KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TMPO
Full Name:
Lamina-associated polypeptide 2, isoforms beta/gamma
Alias:
Lamina-associated polypeptide 2, isoforms beta/gamma; LAP2; LAP2B; LEM domain containing 4; LEMD4; Splenin; Thymopoietin; Thymopoietin, isoforms beta/gamma; Thymopoietin-related peptide isoforms beta/gamma; TP; TP beta/gamma; TP5; TPRP; TPRP isoforms beta/gamma
Type:
DNA binding protein
Mass (Da):
50670
Number AA:
454
UniProt ID:
P42167
International Prot ID:
IPI00030131
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0016021
GO:0031965
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005521
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0009889
GO:0010468
GO:0010556
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
E
F
L
E
D
P
S
V
L
T
K
D
K
L
Site 2
T12
L
E
D
P
S
V
L
T
K
D
K
L
K
S
E
Site 3
S18
L
T
K
D
K
L
K
S
E
L
V
A
N
N
V
Site 4
Y37
G
E
Q
R
K
D
V
Y
V
Q
L
Y
L
Q
H
Site 5
Y41
K
D
V
Y
V
Q
L
Y
L
Q
H
L
T
A
R
Site 6
T46
Q
L
Y
L
Q
H
L
T
A
R
N
R
P
P
L
Site 7
T57
R
P
P
L
P
A
G
T
N
S
K
G
P
P
D
Site 8
S59
P
L
P
A
G
T
N
S
K
G
P
P
D
F
S
Site 9
S66
S
K
G
P
P
D
F
S
S
D
E
E
R
E
P
Site 10
S67
K
G
P
P
D
F
S
S
D
E
E
R
E
P
T
Site 11
T74
S
D
E
E
R
E
P
T
P
V
L
G
S
G
A
Site 12
S79
E
P
T
P
V
L
G
S
G
A
A
A
A
G
R
Site 13
S87
G
A
A
A
A
G
R
S
R
A
A
V
G
R
K
Site 14
T96
A
A
V
G
R
K
A
T
K
K
T
D
K
P
R
Site 15
T99
G
R
K
A
T
K
K
T
D
K
P
R
Q
E
D
Site 16
T113
D
K
D
D
L
D
V
T
E
L
T
N
E
D
L
Site 17
Y127
L
L
D
Q
L
V
K
Y
G
V
N
P
G
P
I
Site 18
T137
N
P
G
P
I
V
G
T
T
R
K
L
Y
E
K
Site 19
Y142
V
G
T
T
R
K
L
Y
E
K
K
L
L
K
L
Site 20
T154
L
K
L
R
E
Q
G
T
E
S
R
S
S
T
P
Site 21
S156
L
R
E
Q
G
T
E
S
R
S
S
T
P
L
P
Site 22
S158
E
Q
G
T
E
S
R
S
S
T
P
L
P
T
I
Site 23
S159
Q
G
T
E
S
R
S
S
T
P
L
P
T
I
S
Site 24
T160
G
T
E
S
R
S
S
T
P
L
P
T
I
S
S
Site 25
T164
R
S
S
T
P
L
P
T
I
S
S
S
A
E
N
Site 26
S166
S
T
P
L
P
T
I
S
S
S
A
E
N
T
R
Site 27
S167
T
P
L
P
T
I
S
S
S
A
E
N
T
R
Q
Site 28
S168
P
L
P
T
I
S
S
S
A
E
N
T
R
Q
N
Site 29
T172
I
S
S
S
A
E
N
T
R
Q
N
G
S
N
D
Site 30
S177
E
N
T
R
Q
N
G
S
N
D
S
D
R
Y
S
Site 31
S180
R
Q
N
G
S
N
D
S
D
R
Y
S
D
N
E
Site 32
Y183
G
S
N
D
S
D
R
Y
S
D
N
E
E
D
S
Site 33
S184
S
N
D
S
D
R
Y
S
D
N
E
E
D
S
K
Site 34
S190
Y
S
D
N
E
E
D
S
K
I
E
L
K
L
E
Site 35
T208
P
L
K
G
R
A
K
T
P
V
T
L
K
Q
R
Site 36
T211
G
R
A
K
T
P
V
T
L
K
Q
R
R
V
E
Site 37
S222
R
R
V
E
H
N
Q
S
Y
S
Q
A
G
I
T
Site 38
Y223
R
V
E
H
N
Q
S
Y
S
Q
A
G
I
T
E
Site 39
S224
V
E
H
N
Q
S
Y
S
Q
A
G
I
T
E
T
Site 40
T231
S
Q
A
G
I
T
E
T
E
W
T
S
G
S
S
Site 41
T234
G
I
T
E
T
E
W
T
S
G
S
S
K
G
G
Site 42
S235
I
T
E
T
E
W
T
S
G
S
S
K
G
G
P
Site 43
S237
E
T
E
W
T
S
G
S
S
K
G
G
P
L
Q
Site 44
T247
G
G
P
L
Q
A
L
T
R
E
S
T
R
G
S
Site 45
S250
L
Q
A
L
T
R
E
S
T
R
G
S
R
R
T
Site 46
T251
Q
A
L
T
R
E
S
T
R
G
S
R
R
T
P
Site 47
S254
T
R
E
S
T
R
G
S
R
R
T
P
R
K
R
Site 48
T257
S
T
R
G
S
R
R
T
P
R
K
R
V
E
T
Site 49
T264
T
P
R
K
R
V
E
T
S
E
H
F
R
I
D
Site 50
S265
P
R
K
R
V
E
T
S
E
H
F
R
I
D
G
Site 51
S276
R
I
D
G
P
V
I
S
E
S
T
P
I
A
E
Site 52
T279
G
P
V
I
S
E
S
T
P
I
A
E
T
I
M
Site 53
T284
E
S
T
P
I
A
E
T
I
M
A
S
S
N
E
Site 54
S288
I
A
E
T
I
M
A
S
S
N
E
S
L
V
V
Site 55
S289
A
E
T
I
M
A
S
S
N
E
S
L
V
V
N
Site 56
S292
I
M
A
S
S
N
E
S
L
V
V
N
R
V
T
Site 57
T299
S
L
V
V
N
R
V
T
G
N
F
K
H
A
S
Site 58
S306
T
G
N
F
K
H
A
S
P
I
L
P
I
T
E
Site 59
T312
A
S
P
I
L
P
I
T
E
F
S
D
I
P
R
Site 60
S315
I
L
P
I
T
E
F
S
D
I
P
R
R
A
P
Site 61
T327
R
A
P
K
K
P
L
T
R
A
E
V
G
E
K
Site 62
T335
R
A
E
V
G
E
K
T
E
E
R
R
V
E
R
Site 63
Y351
I
L
K
E
M
F
P
Y
E
A
S
T
P
T
G
Site 64
S354
E
M
F
P
Y
E
A
S
T
P
T
G
I
S
A
Site 65
T355
M
F
P
Y
E
A
S
T
P
T
G
I
S
A
S
Site 66
T357
P
Y
E
A
S
T
P
T
G
I
S
A
S
C
R
Site 67
S360
A
S
T
P
T
G
I
S
A
S
C
R
R
P
I
Site 68
S362
T
P
T
G
I
S
A
S
C
R
R
P
I
K
G
Site 69
S378
A
G
R
P
L
E
L
S
D
F
R
M
E
E
S
Site 70
S385
S
D
F
R
M
E
E
S
F
S
S
K
Y
V
P
Site 71
S387
F
R
M
E
E
S
F
S
S
K
Y
V
P
K
Y
Site 72
S388
R
M
E
E
S
F
S
S
K
Y
V
P
K
Y
V
Site 73
Y390
E
E
S
F
S
S
K
Y
V
P
K
Y
V
P
L
Site 74
Y394
S
S
K
Y
V
P
K
Y
V
P
L
A
D
V
K
Site 75
S402
V
P
L
A
D
V
K
S
E
K
T
K
K
G
R
Site 76
S410
E
K
T
K
K
G
R
S
I
P
V
W
I
K
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation