PhosphoNET

           
Protein Info 
   
Short Name:  TTF-1
Full Name:  Homeobox protein Nkx-2.1
Alias:  BCH; Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK2 homeobox 1; NKX2-1; NKX2A; Thyroid nuclear factor 1; TITF1; TTF1
Type:  Transcription factor
Mass (Da):  38596
Number AA:  371
UniProt ID:  P43699
International Prot ID:  IPI00472988
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005654     Uniprot OncoNet
Molecular Function:  GO:0005515  GO:0016563   PhosphoSite+ KinaseNET
Biological Process:  GO:0006350     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S4____MSMSPKHTTPF
Site 2T8MSMSPKHTTPFSVSD
Site 3T9SMSPKHTTPFSVSDI
Site 4S12PKHTTPFSVSDILSP
Site 5S14HTTPFSVSDILSPLE
Site 6S18FSVSDILSPLEESYK
Site 7S23ILSPLEESYKKVGME
Site 8T50QGQAAPPTAAMQQHA
Site 9S81GVPQLSHSAVGGYCN
Site 10Y86SHSAVGGYCNGNLGN
Site 11S95NGNLGNMSELPPYQD
Site 12Y100NMSELPPYQDTMRNS
Site 13T103ELPPYQDTMRNSASG
Site 14S109DTMRNSASGPGWYGA
Site 15S126DPRFPAISRFMGPAS
Site 16S133SRFMGPASGMNMSGM
Site 17S138PASGMNMSGMGGLGS
Site 18S145SGMGGLGSLGDVSKN
Site 19S158KNMAPLPSAPRRKRR
Site 20S169RKRRVLFSQAQVYEL
Site 21Y185RRFKQQKYLSAPERE
Site 22S187FKQQKYLSAPEREHL
Site 23S196PEREHLASMIHLTPT
Site 24S233QQQLQQDSGGGGGGG
Site 25T242GGGGGGGTGCPQQQQ
Site 26S254QQQAQQQSPRRVAVP
Site 27S281APAPGAASLQGHAQQ
Site 28S323HPGHQPGSAGQSPDL
Site 29S327QPGSAGQSPDLAHHA
Site 30S336DLAHHAASPAALQGQ
Site 31S345AALQGQVSSLSHLNS
Site 32S346ALQGQVSSLSHLNSS
Site 33S348QGQVSSLSHLNSSGS
Site 34S352SSLSHLNSSGSDYGT
Site 35S353SLSHLNSSGSDYGTM
Site 36S355SHLNSSGSDYGTMSC
Site 37Y357LNSSGSDYGTMSCST
Site 38T359SSGSDYGTMSCSTLL
Site 39S361GSDYGTMSCSTLLYG
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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