I
Q
K
A
K
L
Site 2
Y19
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
Site 3
S37
V
E
K
G
E
E
L
S
C
E
E
R
N
L
L
Site 4
S45
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
Site 5
Y48
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
Site 6
S63
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
Site 7
S64
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
Site 8
S69
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
Site 9
S74
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
Site 10
Y84
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
Site 11
T90
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
Site 12
T98
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
Site 13
S116
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
Site 14
Y120
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Site 15
Y127
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
Site 16
Y128
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
Site 17
Y130
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
Site 18
T136
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
Site 19
S146
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
Site 20
S149
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
Site 21
Y151
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
Site 22
T165
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
Site 23
Y181
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
Site 24
S186
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
Site 25
S192
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
Site 26
T207
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
Site 27
S209
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
Site 28
S212
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
Site 29
Y213
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Site 30
S216
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
Site 31
T217
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
Site 32
T228
Q
L
L
R
D
N
L
T
L
W
T
A
D
N
A
Site 33
S248
E
A
P
Q
E
P
Q
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation