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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CRF-R1
Full Name:
Corticotropin-releasing factor receptor 1
Alias:
Corticotropin releasing factor receptor 1 precursor; Corticotropin releasing hormone receptor 1; Corticotropin-releasing factor receptor; Corticotropin-releasing hormone receptor 1; CRF1; CRFR; CRF-R; CRFR1; CRHR; CRH-R 1; CRHR1
Type:
G protein-coupled 7TM receptor
Mass (Da):
50719
Number AA:
444
UniProt ID:
P34998
International Prot ID:
IPI00003083
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0015056
PhosphoSite+
KinaseNET
Biological Process:
GO:0007188
GO:0007190
GO:0007565
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
L
G
L
N
P
V
S
A
S
L
Q
D
Q
H
Site 2
S24
G
L
N
P
V
S
A
S
L
Q
D
Q
H
C
E
Site 3
S32
L
Q
D
Q
H
C
E
S
L
S
L
A
S
N
I
Site 4
S34
D
Q
H
C
E
S
L
S
L
A
S
N
I
S
G
Site 5
Y73
R
P
C
P
A
F
F
Y
G
V
R
Y
N
T
T
Site 6
Y77
A
F
F
Y
G
V
R
Y
N
T
T
N
N
G
Y
Site 7
T79
F
Y
G
V
R
Y
N
T
T
N
N
G
Y
R
E
Site 8
Y99
S
W
A
A
R
V
N
Y
S
E
C
Q
E
I
L
Site 9
Y116
E
K
K
S
K
V
H
Y
H
V
A
V
I
I
N
Site 10
S175
A
P
F
Q
V
R
R
S
I
R
C
L
R
N
I
Site 11
S206
F
V
V
Q
L
T
M
S
P
E
V
H
Q
S
N
Site 12
S212
M
S
P
E
V
H
Q
S
N
V
G
W
C
R
L
Site 13
T252
A
I
V
L
T
Y
S
T
D
R
L
R
K
W
M
Site 14
Y296
F
G
K
R
P
G
V
Y
T
D
Y
I
Y
Q
G
Site 15
T297
G
K
R
P
G
V
Y
T
D
Y
I
Y
Q
G
P
Site 16
Y299
R
P
G
V
Y
T
D
Y
I
Y
Q
G
P
M
I
Site 17
S330
L
M
T
K
L
R
A
S
T
T
S
E
T
I
Q
Site 18
T331
M
T
K
L
R
A
S
T
T
S
E
T
I
Q
Y
Site 19
S333
K
L
R
A
S
T
T
S
E
T
I
Q
Y
R
K
Site 20
Y338
T
T
S
E
T
I
Q
Y
R
K
A
V
K
A
T
Site 21
S369
N
P
G
E
D
E
V
S
R
V
V
F
I
Y
F
Site 22
S401
F
L
N
S
E
V
R
S
A
I
R
K
R
W
H
Site 23
S425
A
R
V
A
R
A
M
S
I
P
T
S
P
T
R
Site 24
T428
A
R
A
M
S
I
P
T
S
P
T
R
V
S
F
Site 25
S429
R
A
M
S
I
P
T
S
P
T
R
V
S
F
H
Site 26
T431
M
S
I
P
T
S
P
T
R
V
S
F
H
S
I
Site 27
S434
P
T
S
P
T
R
V
S
F
H
S
I
K
Q
S
Site 28
S437
P
T
R
V
S
F
H
S
I
K
Q
S
T
A
V
Site 29
S441
S
F
H
S
I
K
Q
S
T
A
V
_
_
_
_
Site 30
T442
F
H
S
I
K
Q
S
T
A
V
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation