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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASR
Full Name:
Extracellular calcium-sensing receptor
Alias:
Calcium-sensing receptor; CaSR; FHH; GPRC2A; HHC; HHC1; NSHPT; Parathyroid Cell calcium-sensing receptor; PCAR1; PCaR1; Severe neonatal hyperparathyroidism
Type:
G protein-coupled 7TM receptor
Mass (Da):
120674
Number AA:
1078
UniProt ID:
P41180
International Prot ID:
IPI00012817
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0004435
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0009653
GO:0019722
Phosida
TranscriptoNet
STRING
Kinexus Products
Extracellular calcium sensing receptor pan-specific antibody AB-NN382-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN382-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
L
A
L
T
W
H
T
S
A
Y
G
P
D
Q
R
Site 2
S53
A
K
D
Q
D
L
K
S
R
P
E
S
V
E
C
Site 3
S57
D
L
K
S
R
P
E
S
V
E
C
I
R
Y
N
Site 4
Y63
E
S
V
E
C
I
R
Y
N
F
R
G
F
R
W
Site 5
T100
L
G
Y
R
I
F
D
T
C
N
T
V
S
K
A
Site 6
T103
R
I
F
D
T
C
N
T
V
S
K
A
L
E
A
Site 7
S122
V
A
Q
N
K
I
D
S
L
N
L
D
E
F
C
Site 8
S169
I
P
Q
V
S
Y
A
S
S
S
R
L
L
S
N
Site 9
S170
P
Q
V
S
Y
A
S
S
S
R
L
L
S
N
K
Site 10
S171
Q
V
S
Y
A
S
S
S
R
L
L
S
N
K
N
Site 11
S175
A
S
S
S
R
L
L
S
N
K
N
Q
F
K
S
Site 12
S182
S
N
K
N
Q
F
K
S
F
L
R
T
I
P
N
Site 13
T186
Q
F
K
S
F
L
R
T
I
P
N
D
E
H
Q
Site 14
T195
P
N
D
E
H
Q
A
T
A
M
A
D
I
I
E
Site 15
Y218
T
I
A
A
D
D
D
Y
G
R
P
G
I
E
K
Site 16
S240
R
D
I
C
I
D
F
S
E
L
I
S
Q
Y
S
Site 17
S244
I
D
F
S
E
L
I
S
Q
Y
S
D
E
E
E
Site 18
S247
S
E
L
I
S
Q
Y
S
D
E
E
E
I
Q
H
Site 19
T289
E
I
V
R
R
N
I
T
G
K
I
W
L
A
S
Site 20
S296
T
G
K
I
W
L
A
S
E
A
W
A
S
S
S
Site 21
S303
S
E
A
W
A
S
S
S
L
I
A
M
P
Q
Y
Site 22
S342
K
K
V
H
P
R
K
S
V
H
N
G
F
A
K
Site 23
T372
K
G
P
L
P
V
D
T
F
L
R
G
H
E
E
Site 24
S380
F
L
R
G
H
E
E
S
G
D
R
F
S
N
S
Site 25
S385
E
E
S
G
D
R
F
S
N
S
S
T
A
F
R
Site 26
S387
S
G
D
R
F
S
N
S
S
T
A
F
R
P
L
Site 27
S388
G
D
R
F
S
N
S
S
T
A
F
R
P
L
C
Site 28
T389
D
R
F
S
N
S
S
T
A
F
R
P
L
C
T
Site 29
S402
C
T
G
D
E
N
I
S
S
V
E
T
P
Y
I
Site 30
S403
T
G
D
E
N
I
S
S
V
E
T
P
Y
I
D
Site 31
T406
E
N
I
S
S
V
E
T
P
Y
I
D
Y
T
H
Site 32
Y411
V
E
T
P
Y
I
D
Y
T
H
L
R
I
S
Y
Site 33
T412
E
T
P
Y
I
D
Y
T
H
L
R
I
S
Y
N
Site 34
Y435
A
H
A
L
Q
D
I
Y
T
C
L
P
G
R
G
Site 35
S448
R
G
L
F
T
N
G
S
C
A
D
I
K
K
V
Site 36
S497
S
I
I
N
W
H
L
S
P
E
D
G
S
I
V
Site 37
S502
H
L
S
P
E
D
G
S
I
V
F
K
E
V
G
Site 38
Y510
I
V
F
K
E
V
G
Y
Y
N
V
Y
A
K
K
Site 39
Y511
V
F
K
E
V
G
Y
Y
N
V
Y
A
K
K
G
Site 40
Y514
E
V
G
Y
Y
N
V
Y
A
K
K
G
E
R
L
Site 41
S540
F
S
R
E
V
P
F
S
N
C
S
R
D
C
L
Site 42
Y573
V
E
C
P
D
G
E
Y
S
D
E
T
D
A
S
Site 43
S574
E
C
P
D
G
E
Y
S
D
E
T
D
A
S
A
Site 44
T577
D
G
E
Y
S
D
E
T
D
A
S
A
C
N
K
Site 45
S580
Y
S
D
E
T
D
A
S
A
C
N
K
C
P
D
Site 46
T646
N
T
P
I
V
K
A
T
N
R
E
L
S
Y
L
Site 47
T676
I
G
E
P
Q
D
W
T
C
R
L
R
Q
P
A
Site 48
S749
W
L
Y
T
A
P
P
S
S
Y
R
N
Q
E
L
Site 49
S750
L
Y
T
A
P
P
S
S
Y
R
N
Q
E
L
E
Site 50
T868
L
F
K
P
S
R
N
T
I
E
E
V
R
C
S
Site 51
S875
T
I
E
E
V
R
C
S
T
A
A
H
A
F
K
Site 52
T888
F
K
V
A
A
R
A
T
L
R
R
S
N
V
S
Site 53
S892
A
R
A
T
L
R
R
S
N
V
S
R
K
R
S
Site 54
S895
T
L
R
R
S
N
V
S
R
K
R
S
S
S
L
Site 55
S899
S
N
V
S
R
K
R
S
S
S
L
G
G
S
T
Site 56
S900
N
V
S
R
K
R
S
S
S
L
G
G
S
T
G
Site 57
S901
V
S
R
K
R
S
S
S
L
G
G
S
T
G
S
Site 58
S905
R
S
S
S
L
G
G
S
T
G
S
T
P
S
S
Site 59
T906
S
S
S
L
G
G
S
T
G
S
T
P
S
S
S
Site 60
S908
S
L
G
G
S
T
G
S
T
P
S
S
S
I
S
Site 61
T909
L
G
G
S
T
G
S
T
P
S
S
S
I
S
S
Site 62
S911
G
S
T
G
S
T
P
S
S
S
I
S
S
K
S
Site 63
S912
S
T
G
S
T
P
S
S
S
I
S
S
K
S
N
Site 64
S913
T
G
S
T
P
S
S
S
I
S
S
K
S
N
S
Site 65
S915
S
T
P
S
S
S
I
S
S
K
S
N
S
E
D
Site 66
S916
T
P
S
S
S
I
S
S
K
S
N
S
E
D
P
Site 67
S918
S
S
S
I
S
S
K
S
N
S
E
D
P
F
P
Site 68
S920
S
I
S
S
K
S
N
S
E
D
P
F
P
Q
P
Site 69
T949
E
Q
Q
Q
Q
P
L
T
L
P
Q
Q
Q
R
S
Site 70
S956
T
L
P
Q
Q
Q
R
S
Q
Q
Q
P
R
C
K
Site 71
S976
G
S
G
T
V
T
F
S
L
S
F
D
E
P
Q
Site 72
S978
G
T
V
T
F
S
L
S
F
D
E
P
Q
K
N
Site 73
S992
N
A
M
A
H
R
N
S
T
H
Q
N
S
L
E
Site 74
T993
A
M
A
H
R
N
S
T
H
Q
N
S
L
E
A
Site 75
S1003
N
S
L
E
A
Q
K
S
S
D
T
L
T
R
H
Site 76
T1006
E
A
Q
K
S
S
D
T
L
T
R
H
Q
P
L
Site 77
T1008
Q
K
S
S
D
T
L
T
R
H
Q
P
L
L
P
Site 78
T1026
G
E
T
D
L
D
L
T
V
Q
E
T
G
L
Q
Site 79
S1051
V
E
D
P
E
E
L
S
P
A
L
V
V
S
S
Site 80
T1072
S
G
G
G
S
T
V
T
E
N
V
V
N
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation