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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CIITA
Full Name:
MHC class II transactivator
Alias:
C2TA; class II, major histocompatibility complex, transactivator; MHC class II transactivator CIITA; MHC2TA; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Type:
Transcription, coactivator/corepressor
Mass (Da):
123443
Number AA:
1130
UniProt ID:
P33076
International Prot ID:
IPI00186224
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003702
GO:0010843
PhosphoSite+
KinaseNET
Biological Process:
GO:0032966
GO:0010553
GO:0045348
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
A
P
R
P
A
G
S
Y
L
S
E
P
Q
G
Site 2
Y12
A
P
R
P
A
G
S
Y
L
S
E
P
Q
G
S
Site 3
S14
R
P
A
G
S
Y
L
S
E
P
Q
G
S
S
Q
Site 4
S20
L
S
E
P
Q
G
S
S
Q
C
A
T
M
E
L
Site 5
T24
Q
G
S
S
Q
C
A
T
M
E
L
G
P
L
E
Site 6
Y34
L
G
P
L
E
G
G
Y
L
E
L
L
N
S
D
Site 7
Y48
D
A
D
P
L
C
L
Y
H
F
Y
D
Q
M
D
Site 8
Y65
G
E
E
E
I
E
L
Y
S
E
P
D
T
D
T
Site 9
T70
E
L
Y
S
E
P
D
T
D
T
I
N
C
D
Q
Site 10
T72
Y
S
E
P
D
T
D
T
I
N
C
D
Q
F
S
Site 11
Y95
D
E
E
T
R
E
A
Y
A
N
I
A
E
L
D
Site 12
Y104
N
I
A
E
L
D
Q
Y
V
F
Q
D
S
Q
L
Site 13
S109
D
Q
Y
V
F
Q
D
S
Q
L
E
G
L
S
K
Site 14
S115
D
S
Q
L
E
G
L
S
K
D
I
F
K
H
I
Site 15
S142
P
A
E
V
G
Q
K
S
Q
K
R
P
F
P
E
Site 16
S197
L
F
N
Q
E
P
A
S
G
Q
M
R
L
E
K
Site 17
T205
G
Q
M
R
L
E
K
T
D
Q
I
P
M
P
F
Site 18
S218
P
F
S
S
S
S
L
S
C
L
N
L
P
E
G
Site 19
S244
P
H
G
L
W
Q
I
S
E
A
G
T
G
V
S
Site 20
S264
H
G
E
V
P
Q
A
S
Q
V
P
P
P
S
G
Site 21
T273
V
P
P
P
S
G
F
T
V
H
G
L
P
T
S
Site 22
S280
T
V
H
G
L
P
T
S
P
D
R
P
G
S
T
Site 23
S286
T
S
P
D
R
P
G
S
T
S
P
F
A
P
S
Site 24
S288
P
D
R
P
G
S
T
S
P
F
A
P
S
A
T
Site 25
S293
S
T
S
P
F
A
P
S
A
T
D
L
P
S
M
Site 26
T295
S
P
F
A
P
S
A
T
D
L
P
S
M
P
E
Site 27
S299
P
S
A
T
D
L
P
S
M
P
E
P
A
L
T
Site 28
T306
S
M
P
E
P
A
L
T
S
R
A
N
M
T
E
Site 29
S317
N
M
T
E
H
K
T
S
P
T
Q
C
P
A
A
Site 30
T319
T
E
H
K
T
S
P
T
Q
C
P
A
A
G
E
Site 31
Y342
P
E
P
V
E
Q
F
Y
R
S
L
Q
D
T
Y
Site 32
S344
P
V
E
Q
F
Y
R
S
L
Q
D
T
Y
G
A
Site 33
T348
F
Y
R
S
L
Q
D
T
Y
G
A
E
P
A
G
Site 34
Y349
Y
R
S
L
Q
D
T
Y
G
A
E
P
A
G
P
Site 35
S373
V
Q
A
R
L
E
R
S
S
S
K
S
L
E
R
Site 36
S374
Q
A
R
L
E
R
S
S
S
K
S
L
E
R
E
Site 37
S375
A
R
L
E
R
S
S
S
K
S
L
E
R
E
L
Site 38
S377
L
E
R
S
S
S
K
S
L
E
R
E
L
A
T
Site 39
T384
S
L
E
R
E
L
A
T
P
D
W
A
E
R
Q
Site 40
T413
E
H
R
R
P
R
E
T
R
V
I
A
V
L
G
Site 41
S427
G
K
A
G
Q
G
K
S
Y
W
A
G
A
V
S
Site 42
Y428
K
A
G
Q
G
K
S
Y
W
A
G
A
V
S
R
Site 43
S434
S
Y
W
A
G
A
V
S
R
A
W
A
C
G
R
Site 44
Y463
L
N
R
P
G
D
A
Y
G
L
Q
D
L
L
F
Site 45
S513
A
Q
D
G
F
L
H
S
T
C
G
P
A
P
A
Site 46
T514
Q
D
G
F
L
H
S
T
C
G
P
A
P
A
E
Site 47
T546
R
G
C
T
L
L
L
T
A
R
P
R
G
R
L
Site 48
S556
P
R
G
R
L
V
Q
S
L
S
K
A
D
A
L
Site 49
S558
G
R
L
V
Q
S
L
S
K
A
D
A
L
F
E
Site 50
Y577
S
M
E
Q
A
Q
A
Y
V
M
R
Y
F
E
S
Site 51
Y581
A
Q
A
Y
V
M
R
Y
F
E
S
S
G
M
T
Site 52
T596
E
H
Q
D
R
A
L
T
L
L
R
D
R
P
L
Site 53
S606
R
D
R
P
L
L
L
S
H
S
H
S
P
T
L
Site 54
S608
R
P
L
L
L
S
H
S
H
S
P
T
L
C
R
Site 55
T612
L
S
H
S
H
S
P
T
L
C
R
A
V
C
Q
Site 56
S635
G
E
D
A
K
L
P
S
T
L
T
G
L
Y
V
Site 57
T636
E
D
A
K
L
P
S
T
L
T
G
L
Y
V
G
Site 58
S673
E
L
G
R
R
H
Q
S
T
L
Q
E
D
Q
F
Site 59
T674
L
G
R
R
H
Q
S
T
L
Q
E
D
Q
F
P
Site 60
S704
H
P
P
R
A
A
E
S
E
L
A
F
P
S
F
Site 61
S725
G
A
L
W
L
A
L
S
G
E
I
K
D
K
E
Site 62
Y736
K
D
K
E
L
P
Q
Y
L
A
L
T
P
R
K
Site 63
T740
L
P
Q
Y
L
A
L
T
P
R
K
K
R
P
Y
Site 64
Y747
T
P
R
K
K
R
P
Y
D
N
W
L
E
G
V
Site 65
S781
L
G
P
S
A
A
A
S
V
D
R
K
Q
K
V
Site 66
Y792
K
Q
K
V
L
A
R
Y
L
K
R
L
Q
P
G
Site 67
T800
L
K
R
L
Q
P
G
T
L
R
A
R
Q
L
L
Site 68
S834
Q
E
L
P
G
R
L
S
F
L
G
T
R
L
T
Site 69
T838
G
R
L
S
F
L
G
T
R
L
T
P
P
D
A
Site 70
S860
E
A
A
G
Q
D
F
S
L
D
L
R
S
T
G
Site 71
S865
D
F
S
L
D
L
R
S
T
G
I
C
P
S
G
Site 72
S890
T
R
F
R
A
A
L
S
D
T
V
A
L
W
E
Site 73
S898
D
T
V
A
L
W
E
S
L
R
Q
H
G
E
T
Site 74
T916
Q
A
A
E
E
K
F
T
I
E
P
F
K
A
K
Site 75
S924
I
E
P
F
K
A
K
S
L
K
D
V
E
D
L
Site 76
T937
D
L
G
K
L
V
Q
T
Q
R
T
R
S
S
S
Site 77
S942
V
Q
T
Q
R
T
R
S
S
S
E
D
T
A
G
Site 78
S943
Q
T
Q
R
T
R
S
S
S
E
D
T
A
G
E
Site 79
S944
T
Q
R
T
R
S
S
S
E
D
T
A
G
E
L
Site 80
T947
T
R
S
S
S
E
D
T
A
G
E
L
P
A
V
Site 81
S968
E
F
A
L
G
P
V
S
G
P
Q
A
F
P
K
Site 82
S995
H
L
D
L
D
A
L
S
E
N
K
I
G
D
E
Site 83
S1005
K
I
G
D
E
G
V
S
Q
L
S
A
T
F
P
Site 84
S1008
D
E
G
V
S
Q
L
S
A
T
F
P
Q
L
K
Site 85
S1016
A
T
F
P
Q
L
K
S
L
E
T
L
N
L
S
Site 86
T1019
P
Q
L
K
S
L
E
T
L
N
L
S
Q
N
N
Site 87
S1023
S
L
E
T
L
N
L
S
Q
N
N
I
T
D
L
Site 88
S1050
A
A
S
L
L
R
L
S
L
Y
N
N
C
I
C
Site 89
S1073
R
V
L
P
D
M
V
S
L
R
V
M
D
V
Q
Site 90
Y1081
L
R
V
M
D
V
Q
Y
N
K
F
T
A
A
G
Site 91
S1095
G
A
Q
Q
L
A
A
S
L
R
R
C
P
H
V
Site 92
S1125
E
H
L
Q
Q
Q
D
S
R
I
S
L
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation