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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
COIL
Full Name:
Coilin
Alias:
CLN80; P80; P80C; P80-coilin
Type:
Oxidoreductase
Mass (Da):
62608
Number AA:
576
UniProt ID:
P38432
International Prot ID:
IPI00006442
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0005730
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008022
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
R
L
R
L
Q
F
D
Y
P
P
P
A
T
P
H
Site 2
T39
L
N
R
C
R
V
V
T
D
L
I
S
L
I
R
Site 3
S43
R
V
V
T
D
L
I
S
L
I
R
Q
R
F
G
Site 4
S53
R
Q
R
F
G
F
S
S
G
A
F
L
G
L
Y
Site 5
S71
G
L
L
P
P
A
E
S
A
R
L
V
R
D
N
Site 6
S94
E
R
G
V
A
E
N
S
V
V
I
S
N
G
D
Site 7
S98
A
E
N
S
V
V
I
S
N
G
D
I
N
L
S
Site 8
S105
S
N
G
D
I
N
L
S
L
R
K
A
K
K
R
Site 9
T122
Q
L
E
E
G
E
E
T
E
P
D
C
K
Y
S
Site 10
Y128
E
T
E
P
D
C
K
Y
S
K
K
H
W
K
S
Site 11
S129
T
E
P
D
C
K
Y
S
K
K
H
W
K
S
R
Site 12
T157
P
K
A
V
T
D
Q
T
V
S
K
K
N
K
R
Site 13
T169
N
K
R
K
N
K
A
T
C
G
T
V
G
D
D
Site 14
S184
N
E
E
A
K
R
K
S
P
K
K
K
E
K
C
Site 15
Y193
K
K
K
E
K
C
E
Y
K
K
K
A
K
N
P
Site 16
S202
K
K
A
K
N
P
K
S
P
K
V
Q
A
V
K
Site 17
S217
D
W
A
N
Q
R
C
S
S
P
K
G
S
A
R
Site 18
S218
W
A
N
Q
R
C
S
S
P
K
G
S
A
R
N
Site 19
S222
R
C
S
S
P
K
G
S
A
R
N
S
L
V
K
Site 20
S226
P
K
G
S
A
R
N
S
L
V
K
A
K
R
K
Site 21
S235
V
K
A
K
R
K
G
S
V
S
V
C
S
K
E
Site 22
S237
A
K
R
K
G
S
V
S
V
C
S
K
E
S
P
Site 23
S240
K
G
S
V
S
V
C
S
K
E
S
P
S
S
S
Site 24
S243
V
S
V
C
S
K
E
S
P
S
S
S
S
E
S
Site 25
S245
V
C
S
K
E
S
P
S
S
S
S
E
S
E
S
Site 26
S246
C
S
K
E
S
P
S
S
S
S
E
S
E
S
C
Site 27
S247
S
K
E
S
P
S
S
S
S
E
S
E
S
C
D
Site 28
S248
K
E
S
P
S
S
S
S
E
S
E
S
C
D
E
Site 29
S250
S
P
S
S
S
S
E
S
E
S
C
D
E
S
I
Site 30
S252
S
S
S
S
E
S
E
S
C
D
E
S
I
S
D
Site 31
S256
E
S
E
S
C
D
E
S
I
S
D
G
P
S
K
Site 32
S258
E
S
C
D
E
S
I
S
D
G
P
S
K
V
T
Site 33
S262
E
S
I
S
D
G
P
S
K
V
T
L
E
A
R
Site 34
S271
V
T
L
E
A
R
N
S
S
E
K
L
P
T
E
Site 35
S272
T
L
E
A
R
N
S
S
E
K
L
P
T
E
L
Site 36
T277
N
S
S
E
K
L
P
T
E
L
S
K
E
E
P
Site 37
S280
E
K
L
P
T
E
L
S
K
E
E
P
S
T
K
Site 38
T286
L
S
K
E
E
P
S
T
K
N
T
T
A
D
K
Site 39
T289
E
E
P
S
T
K
N
T
T
A
D
K
L
A
I
Site 40
T290
E
P
S
T
K
N
T
T
A
D
K
L
A
I
K
Site 41
S301
L
A
I
K
L
G
F
S
L
T
P
S
K
G
K
Site 42
T303
I
K
L
G
F
S
L
T
P
S
K
G
K
T
S
Site 43
S305
L
G
F
S
L
T
P
S
K
G
K
T
S
G
T
Site 44
T309
L
T
P
S
K
G
K
T
S
G
T
T
S
S
S
Site 45
S310
T
P
S
K
G
K
T
S
G
T
T
S
S
S
S
Site 46
T312
S
K
G
K
T
S
G
T
T
S
S
S
S
D
S
Site 47
T313
K
G
K
T
S
G
T
T
S
S
S
S
D
S
S
Site 48
S314
G
K
T
S
G
T
T
S
S
S
S
D
S
S
A
Site 49
S315
K
T
S
G
T
T
S
S
S
S
D
S
S
A
E
Site 50
S316
T
S
G
T
T
S
S
S
S
D
S
S
A
E
S
Site 51
S317
S
G
T
T
S
S
S
S
D
S
S
A
E
S
D
Site 52
S319
T
T
S
S
S
S
D
S
S
A
E
S
D
D
Q
Site 53
S320
T
S
S
S
S
D
S
S
A
E
S
D
D
Q
C
Site 54
S323
S
S
D
S
S
A
E
S
D
D
Q
C
L
M
S
Site 55
S330
S
D
D
Q
C
L
M
S
S
S
T
P
E
C
A
Site 56
S331
D
D
Q
C
L
M
S
S
S
T
P
E
C
A
A
Site 57
S332
D
Q
C
L
M
S
S
S
T
P
E
C
A
A
G
Site 58
S358
G
R
P
G
P
G
L
S
S
Q
T
A
G
A
A
Site 59
S359
R
P
G
P
G
L
S
S
Q
T
A
G
A
A
G
Site 60
S370
G
A
A
G
W
R
R
S
G
S
N
G
G
G
Q
Site 61
S372
A
G
W
R
R
S
G
S
N
G
G
G
Q
A
P
Site 62
S382
G
G
Q
A
P
G
A
S
P
S
V
S
L
P
A
Site 63
S386
P
G
A
S
P
S
V
S
L
P
A
S
L
G
R
Site 64
S390
P
S
V
S
L
P
A
S
L
G
R
G
W
G
R
Site 65
S403
G
R
E
E
N
L
F
S
W
K
G
A
K
G
R
Site 66
S424
R
G
R
G
H
P
V
S
C
V
V
N
R
S
T
Site 67
T431
S
C
V
V
N
R
S
T
D
N
Q
R
Q
Q
Q
Site 68
T456
I
I
Q
N
P
V
E
T
P
K
K
D
Y
S
L
Site 69
S462
E
T
P
K
K
D
Y
S
L
L
P
L
L
A
A
Site 70
S486
F
K
L
L
E
L
T
S
S
Y
S
P
D
V
S
Site 71
S487
K
L
L
E
L
T
S
S
Y
S
P
D
V
S
D
Site 72
S489
L
E
L
T
S
S
Y
S
P
D
V
S
D
Y
K
Site 73
S493
S
S
Y
S
P
D
V
S
D
Y
K
E
G
R
I
Site 74
Y495
Y
S
P
D
V
S
D
Y
K
E
G
R
I
L
S
Site 75
S502
Y
K
E
G
R
I
L
S
H
N
P
E
T
Q
Q
Site 76
Y531
P
G
K
F
D
L
V
Y
H
N
E
N
G
A
E
Site 77
Y542
N
G
A
E
V
V
E
Y
A
V
T
Q
E
S
K
Site 78
S566
D
P
R
L
I
I
E
S
P
S
N
T
S
S
T
Site 79
S568
R
L
I
I
E
S
P
S
N
T
S
S
T
E
P
Site 80
T570
I
I
E
S
P
S
N
T
S
S
T
E
P
A
_
Site 81
S571
I
E
S
P
S
N
T
S
S
T
E
P
A
_
_
Site 82
S572
E
S
P
S
N
T
S
S
T
E
P
A
_
_
_
Site 83
T573
S
P
S
N
T
S
S
T
E
P
A
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation