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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRS1
Full Name:
Insulin receptor substrate 1
Alias:
HIRS-1; Insulin receptor substrate-1; IRS-1
Type:
Adapter/scaffold protein
Mass (Da):
131591
Number AA:
1242
UniProt ID:
P35568
International Prot ID:
IPI00019471
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005901
GO:0005737
GO:0005899
Uniprot
OncoNet
Molecular Function:
GO:0042169
GO:0005158
GO:0005159
PhosphoSite+
KinaseNET
Biological Process:
GO:0042593
GO:0008286
GO:0048009
Phosida
TranscriptoNet
STRING
Kinexus Products
Insulin receptor substrate 1 (K891-G902) mouse, peptide - Powder PE-01ADA95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADA95#Insulin receptor substrate 1 (K891-G902) mouse, peptide - Powder PE-01AQD95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AQD95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
P
P
E
S
D
G
F
Site 2
S7
_
M
A
S
P
P
E
S
D
G
F
S
D
V
R
Site 3
S11
P
P
E
S
D
G
F
S
D
V
R
K
V
G
Y
Site 4
Y18
S
D
V
R
K
V
G
Y
L
R
K
P
K
S
M
Site 5
S24
G
Y
L
R
K
P
K
S
M
H
K
R
F
F
V
Site 6
Y46
G
G
P
A
R
L
E
Y
Y
E
N
E
K
K
W
Site 7
Y47
G
P
A
R
L
E
Y
Y
E
N
E
K
K
W
R
Site 8
S57
E
K
K
W
R
H
K
S
S
A
P
K
R
S
I
Site 9
S58
K
K
W
R
H
K
S
S
A
P
K
R
S
I
P
Site 10
S63
K
S
S
A
P
K
R
S
I
P
L
E
S
C
F
Site 11
S78
N
I
N
K
R
A
D
S
K
N
K
H
L
V
A
Site 12
Y87
N
K
H
L
V
A
L
Y
T
R
D
E
H
F
A
Site 13
S99
H
F
A
I
A
A
D
S
E
A
E
Q
D
S
W
Site 14
S105
D
S
E
A
E
Q
D
S
W
Y
Q
A
L
L
Q
Site 15
Y107
E
A
E
Q
D
S
W
Y
Q
A
L
L
Q
L
H
Site 16
S135
G
A
G
G
G
G
G
S
C
S
G
S
S
G
L
Site 17
S137
G
G
G
G
G
S
C
S
G
S
S
G
L
G
E
Site 18
S139
G
G
G
S
C
S
G
S
S
G
L
G
E
A
G
Site 19
S150
G
E
A
G
E
D
L
S
Y
G
D
V
P
P
G
Site 20
Y151
E
A
G
E
D
L
S
Y
G
D
V
P
P
G
P
Site 21
Y183
T
K
N
L
I
G
I
Y
R
L
C
L
T
S
K
Site 22
S261
L
E
A
M
R
A
M
S
D
E
F
R
P
R
S
Site 23
S268
S
D
E
F
R
P
R
S
K
S
Q
S
S
S
N
Site 24
S270
E
F
R
P
R
S
K
S
Q
S
S
S
N
C
S
Site 25
S272
R
P
R
S
K
S
Q
S
S
S
N
C
S
N
P
Site 26
S273
P
R
S
K
S
Q
S
S
S
N
C
S
N
P
I
Site 27
S274
R
S
K
S
Q
S
S
S
N
C
S
N
P
I
S
Site 28
S277
S
Q
S
S
S
N
C
S
N
P
I
S
V
P
L
Site 29
S281
S
N
C
S
N
P
I
S
V
P
L
R
R
H
H
Site 30
S295
H
L
N
N
P
P
P
S
Q
V
G
L
T
R
R
Site 31
T300
P
P
S
Q
V
G
L
T
R
R
S
R
T
E
S
Site 32
S303
Q
V
G
L
T
R
R
S
R
T
E
S
I
T
A
Site 33
T305
G
L
T
R
R
S
R
T
E
S
I
T
A
T
S
Site 34
S307
T
R
R
S
R
T
E
S
I
T
A
T
S
P
A
Site 35
T309
R
S
R
T
E
S
I
T
A
T
S
P
A
S
M
Site 36
T311
R
T
E
S
I
T
A
T
S
P
A
S
M
V
G
Site 37
S312
T
E
S
I
T
A
T
S
P
A
S
M
V
G
G
Site 38
S315
I
T
A
T
S
P
A
S
M
V
G
G
K
P
G
Site 39
S323
M
V
G
G
K
P
G
S
F
R
V
R
A
S
S
Site 40
S329
G
S
F
R
V
R
A
S
S
D
G
E
G
T
M
Site 41
S330
S
F
R
V
R
A
S
S
D
G
E
G
T
M
S
Site 42
T335
A
S
S
D
G
E
G
T
M
S
R
P
A
S
V
Site 43
S337
S
D
G
E
G
T
M
S
R
P
A
S
V
D
G
Site 44
S341
G
T
M
S
R
P
A
S
V
D
G
S
P
V
S
Site 45
S345
R
P
A
S
V
D
G
S
P
V
S
P
S
T
N
Site 46
S348
S
V
D
G
S
P
V
S
P
S
T
N
R
T
H
Site 47
S350
D
G
S
P
V
S
P
S
T
N
R
T
H
A
H
Site 48
T351
G
S
P
V
S
P
S
T
N
R
T
H
A
H
R
Site 49
T354
V
S
P
S
T
N
R
T
H
A
H
R
H
R
G
Site 50
S362
H
A
H
R
H
R
G
S
A
R
L
H
P
P
L
Site 51
S372
L
H
P
P
L
N
H
S
R
S
I
P
M
P
A
Site 52
S374
P
P
L
N
H
S
R
S
I
P
M
P
A
S
R
Site 53
S380
R
S
I
P
M
P
A
S
R
C
S
P
S
A
T
Site 54
S383
P
M
P
A
S
R
C
S
P
S
A
T
S
P
V
Site 55
S385
P
A
S
R
C
S
P
S
A
T
S
P
V
S
L
Site 56
T387
S
R
C
S
P
S
A
T
S
P
V
S
L
S
S
Site 57
S388
R
C
S
P
S
A
T
S
P
V
S
L
S
S
S
Site 58
S391
P
S
A
T
S
P
V
S
L
S
S
S
S
T
S
Site 59
S393
A
T
S
P
V
S
L
S
S
S
S
T
S
G
H
Site 60
S394
T
S
P
V
S
L
S
S
S
S
T
S
G
H
G
Site 61
S395
S
P
V
S
L
S
S
S
S
T
S
G
H
G
S
Site 62
S396
P
V
S
L
S
S
S
S
T
S
G
H
G
S
T
Site 63
T397
V
S
L
S
S
S
S
T
S
G
H
G
S
T
S
Site 64
S398
S
L
S
S
S
S
T
S
G
H
G
S
T
S
D
Site 65
S402
S
S
T
S
G
H
G
S
T
S
D
C
L
F
P
Site 66
S404
T
S
G
H
G
S
T
S
D
C
L
F
P
R
R
Site 67
S412
D
C
L
F
P
R
R
S
S
A
S
V
S
G
S
Site 68
S413
C
L
F
P
R
R
S
S
A
S
V
S
G
S
P
Site 69
S415
F
P
R
R
S
S
A
S
V
S
G
S
P
S
D
Site 70
S417
R
R
S
S
A
S
V
S
G
S
P
S
D
G
G
Site 71
S419
S
S
A
S
V
S
G
S
P
S
D
G
G
F
I
Site 72
S421
A
S
V
S
G
S
P
S
D
G
G
F
I
S
S
Site 73
S427
P
S
D
G
G
F
I
S
S
D
E
Y
G
S
S
Site 74
S428
S
D
G
G
F
I
S
S
D
E
Y
G
S
S
P
Site 75
Y431
G
F
I
S
S
D
E
Y
G
S
S
P
C
D
F
Site 76
S434
S
S
D
E
Y
G
S
S
P
C
D
F
R
S
S
Site 77
S440
S
S
P
C
D
F
R
S
S
F
R
S
V
T
P
Site 78
S441
S
P
C
D
F
R
S
S
F
R
S
V
T
P
D
Site 79
S444
D
F
R
S
S
F
R
S
V
T
P
D
S
L
G
Site 80
T446
R
S
S
F
R
S
V
T
P
D
S
L
G
H
T
Site 81
S449
F
R
S
V
T
P
D
S
L
G
H
T
P
P
A
Site 82
T453
T
P
D
S
L
G
H
T
P
P
A
R
G
E
E
Site 83
S463
A
R
G
E
E
E
L
S
N
Y
I
C
M
G
G
Site 84
Y465
G
E
E
E
L
S
N
Y
I
C
M
G
G
K
G
Site 85
T475
M
G
G
K
G
P
S
T
L
T
A
P
N
G
H
Site 86
T477
G
K
G
P
S
T
L
T
A
P
N
G
H
Y
I
Site 87
Y483
L
T
A
P
N
G
H
Y
I
L
S
R
G
G
N
Site 88
S486
P
N
G
H
Y
I
L
S
R
G
G
N
G
H
R
Site 89
T495
G
G
N
G
H
R
C
T
P
G
T
G
L
G
T
Site 90
T498
G
H
R
C
T
P
G
T
G
L
G
T
S
P
A
Site 91
S503
P
G
T
G
L
G
T
S
P
A
L
A
G
D
E
Site 92
T525
D
N
R
F
R
K
R
T
H
S
A
G
T
S
P
Site 93
S527
R
F
R
K
R
T
H
S
A
G
T
S
P
T
I
Site 94
T530
K
R
T
H
S
A
G
T
S
P
T
I
T
H
Q
Site 95
S531
R
T
H
S
A
G
T
S
P
T
I
T
H
Q
K
Site 96
T535
A
G
T
S
P
T
I
T
H
Q
K
T
P
S
Q
Site 97
T539
P
T
I
T
H
Q
K
T
P
S
Q
S
S
V
A
Site 98
S541
I
T
H
Q
K
T
P
S
Q
S
S
V
A
S
I
Site 99
S544
Q
K
T
P
S
Q
S
S
V
A
S
I
E
E
Y
Site 100
S547
P
S
Q
S
S
V
A
S
I
E
E
Y
T
E
M
Site 101
Y551
S
V
A
S
I
E
E
Y
T
E
M
M
P
A
Y
Site 102
Y558
Y
T
E
M
M
P
A
Y
P
P
G
G
G
S
G
Site 103
S564
A
Y
P
P
G
G
G
S
G
G
R
L
P
G
H
Site 104
S574
R
L
P
G
H
R
H
S
A
F
V
P
T
R
S
Site 105
S581
S
A
F
V
P
T
R
S
Y
P
E
E
G
L
E
Site 106
Y582
A
F
V
P
T
R
S
Y
P
E
E
G
L
E
M
Site 107
S603
G
G
H
H
R
P
D
S
S
T
L
H
T
D
D
Site 108
S604
G
H
H
R
P
D
S
S
T
L
H
T
D
D
G
Site 109
T605
H
H
R
P
D
S
S
T
L
H
T
D
D
G
Y
Site 110
T608
P
D
S
S
T
L
H
T
D
D
G
Y
M
P
M
Site 111
Y612
T
L
H
T
D
D
G
Y
M
P
M
S
P
G
V
Site 112
S616
D
D
G
Y
M
P
M
S
P
G
V
A
P
V
P
Site 113
S624
P
G
V
A
P
V
P
S
G
R
K
G
S
G
D
Site 114
S629
V
P
S
G
R
K
G
S
G
D
Y
M
P
M
S
Site 115
Y632
G
R
K
G
S
G
D
Y
M
P
M
S
P
K
S
Site 116
S636
S
G
D
Y
M
P
M
S
P
K
S
V
S
A
P
Site 117
S639
Y
M
P
M
S
P
K
S
V
S
A
P
Q
Q
I
Site 118
S641
P
M
S
P
K
S
V
S
A
P
Q
Q
I
I
N
Site 119
Y662
Q
R
V
D
P
N
G
Y
M
M
M
S
P
S
G
Site 120
S666
P
N
G
Y
M
M
M
S
P
S
G
G
C
S
P
Site 121
S668
G
Y
M
M
M
S
P
S
G
G
C
S
P
D
I
Site 122
S672
M
S
P
S
G
G
C
S
P
D
I
G
G
G
P
Site 123
S680
P
D
I
G
G
G
P
S
S
S
S
S
S
S
N
Site 124
S681
D
I
G
G
G
P
S
S
S
S
S
S
S
N
A
Site 125
S682
I
G
G
G
P
S
S
S
S
S
S
S
N
A
V
Site 126
S683
G
G
G
P
S
S
S
S
S
S
S
N
A
V
P
Site 127
S684
G
G
P
S
S
S
S
S
S
S
N
A
V
P
S
Site 128
S685
G
P
S
S
S
S
S
S
S
N
A
V
P
S
G
Site 129
S686
P
S
S
S
S
S
S
S
N
A
V
P
S
G
T
Site 130
S691
S
S
S
N
A
V
P
S
G
T
S
Y
G
K
L
Site 131
S694
N
A
V
P
S
G
T
S
Y
G
K
L
W
T
N
Site 132
Y695
A
V
P
S
G
T
S
Y
G
K
L
W
T
N
G
Site 133
S708
N
G
V
G
G
H
H
S
H
V
L
P
H
P
K
Site 134
T729
G
G
K
L
L
P
C
T
G
D
Y
M
N
M
S
Site 135
Y732
L
L
P
C
T
G
D
Y
M
N
M
S
P
V
G
Site 136
S736
T
G
D
Y
M
N
M
S
P
V
G
D
S
N
T
Site 137
S741
N
M
S
P
V
G
D
S
N
T
S
S
P
S
D
Site 138
T743
S
P
V
G
D
S
N
T
S
S
P
S
D
C
Y
Site 139
S744
P
V
G
D
S
N
T
S
S
P
S
D
C
Y
Y
Site 140
S745
V
G
D
S
N
T
S
S
P
S
D
C
Y
Y
G
Site 141
S747
D
S
N
T
S
S
P
S
D
C
Y
Y
G
P
E
Site 142
Y750
T
S
S
P
S
D
C
Y
Y
G
P
E
D
P
Q
Site 143
Y751
S
S
P
S
D
C
Y
Y
G
P
E
D
P
Q
H
Site 144
S763
P
Q
H
K
P
V
L
S
Y
Y
S
L
P
R
S
Site 145
Y765
H
K
P
V
L
S
Y
Y
S
L
P
R
S
F
K
Site 146
S766
K
P
V
L
S
Y
Y
S
L
P
R
S
F
K
H
Site 147
S770
S
Y
Y
S
L
P
R
S
F
K
H
T
Q
R
P
Site 148
T774
L
P
R
S
F
K
H
T
Q
R
P
G
E
P
E
Site 149
S792
R
H
Q
H
L
R
L
S
T
S
S
G
R
L
L
Site 150
T793
H
Q
H
L
R
L
S
T
S
S
G
R
L
L
Y
Site 151
S794
Q
H
L
R
L
S
T
S
S
G
R
L
L
Y
A
Site 152
S795
H
L
R
L
S
T
S
S
G
R
L
L
Y
A
A
Site 153
Y800
T
S
S
G
R
L
L
Y
A
A
T
A
D
D
S
Site 154
T803
G
R
L
L
Y
A
A
T
A
D
D
S
S
S
S
Site 155
S807
Y
A
A
T
A
D
D
S
S
S
S
T
S
S
D
Site 156
S808
A
A
T
A
D
D
S
S
S
S
T
S
S
D
S
Site 157
S809
A
T
A
D
D
S
S
S
S
T
S
S
D
S
L
Site 158
S810
T
A
D
D
S
S
S
S
T
S
S
D
S
L
G
Site 159
T811
A
D
D
S
S
S
S
T
S
S
D
S
L
G
G
Site 160
S812
D
D
S
S
S
S
T
S
S
D
S
L
G
G
G
Site 161
S813
D
S
S
S
S
T
S
S
D
S
L
G
G
G
Y
Site 162
S815
S
S
S
T
S
S
D
S
L
G
G
G
Y
C
G
Site 163
S828
C
G
A
R
L
E
P
S
L
P
H
P
H
H
Q
Site 164
T847
H
L
P
R
K
V
D
T
A
A
Q
T
N
S
R
Site 165
S853
D
T
A
A
Q
T
N
S
R
L
A
R
P
T
R
Site 166
T859
N
S
R
L
A
R
P
T
R
L
S
L
G
D
P
Site 167
S862
L
A
R
P
T
R
L
S
L
G
D
P
K
A
S
Site 168
S869
S
L
G
D
P
K
A
S
T
L
P
R
A
R
E
Site 169
T870
L
G
D
P
K
A
S
T
L
P
R
A
R
E
Q
Site 170
S892
L
H
P
P
E
P
K
S
P
G
E
Y
V
N
I
Site 171
Y896
E
P
K
S
P
G
E
Y
V
N
I
E
F
G
S
Site 172
S906
I
E
F
G
S
D
Q
S
G
Y
L
S
G
P
V
Site 173
Y908
F
G
S
D
Q
S
G
Y
L
S
G
P
V
A
F
Site 174
S910
S
D
Q
S
G
Y
L
S
G
P
V
A
F
H
S
Site 175
S917
S
G
P
V
A
F
H
S
S
P
S
V
R
C
P
Site 176
S918
G
P
V
A
F
H
S
S
P
S
V
R
C
P
S
Site 177
S920
V
A
F
H
S
S
P
S
V
R
C
P
S
Q
L
Site 178
S925
S
P
S
V
R
C
P
S
Q
L
Q
P
A
P
R
Site 179
T938
P
R
E
E
E
T
G
T
E
E
Y
M
K
M
D
Site 180
Y941
E
E
T
G
T
E
E
Y
M
K
M
D
L
G
P
Site 181
S957
R
R
A
A
W
Q
E
S
T
G
V
E
M
G
R
Site 182
S974
P
A
P
P
G
A
A
S
I
C
R
P
T
R
A
Site 183
T979
A
A
S
I
C
R
P
T
R
A
V
P
S
S
R
Site 184
S984
R
P
T
R
A
V
P
S
S
R
G
D
Y
M
T
Site 185
S985
P
T
R
A
V
P
S
S
R
G
D
Y
M
T
M
Site 186
Y989
V
P
S
S
R
G
D
Y
M
T
M
Q
M
S
C
Site 187
T991
S
S
R
G
D
Y
M
T
M
Q
M
S
C
P
R
Site 188
S1000
Q
M
S
C
P
R
Q
S
Y
V
D
T
S
P
A
Site 189
Y1001
M
S
C
P
R
Q
S
Y
V
D
T
S
P
A
A
Site 190
T1004
P
R
Q
S
Y
V
D
T
S
P
A
A
P
V
S
Site 191
S1005
R
Q
S
Y
V
D
T
S
P
A
A
P
V
S
Y
Site 192
S1011
T
S
P
A
A
P
V
S
Y
A
D
M
R
T
G
Site 193
Y1012
S
P
A
A
P
V
S
Y
A
D
M
R
T
G
I
Site 194
T1030
E
V
S
L
P
R
A
T
M
A
A
A
S
S
S
Site 195
S1041
A
S
S
S
S
A
A
S
A
S
P
T
G
P
Q
Site 196
S1043
S
S
S
A
A
S
A
S
P
T
G
P
Q
G
A
Site 197
T1045
S
A
A
S
A
S
P
T
G
P
Q
G
A
A
E
Site 198
T1073
P
G
G
M
S
A
F
T
R
V
N
L
S
P
N
Site 199
S1078
A
F
T
R
V
N
L
S
P
N
R
N
Q
S
A
Site 200
S1084
L
S
P
N
R
N
Q
S
A
K
V
I
R
A
D
Site 201
S1100
Q
G
C
R
R
R
H
S
S
E
T
F
S
S
T
Site 202
S1101
G
C
R
R
R
H
S
S
E
T
F
S
S
T
P
Site 203
T1103
R
R
R
H
S
S
E
T
F
S
S
T
P
S
A
Site 204
S1105
R
H
S
S
E
T
F
S
S
T
P
S
A
T
R
Site 205
S1106
H
S
S
E
T
F
S
S
T
P
S
A
T
R
V
Site 206
T1107
S
S
E
T
F
S
S
T
P
S
A
T
R
V
G
Site 207
S1109
E
T
F
S
S
T
P
S
A
T
R
V
G
N
T
Site 208
T1111
F
S
S
T
P
S
A
T
R
V
G
N
T
V
P
Site 209
S1131
A
V
G
G
G
G
G
S
S
S
S
S
E
D
V
Site 210
S1132
V
G
G
G
G
G
S
S
S
S
S
E
D
V
K
Site 211
S1133
G
G
G
G
G
S
S
S
S
S
E
D
V
K
R
Site 212
S1134
G
G
G
G
S
S
S
S
S
E
D
V
K
R
H
Site 213
S1135
G
G
G
S
S
S
S
S
E
D
V
K
R
H
S
Site 214
S1142
S
E
D
V
K
R
H
S
S
A
S
F
E
N
V
Site 215
S1143
E
D
V
K
R
H
S
S
A
S
F
E
N
V
W
Site 216
S1145
V
K
R
H
S
S
A
S
F
E
N
V
W
L
R
Site 217
Y1179
G
L
E
N
G
L
N
Y
I
D
L
D
L
V
K
Site 218
T1196
K
Q
C
P
Q
E
C
T
P
E
P
Q
P
P
P
Site 219
S1213
P
P
H
Q
P
L
G
S
G
E
S
S
S
T
R
Site 220
S1216
Q
P
L
G
S
G
E
S
S
S
T
R
R
S
S
Site 221
S1217
P
L
G
S
G
E
S
S
S
T
R
R
S
S
E
Site 222
S1218
L
G
S
G
E
S
S
S
T
R
R
S
S
E
D
Site 223
T1219
G
S
G
E
S
S
S
T
R
R
S
S
E
D
L
Site 224
S1222
E
S
S
S
T
R
R
S
S
E
D
L
S
A
Y
Site 225
S1223
S
S
S
T
R
R
S
S
E
D
L
S
A
Y
A
Site 226
S1227
R
R
S
S
E
D
L
S
A
Y
A
S
I
S
F
Site 227
Y1229
S
S
E
D
L
S
A
Y
A
S
I
S
F
Q
K
Site 228
S1231
E
D
L
S
A
Y
A
S
I
S
F
Q
K
Q
P
Site 229
S1233
L
S
A
Y
A
S
I
S
F
Q
K
Q
P
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation