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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADD1
Full Name:
Alpha-adducin
Alias:
ADDA; adducin 1 (alpha); adducin, alpha; Alpha adducin; Erythrocyte adducin alpha subunit
Type:
Cytoskeletal protein
Mass (Da):
80960
Number AA:
737
UniProt ID:
P35611
International Prot ID:
IPI00019901
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008290
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0005516
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
GO:0051017
GO:0051016
GO:0032092
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
D
S
R
A
A
V
V
T
S
P
P
P
T
T
A
Site 2
S12
S
R
A
A
V
V
T
S
P
P
P
T
T
A
P
Site 3
T16
V
V
T
S
P
P
P
T
T
A
P
H
K
E
R
Site 4
T17
V
T
S
P
P
P
T
T
A
P
H
K
E
R
Y
Site 5
Y24
T
A
P
H
K
E
R
Y
F
D
R
V
D
E
N
Site 6
Y35
V
D
E
N
N
P
E
Y
L
R
E
R
N
M
A
Site 7
S59
M
E
Q
K
K
R
V
S
M
I
L
Q
S
P
A
Site 8
S64
R
V
S
M
I
L
Q
S
P
A
F
C
E
E
L
Site 9
Y106
T
T
N
V
P
N
V
Y
P
A
A
P
Q
G
G
Site 10
T125
N
M
S
L
G
M
V
T
P
V
N
D
L
R
G
Site 11
S133
P
V
N
D
L
R
G
S
D
S
I
A
Y
D
K
Site 12
S135
N
D
L
R
G
S
D
S
I
A
Y
D
K
G
E
Site 13
Y138
R
G
S
D
S
I
A
Y
D
K
G
E
K
L
L
Site 14
Y166
F
G
W
S
Q
L
I
Y
N
H
I
T
T
R
V
Site 15
S175
H
I
T
T
R
V
N
S
E
Q
E
H
F
L
I
Site 16
S211
G
D
I
V
D
R
G
S
T
N
L
G
V
N
Q
Site 17
T212
D
I
V
D
R
G
S
T
N
L
G
V
N
Q
A
Site 18
Y273
G
E
V
A
Y
H
D
Y
H
G
I
L
V
D
E
Site 19
S294
Q
K
N
L
G
P
K
S
K
V
L
I
L
R
N
Site 20
S306
L
R
N
H
G
L
V
S
V
G
E
S
V
E
E
Site 21
T331
A
C
E
I
Q
V
R
T
L
A
S
A
G
G
P
Site 22
S334
I
Q
V
R
T
L
A
S
A
G
G
P
D
N
L
Site 23
Y349
V
L
L
N
P
E
K
Y
K
A
K
S
R
S
P
Site 24
S353
P
E
K
Y
K
A
K
S
R
S
P
G
S
P
V
Site 25
S355
K
Y
K
A
K
S
R
S
P
G
S
P
V
G
E
Site 26
S358
A
K
S
R
S
P
G
S
P
V
G
E
G
T
G
Site 27
T364
G
S
P
V
G
E
G
T
G
S
P
P
K
W
Q
Site 28
S366
P
V
G
E
G
T
G
S
P
P
K
W
Q
I
G
Site 29
Y389
R
M
L
D
N
L
G
Y
R
T
G
Y
P
Y
R
Site 30
Y393
N
L
G
Y
R
T
G
Y
P
Y
R
Y
P
A
L
Site 31
Y395
G
Y
R
T
G
Y
P
Y
R
Y
P
A
L
R
E
Site 32
Y397
R
T
G
Y
P
Y
R
Y
P
A
L
R
E
K
S
Site 33
S404
Y
P
A
L
R
E
K
S
K
K
Y
S
D
V
E
Site 34
S408
R
E
K
S
K
K
Y
S
D
V
E
V
P
A
S
Site 35
S415
S
D
V
E
V
P
A
S
V
T
G
Y
S
F
A
Site 36
T417
V
E
V
P
A
S
V
T
G
Y
S
F
A
S
D
Site 37
Y419
V
P
A
S
V
T
G
Y
S
F
A
S
D
G
D
Site 38
S420
P
A
S
V
T
G
Y
S
F
A
S
D
G
D
S
Site 39
S423
V
T
G
Y
S
F
A
S
D
G
D
S
G
T
C
Site 40
S427
S
F
A
S
D
G
D
S
G
T
C
S
P
L
R
Site 41
T429
A
S
D
G
D
S
G
T
C
S
P
L
R
H
S
Site 42
S431
D
G
D
S
G
T
C
S
P
L
R
H
S
F
Q
Site 43
S436
T
C
S
P
L
R
H
S
F
Q
K
Q
Q
R
E
Site 44
T445
Q
K
Q
Q
R
E
K
T
R
W
L
N
S
G
R
Site 45
S450
E
K
T
R
W
L
N
S
G
R
G
D
E
A
S
Site 46
S457
S
G
R
G
D
E
A
S
E
E
G
Q
N
G
S
Site 47
S464
S
E
E
G
Q
N
G
S
S
P
K
S
K
T
K
Site 48
S465
E
E
G
Q
N
G
S
S
P
K
S
K
T
K
W
Site 49
S468
Q
N
G
S
S
P
K
S
K
T
K
W
T
K
E
Site 50
T470
G
S
S
P
K
S
K
T
K
W
T
K
E
D
G
Site 51
T480
T
K
E
D
G
H
R
T
S
T
S
A
V
P
N
Site 52
S481
K
E
D
G
H
R
T
S
T
S
A
V
P
N
L
Site 53
T482
E
D
G
H
R
T
S
T
S
A
V
P
N
L
F
Site 54
S483
D
G
H
R
T
S
T
S
A
V
P
N
L
F
V
Site 55
T516
Q
N
L
Q
D
I
K
T
A
G
P
Q
S
Q
V
Site 56
S532
C
G
V
V
M
D
R
S
L
V
Q
G
E
L
V
Site 57
Y550
K
A
I
I
E
K
E
Y
Q
P
H
V
I
V
S
Site 58
T558
Q
P
H
V
I
V
S
T
T
G
P
N
P
F
T
Site 59
T559
P
H
V
I
V
S
T
T
G
P
N
P
F
T
T
Site 60
T566
T
G
P
N
P
F
T
T
L
T
D
R
E
L
E
Site 61
T568
P
N
P
F
T
T
L
T
D
R
E
L
E
E
Y
Site 62
Y575
T
D
R
E
L
E
E
Y
R
R
E
V
E
R
K
Site 63
S586
V
E
R
K
Q
K
G
S
E
E
N
L
D
E
A
Site 64
S600
A
R
E
Q
K
E
K
S
P
P
D
Q
P
A
V
Site 65
S613
A
V
P
H
P
P
P
S
T
P
I
K
L
E
E
Site 66
T614
V
P
H
P
P
P
S
T
P
I
K
L
E
E
D
Site 67
T627
E
D
L
V
P
E
P
T
T
G
D
D
S
D
A
Site 68
T628
D
L
V
P
E
P
T
T
G
D
D
S
D
A
A
Site 69
S632
E
P
T
T
G
D
D
S
D
A
A
T
F
K
P
Site 70
T636
G
D
D
S
D
A
A
T
F
K
P
T
L
P
D
Site 71
S645
K
P
T
L
P
D
L
S
P
D
E
P
S
E
A
Site 72
S650
D
L
S
P
D
E
P
S
E
A
L
G
F
P
M
Site 73
S669
E
E
A
H
R
P
P
S
P
T
E
A
P
T
E
Site 74
T671
A
H
R
P
P
S
P
T
E
A
P
T
E
A
S
Site 75
T675
P
S
P
T
E
A
P
T
E
A
S
P
E
P
A
Site 76
S678
T
E
A
P
T
E
A
S
P
E
P
A
P
D
P
Site 77
S707
G
A
A
A
D
P
G
S
D
G
S
P
G
K
S
Site 78
S710
A
D
P
G
S
D
G
S
P
G
K
S
P
S
K
Site 79
S714
S
D
G
S
P
G
K
S
P
S
K
K
K
K
K
Site 80
S716
G
S
P
G
K
S
P
S
K
K
K
K
K
F
R
Site 81
T724
K
K
K
K
K
F
R
T
P
S
F
L
K
K
S
Site 82
S726
K
K
K
F
R
T
P
S
F
L
K
K
S
K
K
Site 83
S731
T
P
S
F
L
K
K
S
K
K
K
S
D
S
_
Site 84
S735
L
K
K
S
K
K
K
S
D
S
_
_
_
_
_
Site 85
S737
K
S
K
K
K
S
D
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation