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Updated November 2019
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Protein Info
Short Name:
RFC1
Full Name:
Replication factor C subunit 1
Alias:
A1; A1 140 kDa; Activator 1 140 kDa; Activator 1 large subunit; Activator 1 subunit 1; DNA-binding protein PO-GA; MHCBFB; PO-GA; Replication factor C (activator 1) 1; Replication factor C large subunit; RF-C 140 kDa; RFC140
Type:
DNA replication protein
Mass (Da):
128255
Number AA:
1148
UniProt ID:
P35251
International Prot ID:
IPI00375358
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005663
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003689
GO:0008047
PhosphoSite+
KinaseNET
Biological Process:
GO:0006261
GO:0006297
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
K
K
N
E
K
T
K
S
D
E
E
T
L
K
A
Site 2
T33
K
T
K
S
D
E
E
T
L
K
A
K
K
G
I
Site 3
S47
I
K
E
I
K
V
N
S
S
R
K
E
D
D
F
Site 4
S60
D
F
K
Q
K
Q
P
S
K
K
K
R
I
I
Y
Site 5
Y67
S
K
K
K
R
I
I
Y
D
S
D
S
E
S
E
Site 6
S69
K
K
R
I
I
Y
D
S
D
S
E
S
E
E
T
Site 7
S71
R
I
I
Y
D
S
D
S
E
S
E
E
T
L
Q
Site 8
S73
I
Y
D
S
D
S
E
S
E
E
T
L
Q
V
K
Site 9
T76
S
D
S
E
S
E
E
T
L
Q
V
K
N
A
K
Site 10
S92
P
P
E
K
L
P
V
S
S
K
P
G
K
I
S
Site 11
S93
P
E
K
L
P
V
S
S
K
P
G
K
I
S
R
Site 12
S99
S
S
K
P
G
K
I
S
R
Q
D
P
V
T
Y
Site 13
T105
I
S
R
Q
D
P
V
T
Y
I
S
E
T
D
E
Site 14
S108
Q
D
P
V
T
Y
I
S
E
T
D
E
E
D
D
Site 15
T110
P
V
T
Y
I
S
E
T
D
E
E
D
D
F
M
Site 16
S125
C
K
K
A
A
S
K
S
K
E
N
G
R
S
T
Site 17
S131
K
S
K
E
N
G
R
S
T
N
S
H
L
G
T
Site 18
T132
S
K
E
N
G
R
S
T
N
S
H
L
G
T
S
Site 19
S134
E
N
G
R
S
T
N
S
H
L
G
T
S
N
M
Site 20
T138
S
T
N
S
H
L
G
T
S
N
M
K
K
N
E
Site 21
T150
K
N
E
E
N
T
K
T
K
N
K
P
L
S
P
Site 22
S156
K
T
K
N
K
P
L
S
P
I
K
L
T
P
T
Site 23
T161
P
L
S
P
I
K
L
T
P
T
S
V
L
D
Y
Site 24
T163
S
P
I
K
L
T
P
T
S
V
L
D
Y
F
G
Site 25
S164
P
I
K
L
T
P
T
S
V
L
D
Y
F
G
T
Site 26
Y168
T
P
T
S
V
L
D
Y
F
G
T
G
S
V
Q
Site 27
T171
S
V
L
D
Y
F
G
T
G
S
V
Q
R
S
N
Site 28
S173
L
D
Y
F
G
T
G
S
V
Q
R
S
N
K
K
Site 29
S177
G
T
G
S
V
Q
R
S
N
K
K
M
V
A
S
Site 30
S184
S
N
K
K
M
V
A
S
K
R
K
E
L
S
Q
Site 31
S190
A
S
K
R
K
E
L
S
Q
N
T
D
E
S
G
Site 32
T193
R
K
E
L
S
Q
N
T
D
E
S
G
L
N
D
Site 33
S196
L
S
Q
N
T
D
E
S
G
L
N
D
E
A
I
Site 34
T228
E
D
E
E
F
A
R
T
L
A
M
L
D
E
E
Site 35
T238
M
L
D
E
E
P
K
T
K
K
A
R
K
D
T
Site 36
T245
T
K
K
A
R
K
D
T
E
A
G
E
T
F
S
Site 37
T250
K
D
T
E
A
G
E
T
F
S
S
V
Q
A
N
Site 38
S253
E
A
G
E
T
F
S
S
V
Q
A
N
L
S
K
Site 39
S259
S
S
V
Q
A
N
L
S
K
A
E
K
H
K
Y
Site 40
Y266
S
K
A
E
K
H
K
Y
P
H
K
V
K
T
A
Site 41
T272
K
Y
P
H
K
V
K
T
A
Q
V
S
D
E
R
Site 42
S276
K
V
K
T
A
Q
V
S
D
E
R
K
S
Y
S
Site 43
S281
Q
V
S
D
E
R
K
S
Y
S
P
R
K
Q
S
Site 44
Y282
V
S
D
E
R
K
S
Y
S
P
R
K
Q
S
K
Site 45
S283
S
D
E
R
K
S
Y
S
P
R
K
Q
S
K
Y
Site 46
S288
S
Y
S
P
R
K
Q
S
K
Y
E
S
S
K
E
Site 47
Y290
S
P
R
K
Q
S
K
Y
E
S
S
K
E
S
Q
Site 48
S292
R
K
Q
S
K
Y
E
S
S
K
E
S
Q
Q
H
Site 49
S293
K
Q
S
K
Y
E
S
S
K
E
S
Q
Q
H
S
Site 50
S296
K
Y
E
S
S
K
E
S
Q
Q
H
S
K
S
S
Site 51
S300
S
K
E
S
Q
Q
H
S
K
S
S
A
D
K
I
Site 52
S302
E
S
Q
Q
H
S
K
S
S
A
D
K
I
G
E
Site 53
S311
A
D
K
I
G
E
V
S
S
P
K
A
S
S
K
Site 54
S312
D
K
I
G
E
V
S
S
P
K
A
S
S
K
L
Site 55
S316
E
V
S
S
P
K
A
S
S
K
L
A
I
M
K
Site 56
S317
V
S
S
P
K
A
S
S
K
L
A
I
M
K
R
Site 57
S329
M
K
R
K
E
E
S
S
Y
K
E
I
E
P
V
Site 58
Y330
K
R
K
E
E
S
S
Y
K
E
I
E
P
V
A
Site 59
S338
K
E
I
E
P
V
A
S
K
R
K
E
N
A
I
Site 60
T353
K
L
K
G
E
T
K
T
P
K
K
T
K
S
S
Site 61
T357
E
T
K
T
P
K
K
T
K
S
S
P
A
K
K
Site 62
S359
K
T
P
K
K
T
K
S
S
P
A
K
K
E
S
Site 63
S360
T
P
K
K
T
K
S
S
P
A
K
K
E
S
V
Site 64
S366
S
S
P
A
K
K
E
S
V
S
P
E
D
S
E
Site 65
S368
P
A
K
K
E
S
V
S
P
E
D
S
E
K
K
Site 66
S372
E
S
V
S
P
E
D
S
E
K
K
R
T
N
Y
Site 67
Y379
S
E
K
K
R
T
N
Y
Q
A
Y
R
S
Y
L
Site 68
Y382
K
R
T
N
Y
Q
A
Y
R
S
Y
L
N
R
E
Site 69
Y385
N
Y
Q
A
Y
R
S
Y
L
N
R
E
G
P
K
Site 70
S396
E
G
P
K
A
L
G
S
K
E
I
P
K
G
A
Site 71
S420
V
I
T
G
V
L
E
S
I
E
R
D
E
A
K
Site 72
S428
I
E
R
D
E
A
K
S
L
I
E
R
Y
G
G
Site 73
T445
T
G
N
V
S
K
K
T
N
Y
L
V
M
G
R
Site 74
Y447
N
V
S
K
K
T
N
Y
L
V
M
G
R
D
S
Site 75
S454
Y
L
V
M
G
R
D
S
G
Q
S
K
S
D
K
Site 76
S457
M
G
R
D
S
G
Q
S
K
S
D
K
A
A
A
Site 77
S459
R
D
S
G
Q
S
K
S
D
K
A
A
A
L
G
Site 78
T481
G
L
L
N
L
I
R
T
M
P
G
K
K
S
K
Site 79
Y489
M
P
G
K
K
S
K
Y
E
I
A
V
E
T
E
Site 80
T506
K
E
S
K
L
E
R
T
P
Q
K
N
V
Q
G
Site 81
S518
V
Q
G
K
R
K
I
S
P
S
K
K
E
S
E
Site 82
S520
G
K
R
K
I
S
P
S
K
K
E
S
E
S
K
Site 83
S524
I
S
P
S
K
K
E
S
E
S
K
K
S
R
P
Site 84
S526
P
S
K
K
E
S
E
S
K
K
S
R
P
T
S
Site 85
S529
K
E
S
E
S
K
K
S
R
P
T
S
K
R
D
Site 86
T532
E
S
K
K
S
R
P
T
S
K
R
D
S
L
A
Site 87
S533
S
K
K
S
R
P
T
S
K
R
D
S
L
A
K
Site 88
S537
R
P
T
S
K
R
D
S
L
A
K
T
I
K
K
Site 89
T541
K
R
D
S
L
A
K
T
I
K
K
E
T
D
V
Site 90
S552
E
T
D
V
F
W
K
S
L
D
F
K
E
Q
V
Site 91
T563
K
E
Q
V
A
E
E
T
S
G
D
S
K
A
R
Site 92
S564
E
Q
V
A
E
E
T
S
G
D
S
K
A
R
N
Site 93
S567
A
E
E
T
S
G
D
S
K
A
R
N
L
A
D
Site 94
S576
A
R
N
L
A
D
D
S
S
E
N
K
V
E
N
Site 95
S577
R
N
L
A
D
D
S
S
E
N
K
V
E
N
L
Site 96
Y590
N
L
L
W
V
D
K
Y
K
P
T
S
L
K
T
Site 97
S594
V
D
K
Y
K
P
T
S
L
K
T
I
I
G
Q
Site 98
S606
I
G
Q
Q
G
D
Q
S
C
A
N
K
L
L
R
Site 99
S621
W
L
R
N
W
Q
K
S
S
S
E
D
K
K
H
Site 100
S623
R
N
W
Q
K
S
S
S
E
D
K
K
H
A
A
Site 101
S636
A
A
K
F
G
K
F
S
G
K
D
D
G
S
S
Site 102
S642
F
S
G
K
D
D
G
S
S
F
K
A
A
L
L
Site 103
S643
S
G
K
D
D
G
S
S
F
K
A
A
L
L
S
Site 104
Y670
L
V
C
Q
E
L
G
Y
S
Y
V
E
L
N
A
Site 105
S671
V
C
Q
E
L
G
Y
S
Y
V
E
L
N
A
S
Site 106
Y672
C
Q
E
L
G
Y
S
Y
V
E
L
N
A
S
D
Site 107
S678
S
Y
V
E
L
N
A
S
D
T
R
S
K
S
S
Site 108
T680
V
E
L
N
A
S
D
T
R
S
K
S
S
L
K
Site 109
S682
L
N
A
S
D
T
R
S
K
S
S
L
K
A
I
Site 110
S684
A
S
D
T
R
S
K
S
S
L
K
A
I
V
A
Site 111
S685
S
D
T
R
S
K
S
S
L
K
A
I
V
A
E
Site 112
T697
V
A
E
S
L
N
N
T
S
I
K
G
F
Y
S
Site 113
S704
T
S
I
K
G
F
Y
S
N
G
A
A
S
S
V
Site 114
S710
Y
S
N
G
A
A
S
S
V
S
T
K
H
A
L
Site 115
Y766
K
I
R
S
L
V
H
Y
C
F
D
L
R
F
Q
Site 116
T829
C
A
R
S
K
A
L
T
Y
D
Q
A
K
A
D
Site 117
S837
Y
D
Q
A
K
A
D
S
H
R
A
K
K
D
I
Site 118
S866
G
E
E
T
A
H
M
S
L
V
D
K
S
D
L
Site 119
S914
L
L
S
R
A
A
D
S
I
C
D
G
D
L
V
Site 120
S923
C
D
G
D
L
V
D
S
Q
I
R
S
K
Q
N
Site 121
S927
L
V
D
S
Q
I
R
S
K
Q
N
W
S
L
L
Site 122
S932
I
R
S
K
Q
N
W
S
L
L
P
A
Q
A
I
Site 123
Y952
P
G
E
L
M
R
G
Y
M
T
Q
F
P
T
F
Site 124
T954
E
L
M
R
G
Y
M
T
Q
F
P
T
F
P
S
Site 125
S961
T
Q
F
P
T
F
P
S
W
L
G
K
H
S
S
Site 126
S967
P
S
W
L
G
K
H
S
S
T
G
K
H
D
R
Site 127
S968
S
W
L
G
K
H
S
S
T
G
K
H
D
R
I
Site 128
S984
Q
D
L
A
L
H
M
S
L
R
T
Y
S
S
K
Site 129
Y988
L
H
M
S
L
R
T
Y
S
S
K
R
T
V
N
Site 130
S989
H
M
S
L
R
T
Y
S
S
K
R
T
V
N
M
Site 131
S990
M
S
L
R
T
Y
S
S
K
R
T
V
N
M
D
Site 132
T993
R
T
Y
S
S
K
R
T
V
N
M
D
Y
L
S
Site 133
Y998
K
R
T
V
N
M
D
Y
L
S
L
L
R
D
A
Site 134
Y1029
V
A
L
M
D
T
Y
Y
L
M
K
E
D
F
E
Site 135
S1043
E
N
I
M
E
I
S
S
W
G
G
K
P
S
P
Site 136
S1049
S
S
W
G
G
K
P
S
P
F
S
K
L
D
P
Site 137
S1052
G
G
K
P
S
P
F
S
K
L
D
P
K
V
K
Site 138
Y1066
K
A
A
F
T
R
A
Y
N
K
E
A
H
L
T
Site 139
T1073
Y
N
K
E
A
H
L
T
P
Y
S
L
Q
A
I
Site 140
S1076
E
A
H
L
T
P
Y
S
L
Q
A
I
K
A
S
Site 141
S1083
S
L
Q
A
I
K
A
S
R
H
S
T
S
P
S
Site 142
S1086
A
I
K
A
S
R
H
S
T
S
P
S
L
D
S
Site 143
T1087
I
K
A
S
R
H
S
T
S
P
S
L
D
S
E
Site 144
S1088
K
A
S
R
H
S
T
S
P
S
L
D
S
E
Y
Site 145
S1090
S
R
H
S
T
S
P
S
L
D
S
E
Y
N
E
Site 146
S1093
S
T
S
P
S
L
D
S
E
Y
N
E
E
L
N
Site 147
Y1095
S
P
S
L
D
S
E
Y
N
E
E
L
N
E
D
Site 148
S1104
E
E
L
N
E
D
D
S
Q
S
D
E
K
D
Q
Site 149
S1106
L
N
E
D
D
S
Q
S
D
E
K
D
Q
D
A
Site 150
T1116
K
D
Q
D
A
I
E
T
D
A
M
I
K
K
K
Site 151
T1124
D
A
M
I
K
K
K
T
K
S
S
K
P
S
K
Site 152
S1126
M
I
K
K
K
T
K
S
S
K
P
S
K
P
E
Site 153
S1127
I
K
K
K
T
K
S
S
K
P
S
K
P
E
K
Site 154
S1130
K
T
K
S
S
K
P
S
K
P
E
K
D
K
E
Site 155
S1145
P
R
K
G
K
G
K
S
S
K
K
_
_
_
_
Site 156
S1146
R
K
G
K
G
K
S
S
K
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation