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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HePTP
Full Name:
Tyrosine-protein phosphatase non-receptor type 7
Alias:
EC 3.1.3.48; LC-PTP; Protein-tyrosine phosphatase, non-receptor type 7; PTN7; PTPN7
Type:
Protein phosphataseProtein-tyrosine phosphatase
Mass (Da):
40529
Number AA:
360
UniProt ID:
P35236
International Prot ID:
IPI00017338
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
R
S
R
A
Q
P
L
T
L
S
L
G
A
A
M
Site 2
T23
L
S
L
G
A
A
M
T
Q
P
P
P
E
K
T
Site 3
T30
T
Q
P
P
P
E
K
T
P
A
K
K
H
V
R
Site 4
S44
R
L
Q
E
R
R
G
S
N
V
A
L
M
L
D
Site 5
S54
A
L
M
L
D
V
R
S
L
G
A
V
E
P
I
Site 6
S63
G
A
V
E
P
I
C
S
V
N
T
P
R
E
V
Site 7
T66
E
P
I
C
S
V
N
T
P
R
E
V
T
L
H
Site 8
T71
V
N
T
P
R
E
V
T
L
H
F
L
R
T
A
Site 9
T83
R
T
A
G
H
P
L
T
R
W
A
L
Q
R
Q
Site 10
S93
A
L
Q
R
Q
P
P
S
P
K
Q
L
E
E
E
Site 11
S106
E
E
F
L
K
I
P
S
N
F
V
S
P
E
D
Site 12
S110
K
I
P
S
N
F
V
S
P
E
D
L
D
I
P
Site 13
Y125
G
H
A
S
K
D
R
Y
K
T
I
L
P
N
P
Site 14
T127
A
S
K
D
R
Y
K
T
I
L
P
N
P
Q
S
Site 15
S134
T
I
L
P
N
P
Q
S
R
V
C
L
G
R
A
Site 16
S143
V
C
L
G
R
A
Q
S
Q
E
D
G
D
Y
I
Site 17
Y149
Q
S
Q
E
D
G
D
Y
I
N
A
N
Y
I
R
Site 18
Y154
G
D
Y
I
N
A
N
Y
I
R
G
Y
D
G
K
Site 19
Y158
N
A
N
Y
I
R
G
Y
D
G
K
E
K
V
Y
Site 20
Y165
Y
D
G
K
E
K
V
Y
I
A
T
Q
G
P
M
Site 21
T168
K
E
K
V
Y
I
A
T
Q
G
P
M
P
N
T
Site 22
S177
G
P
M
P
N
T
V
S
D
F
W
E
M
V
W
Site 23
Y207
G
K
E
K
C
V
H
Y
W
P
T
E
E
E
T
Site 24
T214
Y
W
P
T
E
E
E
T
Y
G
P
F
Q
I
R
Site 25
Y215
W
P
T
E
E
E
T
Y
G
P
F
Q
I
R
I
Site 26
Y231
D
M
K
E
C
P
E
Y
T
V
R
Q
L
T
I
Site 27
T232
M
K
E
C
P
E
Y
T
V
R
Q
L
T
I
Q
Site 28
T237
E
Y
T
V
R
Q
L
T
I
Q
Y
Q
E
E
R
Site 29
S246
Q
Y
Q
E
E
R
R
S
V
K
H
I
L
F
S
Site 30
T260
S
A
W
P
D
H
Q
T
P
E
S
A
G
P
L
Site 31
S263
P
D
H
Q
T
P
E
S
A
G
P
L
L
R
L
Site 32
S277
L
V
A
E
V
E
E
S
P
E
T
A
A
H
P
Site 33
T280
E
V
E
E
S
P
E
T
A
A
H
P
G
P
I
Site 34
Y350
L
H
H
T
L
A
L
Y
A
G
Q
L
P
E
E
Site 35
S359
G
Q
L
P
E
E
P
S
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation