KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
GRK4
Full Name:
G protein-coupled receptor kinase 4
Alias:
EC 2.7.11.16; GPRK2L; GPRK4; ITI1
Type:
Protein-serine kinase, AGC group, GRK family, GRK subfamily
Mass (Da):
66583
Number AA:
578
UniProt ID:
P32298
International Prot ID:
IPI00337306
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004703
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
L
K
A
R
Q
G
G
Y
G
K
K
S
G
R
S
Site 2
S24
Q
G
G
Y
G
K
K
S
G
R
S
K
K
W
K
Site 3
T35
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
Site 4
S43
L
P
P
V
S
Q
C
S
E
L
R
H
S
I
E
Site 5
S48
Q
C
S
E
L
R
H
S
I
E
K
D
Y
S
S
Site 6
Y53
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
Q
Site 7
S54
H
S
I
E
K
D
Y
S
S
L
C
D
K
Q
P
Site 8
S55
S
I
E
K
D
Y
S
S
L
C
D
K
Q
P
I
Site 9
T73
L
F
R
Q
F
C
D
T
K
P
T
L
K
R
H
Site 10
S99
V
A
D
D
E
D
R
S
D
C
G
L
S
I
L
Site 11
T127
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
Site 12
S139
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
Site 13
Y153
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
Site 14
Y162
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Site 15
S165
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Site 16
Y167
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
Site 17
T186
R
Q
P
V
T
K
N
T
F
R
H
Y
R
V
L
Site 18
Y190
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
Site 19
Y213
V
R
A
T
G
K
M
Y
A
C
K
K
L
Q
K
Site 20
Y254
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
Site 21
Y277
G
D
L
K
F
H
I
Y
N
L
G
N
P
G
F
Site 22
Y310
L
Q
R
E
R
I
V
Y
R
D
L
K
P
E
N
Site 23
S329
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
Site 24
T335
I
S
D
L
G
L
A
T
E
I
P
E
G
Q
R
Site 25
T349
R
V
R
G
R
V
G
T
V
G
Y
M
A
P
E
Site 26
Y363
E
V
V
N
N
E
K
Y
T
F
S
P
D
W
W
Site 27
S384
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
Site 28
Y389
G
H
S
P
F
K
K
Y
K
E
K
V
K
W
E
Site 29
T406
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
Site 30
Y409
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
Site 31
S410
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
Site 32
S414
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
Site 33
S419
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
Site 34
T426
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
Site 35
S430
M
L
L
T
K
N
P
S
K
R
L
G
C
R
G
Site 36
S485
V
L
D
I
E
Q
F
S
V
V
K
G
I
Y
L
Site 37
Y500
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
Site 38
S528
C
F
K
D
I
N
K
S
E
S
E
E
A
L
P
Site 39
S530
K
D
I
N
K
S
E
S
E
E
A
L
P
L
D
Site 40
T544
D
L
D
K
N
I
H
T
P
V
S
R
P
N
R
Site 41
S547
K
N
I
H
T
P
V
S
R
P
N
R
G
F
F
Site 42
Y555
R
P
N
R
G
F
F
Y
R
L
F
R
R
G
G
Site 43
T565
F
R
R
G
G
C
L
T
M
V
P
S
E
K
E
Site 44
S569
G
C
L
T
M
V
P
S
E
K
E
V
E
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation