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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHKA1
Full Name:
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
Alias:
Kinase PHKA1; KPB1; PHKA; Phosphorylase B kinase alpha regulatory chain, skeletal muscle isoform; Phosphorylase kinase alpha M; Phosphorylase kinase, alpha 1 (muscle); Skeletal muscle isoform
Type:
Protein-serine kinase, regulatory subunit
Mass (Da):
137312
Number AA:
1223
UniProt ID:
P46020
International Prot ID:
IPI00004247
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0043231
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0004689
PhosphoSite+
KinaseNET
Biological Process:
GO:0005977
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
R
S
R
S
N
S
G
V
R
L
D
Site 2
S7
_
M
R
S
R
S
N
S
G
V
R
L
D
G
Y
Site 3
Y14
S
G
V
R
L
D
G
Y
A
R
L
V
Q
Q
T
Site 4
S36
V
T
G
L
L
P
A
S
Y
D
Q
K
D
A
W
Site 5
Y37
T
G
L
L
P
A
S
Y
D
Q
K
D
A
W
V
Site 6
S80
K
A
Y
E
L
E
Q
S
V
V
K
L
M
R
G
Site 7
S101
R
Q
V
D
K
V
E
S
F
K
Y
S
Q
S
T
Site 8
Y104
D
K
V
E
S
F
K
Y
S
Q
S
T
K
D
S
Site 9
S105
K
V
E
S
F
K
Y
S
Q
S
T
K
D
S
L
Site 10
S107
E
S
F
K
Y
S
Q
S
T
K
D
S
L
H
A
Site 11
S111
Y
S
Q
S
T
K
D
S
L
H
A
K
Y
N
T
Site 12
Y116
K
D
S
L
H
A
K
Y
N
T
K
T
C
A
T
Site 13
T190
I
W
E
R
G
D
K
T
N
Q
G
I
S
E
L
Site 14
S195
D
K
T
N
Q
G
I
S
E
L
N
A
S
S
V
Site 15
S200
G
I
S
E
L
N
A
S
S
V
G
M
A
K
A
Site 16
S201
I
S
E
L
N
A
S
S
V
G
M
A
K
A
A
Site 17
S240
D
E
V
Q
H
C
Q
S
I
L
N
S
L
L
P
Site 18
S244
H
C
Q
S
I
L
N
S
L
L
P
R
A
S
T
Site 19
S250
N
S
L
L
P
R
A
S
T
S
K
E
V
D
A
Site 20
T251
S
L
L
P
R
A
S
T
S
K
E
V
D
A
S
Site 21
Y301
C
R
F
L
R
D
G
Y
K
T
P
K
E
D
P
Site 22
T303
F
L
R
D
G
Y
K
T
P
K
E
D
P
N
R
Site 23
Y312
K
E
D
P
N
R
L
Y
Y
E
P
A
E
L
K
Site 24
Y313
E
D
P
N
R
L
Y
Y
E
P
A
E
L
K
L
Site 25
S374
P
L
L
P
E
L
Y
S
V
P
P
D
R
V
D
Site 26
Y384
P
D
R
V
D
E
E
Y
Q
N
P
H
T
V
D
Site 27
T389
E
E
Y
Q
N
P
H
T
V
D
R
V
P
M
G
Site 28
S431
D
P
L
N
R
R
F
S
T
V
P
K
P
D
V
Site 29
T432
P
L
N
R
R
F
S
T
V
P
K
P
D
V
V
Site 30
T453
A
E
T
E
E
I
K
T
I
L
K
D
K
G
I
Site 31
Y483
A
R
I
L
S
H
I
Y
S
S
L
G
C
N
N
Site 32
S484
R
I
L
S
H
I
Y
S
S
L
G
C
N
N
R
Site 33
Y499
M
K
L
S
G
R
P
Y
R
H
M
G
V
L
G
Site 34
T516
K
L
Y
D
I
R
K
T
I
F
T
F
T
P
Q
Site 35
T519
D
I
R
K
T
I
F
T
F
T
P
Q
F
I
D
Site 36
T521
R
K
T
I
F
T
F
T
P
Q
F
I
D
Q
Q
Site 37
Y531
F
I
D
Q
Q
Q
F
Y
L
A
L
D
N
K
M
Site 38
S548
E
M
L
R
T
D
L
S
Y
L
C
S
R
W
R
Site 39
Y549
M
L
R
T
D
L
S
Y
L
C
S
R
W
R
M
Site 40
T557
L
C
S
R
W
R
M
T
G
Q
P
T
I
T
F
Site 41
T561
W
R
M
T
G
Q
P
T
I
T
F
P
I
S
H
Site 42
T563
M
T
G
Q
P
T
I
T
F
P
I
S
H
S
M
Site 43
S567
P
T
I
T
F
P
I
S
H
S
M
L
D
E
D
Site 44
T576
S
M
L
D
E
D
G
T
S
L
N
S
S
I
L
Site 45
S577
M
L
D
E
D
G
T
S
L
N
S
S
I
L
A
Site 46
S581
D
G
T
S
L
N
S
S
I
L
A
A
L
R
K
Site 47
Y593
L
R
K
M
Q
D
G
Y
F
G
G
A
R
V
Q
Site 48
T601
F
G
G
A
R
V
Q
T
G
K
L
S
E
F
L
Site 49
S605
R
V
Q
T
G
K
L
S
E
F
L
T
T
S
C
Site 50
Y628
P
G
P
E
G
K
L
Y
S
E
D
Y
D
D
N
Site 51
S629
G
P
E
G
K
L
Y
S
E
D
Y
D
D
N
Y
Site 52
Y632
G
K
L
Y
S
E
D
Y
D
D
N
Y
D
Y
L
Site 53
Y636
S
E
D
Y
D
D
N
Y
D
Y
L
E
S
G
N
Site 54
Y638
D
Y
D
D
N
Y
D
Y
L
E
S
G
N
W
M
Site 55
Y648
S
G
N
W
M
N
D
Y
D
S
T
S
H
A
R
Site 56
Y663
C
G
D
E
V
A
R
Y
L
D
H
L
L
A
H
Site 57
S681
H
P
K
L
A
P
T
S
Q
K
G
G
L
D
R
Site 58
S701
Q
T
T
C
D
L
M
S
L
V
T
K
A
K
E
Site 59
Y717
H
V
Q
N
V
H
M
Y
L
P
T
K
L
F
Q
Site 60
S726
P
T
K
L
F
Q
A
S
R
P
S
F
N
L
L
Site 61
S729
L
F
Q
A
S
R
P
S
F
N
L
L
D
S
P
Site 62
S735
P
S
F
N
L
L
D
S
P
H
P
R
Q
E
N
Site 63
S746
R
Q
E
N
Q
V
P
S
V
R
V
E
I
H
L
Site 64
S758
I
H
L
P
R
D
Q
S
G
E
V
D
F
K
A
Site 65
S775
L
Q
L
K
E
T
S
S
L
Q
E
Q
A
D
I
Site 66
Y784
Q
E
Q
A
D
I
L
Y
M
L
Y
T
M
K
G
Site 67
Y799
P
D
W
N
T
E
L
Y
N
E
R
S
A
T
V
Site 68
T805
L
Y
N
E
R
S
A
T
V
R
E
L
L
T
E
Site 69
Y814
R
E
L
L
T
E
L
Y
G
K
V
G
E
I
R
Site 70
Y828
R
H
W
G
L
I
R
Y
I
S
G
I
L
R
K
Site 71
T845
E
A
L
D
E
A
C
T
D
L
L
S
H
Q
K
Site 72
S849
E
A
C
T
D
L
L
S
H
Q
K
H
L
T
V
Site 73
T855
L
S
H
Q
K
H
L
T
V
G
L
P
P
E
P
Site 74
T866
P
P
E
P
R
E
K
T
I
S
A
P
L
P
Y
Site 75
S868
E
P
R
E
K
T
I
S
A
P
L
P
Y
E
A
Site 76
S884
T
Q
L
I
D
E
A
S
E
G
D
M
S
I
S
Site 77
S889
E
A
S
E
G
D
M
S
I
S
I
L
T
Q
E
Site 78
S934
M
A
T
E
L
A
H
S
L
R
C
S
A
E
E
Site 79
S938
L
A
H
S
L
R
C
S
A
E
E
A
T
E
G
Site 80
S950
T
E
G
L
M
N
L
S
P
S
A
M
K
N
L
Site 81
S963
N
L
L
H
H
I
L
S
G
K
E
F
G
V
E
Site 82
S972
K
E
F
G
V
E
R
S
V
R
P
T
D
S
N
Site 83
T976
V
E
R
S
V
R
P
T
D
S
N
V
S
P
A
Site 84
S978
R
S
V
R
P
T
D
S
N
V
S
P
A
I
S
Site 85
S981
R
P
T
D
S
N
V
S
P
A
I
S
I
H
E
Site 86
S985
S
N
V
S
P
A
I
S
I
H
E
I
G
A
V
Site 87
T997
G
A
V
G
A
T
K
T
E
R
T
G
I
M
Q
Site 88
S1007
T
G
I
M
Q
L
K
S
E
I
K
Q
V
E
F
Site 89
S1018
Q
V
E
F
R
R
L
S
I
S
A
E
S
Q
S
Site 90
S1020
E
F
R
R
L
S
I
S
A
E
S
Q
S
P
G
Site 91
S1023
R
L
S
I
S
A
E
S
Q
S
P
G
T
S
M
Site 92
S1025
S
I
S
A
E
S
Q
S
P
G
T
S
M
T
P
Site 93
S1029
E
S
Q
S
P
G
T
S
M
T
P
S
S
G
S
Site 94
T1031
Q
S
P
G
T
S
M
T
P
S
S
G
S
F
P
Site 95
S1033
P
G
T
S
M
T
P
S
S
G
S
F
P
S
A
Site 96
S1034
G
T
S
M
T
P
S
S
G
S
F
P
S
A
Y
Site 97
S1036
S
M
T
P
S
S
G
S
F
P
S
A
Y
D
Q
Site 98
S1039
P
S
S
G
S
F
P
S
A
Y
D
Q
Q
S
S
Site 99
Y1041
S
G
S
F
P
S
A
Y
D
Q
Q
S
S
K
D
Site 100
S1045
P
S
A
Y
D
Q
Q
S
S
K
D
S
R
Q
G
Site 101
S1049
D
Q
Q
S
S
K
D
S
R
Q
G
Q
W
Q
R
Site 102
S1095
E
G
F
V
L
P
S
S
T
T
R
E
M
T
P
Site 103
T1096
G
F
V
L
P
S
S
T
T
R
E
M
T
P
G
Site 104
T1101
S
S
T
T
R
E
M
T
P
G
E
I
K
F
S
Site 105
S1113
K
F
S
V
H
V
E
S
V
L
N
R
V
P
Q
Site 106
T1168
L
F
L
Q
E
Q
K
T
L
G
A
D
D
T
M
Site 107
T1174
K
T
L
G
A
D
D
T
M
L
A
K
D
P
A
Site 108
Y1189
S
G
I
C
T
L
L
Y
D
S
A
P
S
G
R
Site 109
T1199
A
P
S
G
R
F
G
T
M
T
Y
L
S
K
A
Site 110
T1201
S
G
R
F
G
T
M
T
Y
L
S
K
A
A
A
Site 111
Y1202
G
R
F
G
T
M
T
Y
L
S
K
A
A
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation