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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Adrenergic receptor-alpha1B
Full Name:
Alpha-1B adrenergic receptor
Alias:
Alpha-1B adrenoreceptor
Type:
G protein-coupled 7TM receptor
Mass (Da):
56836
Number AA:
519
UniProt ID:
P35368
International Prot ID:
IPI00218912
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004937
PhosphoSite+
KinaseNET
Biological Process:
GO:0007188
GO:0008283
GO:0007267
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
N
P
D
L
D
T
G
H
N
T
S
A
P
Site 2
T11
D
L
D
T
G
H
N
T
S
A
P
A
H
W
G
Site 3
S33
T
G
P
N
Q
T
S
S
N
S
T
L
P
Q
L
Site 4
T36
N
Q
T
S
S
N
S
T
L
P
Q
L
D
I
T
Site 5
T78
A
C
N
R
H
L
R
T
P
T
N
Y
F
I
V
Site 6
T80
N
R
H
L
R
T
P
T
N
Y
F
I
V
N
L
Site 7
Y144
C
A
I
S
I
D
R
Y
I
G
V
R
Y
S
L
Site 8
Y149
D
R
Y
I
G
V
R
Y
S
L
Q
Y
P
T
L
Site 9
S150
R
Y
I
G
V
R
Y
S
L
Q
Y
P
T
L
V
Site 10
Y153
G
V
R
Y
S
L
Q
Y
P
T
L
V
T
R
R
Site 11
T198
D
D
K
E
C
G
V
T
E
E
P
F
Y
A
L
Site 12
T234
Y
I
V
A
K
R
T
T
K
N
L
E
A
G
V
Site 13
S248
V
M
K
E
M
S
N
S
K
E
L
T
L
R
I
Site 14
T252
M
S
N
S
K
E
L
T
L
R
I
H
S
K
N
Site 15
S257
E
L
T
L
R
I
H
S
K
N
F
H
E
D
T
Site 16
T264
S
K
N
F
H
E
D
T
L
S
S
T
K
A
K
Site 17
S266
N
F
H
E
D
T
L
S
S
T
K
A
K
G
H
Site 18
S267
F
H
E
D
T
L
S
S
T
K
A
K
G
H
N
Site 19
S277
A
K
G
H
N
P
R
S
S
I
A
V
K
L
F
Site 20
S278
K
G
H
N
P
R
S
S
I
A
V
K
L
F
K
Site 21
Y348
S
C
L
N
P
I
I
Y
P
C
S
S
K
E
F
Site 22
S351
N
P
I
I
Y
P
C
S
S
K
E
F
K
R
A
Site 23
Y386
R
R
L
G
G
C
A
Y
T
Y
R
P
W
T
R
Site 24
Y388
L
G
G
C
A
Y
T
Y
R
P
W
T
R
G
G
Site 25
T392
A
Y
T
Y
R
P
W
T
R
G
G
S
L
E
R
Site 26
S396
R
P
W
T
R
G
G
S
L
E
R
S
Q
S
R
Site 27
S400
R
G
G
S
L
E
R
S
Q
S
R
K
D
S
L
Site 28
S402
G
S
L
E
R
S
Q
S
R
K
D
S
L
D
D
Site 29
S406
R
S
Q
S
R
K
D
S
L
D
D
S
G
S
C
Site 30
S410
R
K
D
S
L
D
D
S
G
S
C
L
S
G
S
Site 31
S412
D
S
L
D
D
S
G
S
C
L
S
G
S
Q
R
Site 32
S415
D
D
S
G
S
C
L
S
G
S
Q
R
T
L
P
Site 33
S417
S
G
S
C
L
S
G
S
Q
R
T
L
P
S
A
Site 34
S423
G
S
Q
R
T
L
P
S
A
S
P
S
P
G
Y
Site 35
S425
Q
R
T
L
P
S
A
S
P
S
P
G
Y
L
G
Site 36
S427
T
L
P
S
A
S
P
S
P
G
Y
L
G
R
G
Site 37
Y430
S
A
S
P
S
P
G
Y
L
G
R
G
A
P
P
Site 38
S455
K
A
P
G
A
L
L
S
L
P
A
P
E
P
P
Site 39
S470
G
R
R
G
R
H
D
S
G
P
L
F
T
F
K
Site 40
T475
H
D
S
G
P
L
F
T
F
K
L
L
T
E
P
Site 41
T480
L
F
T
F
K
L
L
T
E
P
E
S
P
G
T
Site 42
S484
K
L
L
T
E
P
E
S
P
G
T
D
G
G
A
Site 43
T487
T
E
P
E
S
P
G
T
D
G
G
A
S
N
G
Site 44
S492
P
G
T
D
G
G
A
S
N
G
G
C
E
A
A
Site 45
S511
N
G
Q
P
G
F
K
S
N
M
P
L
A
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation