KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MYH11
Full Name:
Myosin-11
Alias:
Myosin heavy chain, smooth muscle isoform; Myosin, heavy chain 11, smooth muscle; Myosin, heavy polypeptide 11, smooth muscle; SMHC; SMMHC
Type:
Motor protein
Mass (Da):
227339
Number AA:
1972
UniProt ID:
P35749
International Prot ID:
IPI00020501
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042470
GO:0005859
GO:0032982
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0048739
GO:0048251
GO:0030241
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
Q
K
G
Q
L
S
D
D
E
K
F
L
F
Site 2
S23
V
D
K
N
F
I
N
S
P
V
A
Q
A
D
W
Site 3
S40
K
R
L
V
W
V
P
S
E
K
Q
G
F
E
A
Site 4
Y109
L
H
N
L
R
E
R
Y
F
S
G
L
I
Y
T
Site 5
S111
N
L
R
E
R
Y
F
S
G
L
I
Y
T
Y
S
Site 6
Y134
P
Y
K
H
L
P
I
Y
S
E
K
I
V
D
M
Site 7
Y142
S
E
K
I
V
D
M
Y
K
G
K
K
R
H
E
Site 8
Y155
H
E
M
P
P
H
I
Y
A
I
A
D
T
A
Y
Site 9
Y162
Y
A
I
A
D
T
A
Y
R
S
M
L
Q
D
R
Site 10
S173
L
Q
D
R
E
D
Q
S
I
L
C
T
G
E
S
Site 11
T177
E
D
Q
S
I
L
C
T
G
E
S
G
A
G
K
Site 12
S180
S
I
L
C
T
G
E
S
G
A
G
K
T
E
N
Site 13
T185
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Site 14
T188
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
Site 15
Y194
N
T
K
K
V
I
Q
Y
L
A
V
V
A
S
S
Site 16
S200
Q
Y
L
A
V
V
A
S
S
H
K
G
K
K
D
Site 17
S209
H
K
G
K
K
D
T
S
I
T
G
E
L
E
K
Site 18
T233
E
A
F
G
N
A
K
T
V
K
N
D
N
S
S
Site 19
S239
K
T
V
K
N
D
N
S
S
R
F
G
K
F
I
Site 20
S240
T
V
K
N
D
N
S
S
R
F
G
K
F
I
R
Site 21
Y264
V
G
A
N
I
E
T
Y
L
L
E
K
S
R
A
Site 22
S269
E
T
Y
L
L
E
K
S
R
A
I
R
Q
A
R
Site 23
Y285
E
R
T
F
H
I
F
Y
Y
M
I
A
G
A
K
Site 24
S297
G
A
K
E
K
M
R
S
D
L
L
L
E
G
F
Site 25
S345
F
S
E
E
E
Q
L
S
I
L
K
V
V
S
S
Site 26
T367
V
F
K
K
E
R
N
T
D
Q
A
S
M
P
D
Site 27
S371
E
R
N
T
D
Q
A
S
M
P
D
N
T
A
A
Site 28
T393
G
I
N
V
T
D
F
T
R
S
I
L
T
P
R
Site 29
T398
D
F
T
R
S
I
L
T
P
R
I
K
V
G
R
Site 30
Y429
E
A
L
A
K
A
T
Y
E
R
L
F
R
W
I
Site 31
T447
V
N
K
A
L
D
K
T
H
R
Q
G
A
S
F
Site 32
S453
K
T
H
R
Q
G
A
S
F
L
G
I
L
D
I
Site 33
T479
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
L
Site 34
Y499
F
I
L
E
Q
E
E
Y
Q
R
E
G
I
E
W
Site 35
S548
F
P
K
A
T
D
K
S
F
V
E
K
L
C
T
Site 36
T555
S
F
V
E
K
L
C
T
E
Q
G
S
H
P
K
Site 37
T573
P
K
Q
L
K
D
K
T
E
F
S
I
I
H
Y
Site 38
Y580
T
E
F
S
I
I
H
Y
A
G
K
V
D
Y
N
Site 39
Y586
H
Y
A
G
K
V
D
Y
N
A
S
A
W
L
T
Site 40
S605
P
L
N
D
N
V
T
S
L
L
N
A
S
S
D
Site 41
T635
L
D
Q
M
A
K
M
T
E
S
S
L
P
S
A
Site 42
S637
Q
M
A
K
M
T
E
S
S
L
P
S
A
S
K
Site 43
S638
M
A
K
M
T
E
S
S
L
P
S
A
S
K
T
Site 44
S641
M
T
E
S
S
L
P
S
A
S
K
T
K
K
G
Site 45
S643
E
S
S
L
P
S
A
S
K
T
K
K
G
M
F
Site 46
T645
S
L
P
S
A
S
K
T
K
K
G
M
F
R
T
Site 47
Y657
F
R
T
V
G
Q
L
Y
K
E
Q
L
G
K
L
Site 48
T666
E
Q
L
G
K
L
M
T
T
L
R
N
T
T
P
Site 49
T667
Q
L
G
K
L
M
T
T
L
R
N
T
T
P
N
Site 50
T671
L
M
T
T
L
R
N
T
T
P
N
F
V
R
C
Site 51
T672
M
T
T
L
R
N
T
T
P
N
F
V
R
C
I
Site 52
Y728
F
Q
E
F
R
Q
R
Y
E
I
L
A
A
N
A
Site 53
Y761
L
E
L
D
P
N
L
Y
R
I
G
Q
S
K
I
Site 54
S766
N
L
Y
R
I
G
Q
S
K
I
F
F
R
T
G
Site 55
T787
E
E
R
D
L
K
I
T
D
V
I
M
A
F
Q
Site 56
T814
A
K
R
Q
Q
Q
L
T
A
M
K
V
I
Q
R
Site 57
Y826
I
Q
R
N
C
A
A
Y
L
K
L
R
N
W
Q
Site 58
T864
K
E
D
E
L
Q
K
T
K
E
R
Q
Q
K
A
Site 59
S883
K
E
L
E
Q
K
H
S
Q
L
T
E
E
K
N
Site 60
T900
Q
E
Q
L
Q
A
E
T
E
L
Y
A
E
A
E
Site 61
Y903
L
Q
A
E
T
E
L
Y
A
E
A
E
E
M
R
Site 62
S998
D
D
Q
N
N
K
L
S
K
E
R
K
L
L
E
Site 63
S1009
K
L
L
E
E
R
I
S
D
L
T
T
N
L
A
Site 64
T1012
E
E
R
I
S
D
L
T
T
N
L
A
E
E
E
Site 65
T1013
E
R
I
S
D
L
T
T
N
L
A
E
E
E
E
Site 66
S1034
K
L
K
N
K
H
E
S
M
I
S
E
L
E
V
Site 67
S1049
R
L
K
K
E
E
K
S
R
Q
E
L
E
K
L
Site 68
S1065
R
K
L
E
G
D
A
S
D
F
H
E
Q
I
A
Site 69
S1121
R
E
L
E
G
H
I
S
D
L
Q
E
D
L
D
Site 70
S1129
D
L
Q
E
D
L
D
S
E
R
A
A
R
N
K
Site 71
T1153
E
E
L
E
A
L
K
T
E
L
E
D
T
L
D
Site 72
T1158
L
K
T
E
L
E
D
T
L
D
S
T
A
T
Q
Site 73
S1161
E
L
E
D
T
L
D
S
T
A
T
Q
Q
E
L
Site 74
T1162
L
E
D
T
L
D
S
T
A
T
Q
Q
E
L
R
Site 75
T1177
A
K
R
E
Q
E
V
T
V
L
K
K
A
L
D
Site 76
S1189
A
L
D
E
E
T
R
S
H
E
A
Q
V
Q
E
Site 77
S1291
K
L
Q
N
E
V
E
S
V
T
G
M
L
N
E
Site 78
S1312
K
L
A
K
D
V
A
S
L
S
S
Q
L
Q
D
Site 79
S1347
Q
L
E
E
E
R
N
S
L
Q
D
Q
L
D
E
Site 80
S1367
Q
N
L
E
R
H
I
S
T
L
N
I
Q
L
S
Site 81
T1368
N
L
E
R
H
I
S
T
L
N
I
Q
L
S
D
Site 82
S1374
S
T
L
N
I
Q
L
S
D
S
K
K
K
L
Q
Site 83
S1376
L
N
I
Q
L
S
D
S
K
K
K
L
Q
D
F
Site 84
S1385
K
K
L
Q
D
F
A
S
T
V
E
A
L
E
E
Site 85
T1405
Q
K
E
I
E
N
L
T
Q
Q
Y
E
E
K
A
Site 86
Y1408
I
E
N
L
T
Q
Q
Y
E
E
K
A
A
A
Y
Site 87
Y1415
Y
E
E
K
A
A
A
Y
D
K
L
E
K
T
K
Site 88
T1421
A
Y
D
K
L
E
K
T
K
N
R
L
Q
Q
E
Site 89
S1444
D
N
Q
R
Q
L
V
S
N
L
E
K
K
Q
R
Site 90
S1465
A
E
E
K
N
I
S
S
K
Y
A
D
E
R
D
Site 91
Y1467
E
K
N
I
S
S
K
Y
A
D
E
R
D
R
A
Site 92
S1487
E
K
E
T
K
A
L
S
L
A
R
A
L
E
E
Site 93
T1505
A
K
E
E
L
E
R
T
N
K
M
L
K
A
E
Site 94
S1518
A
E
M
E
D
L
V
S
S
K
D
D
V
G
K
Site 95
S1533
N
V
H
E
L
E
K
S
K
R
A
L
E
T
Q
Site 96
T1539
K
S
K
R
A
L
E
T
Q
M
E
E
M
K
T
Site 97
T1546
T
Q
M
E
E
M
K
T
Q
L
E
E
L
E
D
Site 98
T1558
L
E
D
E
L
Q
A
T
E
D
A
K
L
R
L
Site 99
Y1601
L
Q
R
Q
L
H
E
Y
E
T
E
L
E
D
E
Site 100
S1667
E
L
E
D
A
R
A
S
R
D
E
I
F
A
T
Site 101
T1674
S
R
D
E
I
F
A
T
A
K
E
N
E
K
K
Site 102
S1684
E
N
E
K
K
A
K
S
L
E
A
D
L
M
Q
Site 103
S1720
L
A
E
E
L
A
S
S
L
S
G
R
N
A
L
Site 104
S1722
E
E
L
A
S
S
L
S
G
R
N
A
L
Q
D
Site 105
S1756
Q
G
N
M
E
A
M
S
D
R
V
R
K
A
T
Site 106
T1763
S
D
R
V
R
K
A
T
Q
Q
A
E
Q
L
S
Site 107
S1770
T
Q
Q
A
E
Q
L
S
N
E
L
A
T
E
R
Site 108
S1778
N
E
L
A
T
E
R
S
T
A
Q
K
N
E
S
Site 109
T1779
E
L
A
T
E
R
S
T
A
Q
K
N
E
S
A
Site 110
S1785
S
T
A
Q
K
N
E
S
A
R
Q
Q
L
E
R
Site 111
S1810
E
M
E
G
A
V
K
S
K
F
K
S
T
I
A
Site 112
S1814
A
V
K
S
K
F
K
S
T
I
A
A
L
E
A
Site 113
T1815
V
K
S
K
F
K
S
T
I
A
A
L
E
A
K
Site 114
S1843
E
K
Q
A
A
T
K
S
L
K
Q
K
D
K
K
Site 115
Y1868
E
R
K
M
A
E
Q
Y
K
E
Q
A
E
K
G
Site 116
S1893
L
E
E
A
E
E
E
S
Q
R
I
N
A
N
R
Site 117
S1913
E
L
D
E
A
T
E
S
N
E
A
M
G
R
E
Site 118
S1926
R
E
V
N
A
L
K
S
K
L
R
R
G
N
E
Site 119
T1934
K
L
R
R
G
N
E
T
S
F
V
P
S
R
R
Site 120
S1935
L
R
R
G
N
E
T
S
F
V
P
S
R
R
S
Site 121
S1939
N
E
T
S
F
V
P
S
R
R
S
G
G
R
R
Site 122
S1942
S
F
V
P
S
R
R
S
G
G
R
R
V
I
E
Site 123
S1954
V
I
E
N
A
D
G
S
E
E
E
T
D
T
R
Site 124
T1958
A
D
G
S
E
E
E
T
D
T
R
D
A
D
F
Site 125
T1960
G
S
E
E
E
T
D
T
R
D
A
D
F
N
G
Site 126
S1971
D
F
N
G
T
K
A
S
E
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation