KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ADD2
Full Name:
Beta-adducin
Alias:
Add97; ADDB; Adducin 2 (beta); Adducin 63; Adducin, beta; Beta adducin; Erythrocyte adducin beta subunit; Erythrocyte adducin subunit beta
Type:
Cytoskeletal protein
Mass (Da):
80854
Number AA:
726
UniProt ID:
P35612
International Prot ID:
IPI00019904
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008290
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0005516
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
GO:0051017
GO:0051016
GO:0032092
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
S
E
E
T
V
P
E
A
A
S
P
Site 2
S11
E
T
V
P
E
A
A
S
P
P
P
P
Q
G
Q
Site 3
Y20
P
P
P
Q
G
Q
P
Y
F
D
R
F
S
E
D
Site 4
S25
Q
P
Y
F
D
R
F
S
E
D
D
P
E
Y
M
Site 5
Y31
F
S
E
D
D
P
E
Y
M
R
L
R
N
R
A
Site 6
T55
M
E
Q
K
K
R
V
T
M
I
L
Q
S
P
S
Site 7
S60
R
V
T
M
I
L
Q
S
P
S
F
R
E
E
L
Site 8
S62
T
M
I
L
Q
S
P
S
F
R
E
E
L
E
G
Site 9
S81
Q
M
K
K
G
N
N
S
S
N
I
W
A
L
R
Site 10
S110
P
T
S
S
M
N
V
S
M
M
T
P
I
N
D
Site 11
T113
S
M
N
V
S
M
M
T
P
I
N
D
L
H
T
Site 12
S123
N
D
L
H
T
A
D
S
L
N
L
A
K
G
E
Site 13
S153
L
Y
G
W
A
Q
L
S
D
T
Y
V
T
L
R
Site 14
T155
G
W
A
Q
L
S
D
T
Y
V
T
L
R
V
S
Site 15
Y156
W
A
Q
L
S
D
T
Y
V
T
L
R
V
S
K
Site 16
T158
Q
L
S
D
T
Y
V
T
L
R
V
S
K
E
Q
Site 17
S162
T
Y
V
T
L
R
V
S
K
E
Q
D
H
F
L
Site 18
S171
E
Q
D
H
F
L
I
S
P
K
G
V
S
C
S
Site 19
S178
S
P
K
G
V
S
C
S
E
V
T
A
S
S
L
Site 20
S200
E
V
V
E
K
G
S
S
C
F
P
V
D
T
T
Site 21
Y259
L
V
G
D
M
A
Y
Y
D
F
N
G
E
M
E
Site 22
Y304
D
T
V
E
E
A
F
Y
K
I
F
H
L
Q
A
Site 23
S344
H
R
P
H
E
V
G
S
V
Q
W
A
G
S
T
Site 24
T351
S
V
Q
W
A
G
S
T
F
G
P
M
Q
K
S
Site 25
S358
T
F
G
P
M
Q
K
S
R
L
G
E
H
E
F
Site 26
Y377
R
M
L
D
N
L
G
Y
R
T
G
Y
T
Y
R
Site 27
Y381
N
L
G
Y
R
T
G
Y
T
Y
R
H
P
F
V
Site 28
T382
L
G
Y
R
T
G
Y
T
Y
R
H
P
F
V
Q
Site 29
Y383
G
Y
R
T
G
Y
T
Y
R
H
P
F
V
Q
E
Site 30
S396
Q
E
K
T
K
H
K
S
E
V
E
I
P
A
T
Site 31
T436
E
K
T
R
W
L
N
T
P
N
T
Y
L
R
V
Site 32
T439
R
W
L
N
T
P
N
T
Y
L
R
V
N
V
A
Site 33
Y440
W
L
N
T
P
N
T
Y
L
R
V
N
V
A
D
Site 34
S452
V
A
D
E
V
Q
R
S
M
G
S
P
R
P
K
Site 35
S455
E
V
Q
R
S
M
G
S
P
R
P
K
T
T
W
Site 36
T460
M
G
S
P
R
P
K
T
T
W
M
K
A
D
E
Site 37
S471
K
A
D
E
V
E
K
S
S
S
G
M
P
I
R
Site 38
S473
D
E
V
E
K
S
S
S
G
M
P
I
R
I
E
Site 39
Y489
P
N
Q
F
V
P
L
Y
T
D
P
Q
E
V
L
Site 40
S512
Q
N
R
Q
D
V
K
S
A
G
P
Q
S
Q
L
Site 41
S528
A
S
V
I
A
E
K
S
R
S
P
S
T
E
S
Site 42
S530
V
I
A
E
K
S
R
S
P
S
T
E
S
Q
L
Site 43
S532
A
E
K
S
R
S
P
S
T
E
S
Q
L
M
S
Site 44
T533
E
K
S
R
S
P
S
T
E
S
Q
L
M
S
K
Site 45
S535
S
R
S
P
S
T
E
S
Q
L
M
S
K
G
D
Site 46
S539
S
T
E
S
Q
L
M
S
K
G
D
E
D
T
K
Site 47
T545
M
S
K
G
D
E
D
T
K
D
D
S
E
E
T
Site 48
S549
D
E
D
T
K
D
D
S
E
E
T
V
P
N
P
Site 49
S558
E
T
V
P
N
P
F
S
Q
L
T
D
Q
E
L
Site 50
Y568
T
D
Q
E
L
E
E
Y
K
K
E
V
E
R
K
Site 51
T585
E
L
D
G
E
K
E
T
A
P
E
E
P
G
S
Site 52
S592
T
A
P
E
E
P
G
S
P
A
K
S
A
P
A
Site 53
S596
E
P
G
S
P
A
K
S
A
P
A
S
P
V
Q
Site 54
S600
P
A
K
S
A
P
A
S
P
V
Q
S
P
A
K
Site 55
S604
A
P
A
S
P
V
Q
S
P
A
K
E
A
E
T
Site 56
T611
S
P
A
K
E
A
E
T
K
S
P
L
V
S
P
Site 57
S613
A
K
E
A
E
T
K
S
P
L
V
S
P
S
K
Site 58
S617
E
T
K
S
P
L
V
S
P
S
K
S
L
E
E
Site 59
S619
K
S
P
L
V
S
P
S
K
S
L
E
E
G
T
Site 60
S621
P
L
V
S
P
S
K
S
L
E
E
G
T
K
K
Site 61
T626
S
K
S
L
E
E
G
T
K
K
T
E
T
S
K
Site 62
T636
T
E
T
S
K
A
A
T
T
E
P
E
T
T
Q
Site 63
T641
A
A
T
T
E
P
E
T
T
Q
P
E
G
V
V
Site 64
T642
A
T
T
E
P
E
T
T
Q
P
E
G
V
V
V
Site 65
T657
N
G
R
E
E
E
Q
T
A
E
E
I
L
S
K
Site 66
S663
Q
T
A
E
E
I
L
S
K
G
L
S
Q
M
T
Site 67
S667
E
I
L
S
K
G
L
S
Q
M
T
T
S
A
D
Site 68
T671
K
G
L
S
Q
M
T
T
S
A
D
T
D
V
D
Site 69
T679
S
A
D
T
D
V
D
T
S
K
D
K
T
E
S
Site 70
T684
V
D
T
S
K
D
K
T
E
S
V
T
S
G
P
Site 71
S686
T
S
K
D
K
T
E
S
V
T
S
G
P
M
S
Site 72
T688
K
D
K
T
E
S
V
T
S
G
P
M
S
P
E
Site 73
S689
D
K
T
E
S
V
T
S
G
P
M
S
P
E
G
Site 74
S693
S
V
T
S
G
P
M
S
P
E
G
S
P
S
K
Site 75
S697
G
P
M
S
P
E
G
S
P
S
K
S
P
S
K
Site 76
S699
M
S
P
E
G
S
P
S
K
S
P
S
K
K
K
Site 77
S701
P
E
G
S
P
S
K
S
P
S
K
K
K
K
K
Site 78
S703
G
S
P
S
K
S
P
S
K
K
K
K
K
F
R
Site 79
T711
K
K
K
K
K
F
R
T
P
S
F
L
K
K
S
Site 80
S713
K
K
K
F
R
T
P
S
F
L
K
K
S
K
K
Site 81
S718
T
P
S
F
L
K
K
S
K
K
K
E
K
V
E
Site 82
S726
K
K
K
E
K
V
E
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation