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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NF2
Full Name:
Merlin
Alias:
MERL; Moesin-ezrin-radixin-like protein; Neurofibromatosis-2; Neurofibromin 2; SCH; Schwannomerlin; Schwannomin
Type:
Cytoskeletal protein
Mass (Da):
69690
Number AA:
595
UniProt ID:
P35240
International Prot ID:
IPI00414431
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005769
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008092
PhosphoSite+
KinaseNET
Biological Process:
GO:0014010
GO:0030036
GO:0008156
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
A
I
A
S
R
M
S
F
S
S
L
K
R
K
Site 2
S13
A
S
R
M
S
F
S
S
L
K
R
K
Q
P
K
Site 3
T21
L
K
R
K
Q
P
K
T
F
T
V
R
I
V
T
Site 4
T23
R
K
Q
P
K
T
F
T
V
R
I
V
T
M
D
Site 5
T59
R
T
L
G
L
R
E
T
W
F
F
G
L
Q
Y
Site 6
S87
K
V
L
D
H
D
V
S
K
E
E
P
V
T
F
Site 7
T93
V
S
K
E
E
P
V
T
F
H
F
L
A
K
F
Site 8
Y101
F
H
F
L
A
K
F
Y
P
E
N
A
E
E
E
Site 9
Y132
Q
I
L
D
E
K
I
Y
C
P
P
E
A
S
V
Site 10
Y150
S
Y
A
V
Q
A
K
Y
G
D
Y
D
P
S
V
Site 11
Y153
V
Q
A
K
Y
G
D
Y
D
P
S
V
H
K
R
Site 12
S156
K
Y
G
D
Y
D
P
S
V
H
K
R
G
F
L
Site 13
Y177
P
K
R
V
I
N
L
Y
Q
M
T
P
E
M
W
Site 14
T180
V
I
N
L
Y
Q
M
T
P
E
M
W
E
E
R
Site 15
Y192
E
E
R
I
T
A
W
Y
A
E
H
R
G
R
A
Site 16
Y207
R
D
E
A
E
M
E
Y
L
K
I
A
Q
D
L
Site 17
Y221
L
E
M
Y
G
V
N
Y
F
A
I
R
N
K
K
Site 18
T230
A
I
R
N
K
K
G
T
E
L
L
L
G
V
D
Site 19
Y244
D
A
L
G
L
H
I
Y
D
P
E
N
R
L
T
Site 20
T251
Y
D
P
E
N
R
L
T
P
K
I
S
F
P
W
Site 21
S255
N
R
L
T
P
K
I
S
F
P
W
N
E
I
R
Site 22
S265
W
N
E
I
R
N
I
S
Y
S
D
K
E
F
T
Site 23
S267
E
I
R
N
I
S
Y
S
D
K
E
F
T
I
K
Site 24
T272
S
Y
S
D
K
E
F
T
I
K
P
L
D
K
K
Site 25
S288
D
V
F
K
F
N
S
S
K
L
R
V
N
K
L
Site 26
S315
M
R
R
R
K
A
D
S
L
E
V
Q
Q
M
K
Site 27
S444
A
L
K
M
A
E
E
S
E
R
R
A
K
E
A
Site 28
T477
Q
K
L
L
E
I
A
T
K
P
T
Y
P
P
M
Site 29
Y481
E
I
A
T
K
P
T
Y
P
P
M
N
P
I
P
Site 30
S497
P
L
P
P
D
I
P
S
F
N
L
I
G
D
S
Site 31
S504
S
F
N
L
I
G
D
S
L
S
F
D
F
K
D
Site 32
S506
N
L
I
G
D
S
L
S
F
D
F
K
D
T
D
Site 33
T512
L
S
F
D
F
K
D
T
D
M
K
R
L
S
M
Site 34
S518
D
T
D
M
K
R
L
S
M
E
I
E
K
E
K
Site 35
Y528
I
E
K
E
K
V
E
Y
M
E
K
S
K
H
L
Site 36
T544
E
Q
L
N
E
L
K
T
E
I
E
A
L
K
L
Site 37
T556
L
K
L
K
E
R
E
T
A
L
D
I
L
H
N
Site 38
S566
D
I
L
H
N
E
N
S
D
R
G
G
S
S
K
Site 39
S571
E
N
S
D
R
G
G
S
S
K
H
N
T
I
K
Site 40
T576
G
G
S
S
K
H
N
T
I
K
K
L
T
L
Q
Site 41
T581
H
N
T
I
K
K
L
T
L
Q
S
A
K
S
R
Site 42
S587
L
T
L
Q
S
A
K
S
R
V
A
F
F
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation