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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRKCI
Full Name:
Protein kinase C iota type
Alias:
APKC-lambda,iota; EC 2.7.11.13; HINT1; KPCI; NPKC-iota; PKC lambda; PKC-iota; PKCL
Type:
Adhesion; Motility/polarity/chemotaxis; EC 2.7.11.13; Hydrolase; Protein kinase, Ser/Thr (non-receptor); EC 3.-.-.-; Cell development/differentiation; AGC group; PKC family; Iota subfamily
Mass (Da):
68262
Number AA:
596
UniProt ID:
P41743
International Prot ID:
IPI00016639
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005768
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005543
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0045216
GO:0032869
Phosida
TranscriptoNet
STRING
Kinexus Products
CREB1 (123-135) KinSub - cyclic-AMP response element binding protein-1 (K123-R135, human) peptide; Crebtide protein kinase substrate peptide - Powder PE-01ACP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACP95#PKCISelectide - PKCi (PRKCI) protein kinase substrate peptide - Powder PE-01BIU90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BIU90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
P
T
Q
R
D
S
S
T
M
Site 2
S7
_
M
P
T
Q
R
D
S
S
T
M
S
H
T
V
Site 3
S8
M
P
T
Q
R
D
S
S
T
M
S
H
T
V
A
Site 4
T9
P
T
Q
R
D
S
S
T
M
S
H
T
V
A
G
Site 5
S11
Q
R
D
S
S
T
M
S
H
T
V
A
G
G
G
Site 6
T13
D
S
S
T
M
S
H
T
V
A
G
G
G
S
G
Site 7
S19
H
T
V
A
G
G
G
S
G
D
H
S
H
Q
V
Site 8
S23
G
G
G
S
G
D
H
S
H
Q
V
R
V
K
A
Site 9
Y31
H
Q
V
R
V
K
A
Y
Y
R
G
D
I
M
I
Site 10
Y32
Q
V
R
V
K
A
Y
Y
R
G
D
I
M
I
T
Site 11
S44
M
I
T
H
F
E
P
S
I
S
F
E
G
L
C
Site 12
S46
T
H
F
E
P
S
I
S
F
E
G
L
C
N
E
Site 13
T79
D
E
E
G
D
P
C
T
V
S
S
Q
L
E
L
Site 14
S81
E
G
D
P
C
T
V
S
S
Q
L
E
L
E
E
Site 15
S82
G
D
P
C
T
V
S
S
Q
L
E
L
E
E
A
Site 16
Y93
L
E
E
A
F
R
L
Y
E
L
N
K
D
S
E
Site 17
S123
P
C
P
G
E
D
K
S
I
Y
R
R
G
A
R
Site 18
Y125
P
G
E
D
K
S
I
Y
R
R
G
A
R
R
W
Site 19
Y136
A
R
R
W
R
K
L
Y
C
A
N
G
H
T
F
Site 20
Y169
W
G
L
G
R
Q
G
Y
K
C
I
N
C
K
L
Site 21
T187
K
K
C
H
K
L
V
T
I
E
C
G
R
H
S
Site 22
S194
T
I
E
C
G
R
H
S
L
P
Q
E
P
V
M
Site 23
S206
P
V
M
P
M
D
Q
S
S
M
H
S
D
H
A
Site 24
S210
M
D
Q
S
S
M
H
S
D
H
A
Q
T
V
I
Site 25
T215
M
H
S
D
H
A
Q
T
V
I
P
Y
N
P
S
Site 26
Y219
H
A
Q
T
V
I
P
Y
N
P
S
S
H
E
S
Site 27
S222
T
V
I
P
Y
N
P
S
S
H
E
S
L
D
Q
Site 28
S223
V
I
P
Y
N
P
S
S
H
E
S
L
D
Q
V
Site 29
S226
Y
N
P
S
S
H
E
S
L
D
Q
V
G
E
E
Site 30
T239
E
E
K
E
A
M
N
T
R
E
S
G
K
A
S
Site 31
S242
E
A
M
N
T
R
E
S
G
K
A
S
S
S
L
Site 32
S246
T
R
E
S
G
K
A
S
S
S
L
G
L
Q
D
Site 33
S247
R
E
S
G
K
A
S
S
S
L
G
L
Q
D
F
Site 34
S248
E
S
G
K
A
S
S
S
L
G
L
Q
D
F
D
Site 35
T276
L
L
V
R
L
K
K
T
D
R
I
Y
A
M
K
Site 36
Y280
L
K
K
T
D
R
I
Y
A
M
K
V
V
K
K
Site 37
S310
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
Site 38
S320
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
Site 39
Y358
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
Site 40
S359
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
Site 41
T395
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
Site 42
Y397
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
Site 43
T409
E
G
L
R
P
G
D
T
T
S
T
F
C
G
T
Site 44
T410
G
L
R
P
G
D
T
T
S
T
F
C
G
T
P
Site 45
S411
L
R
P
G
D
T
T
S
T
F
C
G
T
P
N
Site 46
T412
R
P
G
D
T
T
S
T
F
C
G
T
P
N
Y
Site 47
T416
T
T
S
T
F
C
G
T
P
N
Y
I
A
P
E
Site 48
Y430
E
I
L
R
G
E
D
Y
G
F
S
V
D
W
W
Site 49
S459
P
F
D
I
V
G
S
S
D
N
P
D
Q
N
T
Site 50
T466
S
D
N
P
D
Q
N
T
E
D
Y
L
F
Q
V
Site 51
Y469
P
D
Q
N
T
E
D
Y
L
F
Q
V
I
L
E
Site 52
S484
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
Site 53
S495
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
Site 54
S554
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Site 55
T564
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
Site 56
S577
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
Site 57
Y584
S
E
F
E
G
F
E
Y
I
N
P
L
L
M
S
Site 58
S591
Y
I
N
P
L
L
M
S
A
E
E
C
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation