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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PEDF
Full Name:
Pigment epithelium-derived factor
Alias:
Cell proliferation-inducing gene 35 protein; EPC-1; PIG35; Pigment epithelium-derived factor; Proliferation-inducing protein 35; Serine (or cysteine) proteinase inhibitor clade F (alpha-2 antiplasmin, pigment epithelium derived factor) member 1; Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor) member 1; SERPINF1; Serpin-F1
Type:
Inhibitor protein; Secreted protein
Mass (Da):
46342
Number AA:
418
UniProt ID:
P36955
International Prot ID:
IPI00006114
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0016525
GO:0050769
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
G
A
L
L
G
H
S
S
C
Q
N
P
A
S
P
Site 2
S24
S
S
C
Q
N
P
A
S
P
P
E
E
G
S
P
Site 3
S30
A
S
P
P
E
E
G
S
P
D
P
D
S
T
G
Site 4
S35
E
G
S
P
D
P
D
S
T
G
A
L
V
E
E
Site 5
Y63
A
A
V
S
N
F
G
Y
D
L
Y
R
V
R
S
Site 6
Y66
S
N
F
G
Y
D
L
Y
R
V
R
S
S
M
S
Site 7
S70
Y
D
L
Y
R
V
R
S
S
M
S
P
T
T
N
Site 8
S71
D
L
Y
R
V
R
S
S
M
S
P
T
T
N
V
Site 9
S73
Y
R
V
R
S
S
M
S
P
T
T
N
V
L
L
Site 10
T75
V
R
S
S
M
S
P
T
T
N
V
L
L
S
P
Site 11
T76
R
S
S
M
S
P
T
T
N
V
L
L
S
P
L
Site 12
S102
G
A
E
Q
R
T
E
S
I
I
H
R
A
L
Y
Site 13
S114
A
L
Y
Y
D
L
I
S
S
P
D
I
H
G
T
Site 14
S115
L
Y
Y
D
L
I
S
S
P
D
I
H
G
T
Y
Site 15
T128
T
Y
K
E
L
L
D
T
V
T
A
P
Q
K
N
Site 16
T130
K
E
L
L
D
T
V
T
A
P
Q
K
N
L
K
Site 17
S138
A
P
Q
K
N
L
K
S
A
S
R
I
V
F
E
Site 18
S152
E
K
K
L
R
I
K
S
S
F
V
A
P
L
E
Site 19
S153
K
K
L
R
I
K
S
S
F
V
A
P
L
E
K
Site 20
S161
F
V
A
P
L
E
K
S
Y
G
T
R
P
R
V
Site 21
T170
G
T
R
P
R
V
L
T
G
N
P
R
L
D
L
Site 22
S195
M
K
G
K
L
A
R
S
T
K
E
I
P
D
E
Site 23
T196
K
G
K
L
A
R
S
T
K
E
I
P
D
E
I
Site 24
S223
Q
W
V
T
K
F
D
S
R
K
T
S
L
E
D
Site 25
T226
T
K
F
D
S
R
K
T
S
L
E
D
F
Y
L
Site 26
S227
K
F
D
S
R
K
T
S
L
E
D
F
Y
L
D
Site 27
Y232
K
T
S
L
E
D
F
Y
L
D
E
E
R
T
V
Site 28
T238
F
Y
L
D
E
E
R
T
V
R
V
P
M
M
S
Site 29
S245
T
V
R
V
P
M
M
S
D
P
K
A
V
L
R
Site 30
S260
Y
G
L
D
S
D
L
S
C
K
I
A
Q
L
P
Site 31
S295
L
I
E
E
S
L
T
S
E
F
I
H
D
I
D
Site 32
S320
T
V
P
K
L
K
L
S
Y
E
G
E
V
T
K
Site 33
T326
L
S
Y
E
G
E
V
T
K
S
L
Q
E
M
K
Site 34
S328
Y
E
G
E
V
T
K
S
L
Q
E
M
K
L
Q
Site 35
S336
L
Q
E
M
K
L
Q
S
L
F
D
S
P
D
F
Site 36
S340
K
L
Q
S
L
F
D
S
P
D
F
S
K
I
T
Site 37
S344
L
F
D
S
P
D
F
S
K
I
T
G
K
P
I
Site 38
T347
S
P
D
F
S
K
I
T
G
K
P
I
K
L
T
Site 39
T354
T
G
K
P
I
K
L
T
Q
V
E
H
R
A
G
Site 40
T372
N
E
D
G
A
G
T
T
P
S
P
G
L
Q
P
Site 41
S374
D
G
A
G
T
T
P
S
P
G
L
Q
P
A
H
Site 42
Y388
H
L
T
F
P
L
D
Y
H
L
N
Q
P
F
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation