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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STAT1
Full Name:
Signal transducer and activator of transcription 1-alpha/beta
Alias:
ISGF-3; Signal transducer and activator of transcription 1; Signal transducer and activator of transcription 1, 91kDa; STAT91; Transcription factor ISGF-3 components p91/p84
Type:
Transcription factor; Transcription, coactivator/corepressor
Mass (Da):
87335
Number AA:
750
UniProt ID:
P42224
International Prot ID:
IPI00030781
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005062
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007249
GO:0006919
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
Y
E
L
Q
Q
L
D
S
K
F
L
E
Q
V
H
Site 2
Y22
L
E
Q
V
H
Q
L
Y
D
D
S
F
P
M
E
Site 3
Y33
F
P
M
E
I
R
Q
Y
L
A
Q
W
L
E
K
Site 4
S62
I
R
F
H
D
L
L
S
Q
L
D
D
Q
Y
S
Site 5
Y68
L
S
Q
L
D
D
Q
Y
S
R
F
S
L
E
N
Site 6
S69
S
Q
L
D
D
Q
Y
S
R
F
S
L
E
N
N
Site 7
S72
D
D
Q
Y
S
R
F
S
L
E
N
N
F
L
L
Site 8
S86
L
Q
H
N
I
R
K
S
K
R
N
L
Q
D
N
Site 9
Y106
I
Q
M
S
M
I
I
Y
S
C
L
K
E
E
R
Site 10
T133
Q
S
G
N
I
Q
S
T
V
M
L
D
K
Q
K
Site 11
S144
D
K
Q
K
E
L
D
S
K
V
R
N
V
K
D
Site 12
S162
C
I
E
H
E
I
K
S
L
E
D
L
Q
D
E
Site 13
Y170
L
E
D
L
Q
D
E
Y
D
F
K
C
K
T
L
Site 14
T184
L
Q
N
R
E
H
E
T
N
G
V
A
K
S
D
Site 15
S190
E
T
N
G
V
A
K
S
D
Q
K
Q
E
Q
L
Site 16
Y203
Q
L
L
L
K
K
M
Y
L
M
L
D
N
K
R
Site 17
S245
E
W
K
R
R
Q
Q
S
A
C
I
G
G
P
P
Site 18
T264
D
Q
L
Q
N
W
F
T
I
V
A
E
S
L
Q
Site 19
T288
E
E
L
E
Q
K
Y
T
Y
E
H
D
P
I
T
Site 20
T305
K
Q
V
L
W
D
R
T
F
S
L
F
Q
Q
L
Site 21
S316
F
Q
Q
L
I
Q
S
S
F
V
V
E
R
Q
P
Site 22
T327
E
R
Q
P
C
M
P
T
H
P
Q
R
P
L
V
Site 23
T373
K
D
V
N
E
R
N
T
V
K
G
F
R
K
F
Site 24
S395
K
V
M
N
M
E
E
S
T
N
G
S
L
A
A
Site 25
S399
M
E
E
S
T
N
G
S
L
A
A
E
F
R
H
Site 26
S434
T
E
E
L
H
S
L
S
F
E
T
Q
L
C
Q
Site 27
T489
R
N
L
S
F
F
L
T
P
P
C
A
R
W
A
Site 28
S507
E
V
L
S
W
Q
F
S
S
V
T
K
R
G
L
Site 29
S508
V
L
S
W
Q
F
S
S
V
T
K
R
G
L
N
Site 30
T510
S
W
Q
F
S
S
V
T
K
R
G
L
N
V
D
Site 31
S532
K
L
L
G
P
N
A
S
P
D
G
L
I
P
W
Site 32
S583
G
C
I
M
G
F
I
S
K
E
R
E
R
A
L
Site 33
T598
L
K
D
Q
Q
P
G
T
F
L
L
R
F
S
E
Site 34
S604
G
T
F
L
L
R
F
S
E
S
S
R
E
G
A
Site 35
S606
F
L
L
R
F
S
E
S
S
R
E
G
A
I
T
Site 36
S607
L
L
R
F
S
E
S
S
R
E
G
A
I
T
F
Site 37
T613
S
S
R
E
G
A
I
T
F
T
W
V
E
R
S
Site 38
T615
R
E
G
A
I
T
F
T
W
V
E
R
S
Q
N
Site 39
S620
T
F
T
W
V
E
R
S
Q
N
G
G
E
P
D
Site 40
S640
P
Y
T
K
K
E
L
S
A
V
T
F
P
D
I
Site 41
T643
K
K
E
L
S
A
V
T
F
P
D
I
I
R
N
Site 42
Y651
F
P
D
I
I
R
N
Y
K
V
M
A
A
E
N
Site 43
Y666
I
P
E
N
P
L
K
Y
L
Y
P
N
I
D
K
Site 44
Y668
E
N
P
L
K
Y
L
Y
P
N
I
D
K
D
H
Site 45
Y680
K
D
H
A
F
G
K
Y
Y
S
R
P
K
E
A
Site 46
Y681
D
H
A
F
G
K
Y
Y
S
R
P
K
E
A
P
Site 47
T699
E
L
D
G
P
K
G
T
G
Y
I
K
T
E
L
Site 48
Y701
D
G
P
K
G
T
G
Y
I
K
T
E
L
I
S
Site 49
T704
K
G
T
G
Y
I
K
T
E
L
I
S
V
S
E
Site 50
S708
Y
I
K
T
E
L
I
S
V
S
E
V
H
P
S
Site 51
S710
K
T
E
L
I
S
V
S
E
V
H
P
S
R
L
Site 52
S715
S
V
S
E
V
H
P
S
R
L
Q
T
T
D
N
Site 53
T719
V
H
P
S
R
L
Q
T
T
D
N
L
L
P
M
Site 54
S727
T
D
N
L
L
P
M
S
P
E
E
F
D
E
V
Site 55
S735
P
E
E
F
D
E
V
S
R
I
V
G
S
V
E
Site 56
S745
V
G
S
V
E
F
D
S
M
M
N
T
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation